Search Results - "Smith, Bryan Ronain"

Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation by Smith, Bryan Ronain, Kempen, Paul, Bouley, Donna, Xu, Alexander, Liu, Zhuang, Melosh, Nicholas, Dai, Hongjie, Sinclair, Robert, Gambhir, Sanjiv Sam

“…Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles…”
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Nanotherapeutic Shots through the Heart of Plaque by Kanthi, Yogendra, de la Zerda, Adam, Smith, Bryan Ronain

“…The past several decades have brought significant advances in the application of clinical and preclinical nanoparticulate drugs in the field of cancer, but…”
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Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis by Flores, Alyssa M., Hosseini-Nassab, Niloufar, Jarr, Kai-Uwe, Ye, Jianqin, Zhu, Xingjun, Wirka, Robert, Koh, Ai Leen, Tsantilas, Pavlos, Wang, Ying, Nanda, Vivek, Kojima, Yoko, Zeng, Yitian, Lotfi, Mozhgan, Sinclair, Robert, Weissman, Irving L., Ingelsson, Erik, Smith, Bryan Ronain, Leeper, Nicholas J.

“…Atherosclerosis is the process that underlies heart attack and stroke. A characteristic feature of the atherosclerotic plaque is the accumulation of apoptotic…”
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Particle tracking microrheology of cancer cells in living subjects by Wu, Pei-Hsun, Gambhir, Sanjiv Sam, Hale, Christopher M., Chen, Wei-Chiang, Wirtz, Denis, Smith, Bryan Ronain

“…[Display omitted] Cumulative evidence shows that microenvironmental conditions play a significant role in the regulation of cell functions, and how cells…”
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Real-Time Intravital Imaging of RGD−Quantum Dot Binding to Luminal Endothelium in Mouse Tumor Neovasculature by Smith, Bryan Ronain, Cheng, Zhen, De, Abhijit, Koh, Ai Leen, Sinclair, Robert, Gambhir, Sanjiv Sam

“…Nanoscale materials have increasingly become subject to intense investigation for use in cancer diagnosis and therapy. However, there is a fundamental dearth…”
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Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis by Bamezai, Sharika, Zhang, Yapei, Kumari, Manisha, Lotfi, Mozhgan, Alsaigh, Tom, Luo, Lingfeng, Kumar, Gayatri Suresh, Wang, Fudi, Ye, Jianqin, Puri, Madhu, Manchanda, Romila, Paluri, Sesha, Adkar, Shaunak S., Kojima, Yoko, Ingelsson, Alice, Bell, Caitlin F., Lopez, Nicolas G., Fu, Changhao, Choi, Ryan B., Miller, Zach, Barrios, Leo, Walsh, Susan, Ahmad, Ferhaan, Maegdefessel, Lars, Smith, Bryan Ronain, Leeper, Nicholas J.

“…Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal of cells by…”
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High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model by Smith, Bryan Ronain, Zavaleta, Cristina, Rosenberg, Jarrett, Tong, Ricky, Ramunas, John, Liu, Zhuang, Dai, Hongjie, Gambhir, Sanjiv Sam

“… [Display omitted] ► Quantitatively de-convoluted carbon nanotube targeting to tumors in live mice. ► Microscale visualization of targeting from injection to…”
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Nano-immunoimaging by Wang, Ping, Kim, Taeho, Harada, Masako, Contag, Christopher, Huang, Xuefei, Smith, Bryan Ronain

“…Immunoimaging is a rapidly growing field stoked in large part by the intriguing triumphs of immunotherapy. On the heels of immunotherapy's successes, there…”
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Dynamic Visualization of RGD-Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy by Smith, Bryan Ronain, Cheng, Zhen, De, Abhijit, Rosenberg, Jarrett, Gambhir, Sanjiv Sam

“…The behavior of targeted quantum dots (Qdots) across three different tumor models using intravital microscopy with submicrometer resolution is described. As in…”
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Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing by Rostami, Neda, Gomari, Mohammad Mahmoudi, Choupani, Edris, Abkhiz, Shadi, Fadaie, Mahmood, Eslami, Seyed Sadegh, Mahmoudi, Zahra, Zhang, Yapei, Puri, Madhu, Monfared, Fatemeh Nafe, Demireva, Elena, Uversky, Vladimir N., Smith, Bryan Ronain, Bencherif, Sidi A.

“…The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct…”
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Nanomaterials for In Vivo Imaging by Smith, Bryan Ronain, Gambhir, Sanjiv Sam

“…In vivo imaging, which enables us to peer deeply within living subjects, is producing tremendous opportunities both for clinical diagnostics and as a research…”
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Nanotherapeutics for cardiovascular disease by Smith, Bryan Ronain

“…Nanotherapies are emerging rapidly as options to treat cardiovascular disease. However, insufficient and heterogeneous delivery remain critical issues. Novel…”
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High-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease by Leeper, Nicholas J., MD, Park, Seung-min, PhD, Smith, Bryan Ronain, PhD

“…Central Illustration Schematic of HDL Nanoparticles Used for PET Imaging High-density lipoprotein (HDL) nanoparticles were synthesized containing the positron…”
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Mechanical deformation and death of circulating tumor cells in the bloodstream by Qiu, Yunxiu, Gao, Tong, Smith, Bryan Ronain

“…The circulation of tumor cells through the bloodstream is a significant step in tumor metastasis. To better understand the metastatic process, circulating…”
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Quantitative Drug Release Monitoring in Tumors of Living Subjects by Magnetic Particle Imaging Nanocomposite by Zhu, Xingjun, Li, Jianfeng, Peng, Peng, Hosseini Nassab, Niloufar, Smith, Bryan Ronain

“…In vivo drug release monitoring provides accurate and reliable information to guide drug dosing. Image-based strategies for in vivo monitoring are advantageous…”
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Nanomedicines for cardiovascular disease by Smith, Bryan Ronain, Edelman, Elazer R

“…The leading cause of death in the world, cardiovascular disease (CVD), remains a formidable condition for researchers, clinicians and patients alike. CVD…”
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Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy by Delfi, Masoud, Sartorius, Rossella, Ashrafizadeh, Milad, Sharifi, Esmaeel, Zhang, Yapei, De Berardinis, Piergiuseppe, Zarrabi, Ali, Varma, Rajender S., Tay, Franklin R., Smith, Bryan Ronain, Makvandi, Pooyan

“…•Self-assembled peptide and protein nanostructures deliver therapeutics to cancer cells.•Stimuli-responsive nanoarchitectures of peptide/protein respond to…”
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Nanoparticle-Based Therapies in Hypertension by Story, Darren, Aminoroaya, Alireza, Skelton, Zak, Kumari, Manisha, Zhang, Yapei, Smith, Bryan Ronain

“…Nearly 1.4 billion people worldwide suffer from arterial hypertension, a significant risk factor for cardiovascular disease which is now the leading cause of…”
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Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery by Smith, Bryan Ronain, Ghosn, Eliver Eid Bou, Rallapalli, Harikrishna, Prescher, Jennifer A., Larson, Timothy, Herzenberg, Leonore A., Gambhir, Sanjiv Sam

“…In cancer imaging, nanoparticle biodistribution is typically visualized in living subjects using ‘bulk’ imaging modalities such as magnetic resonance imaging,…”
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Gum polysaccharide/nanometal hybrid biocomposites in cancer diagnosis and therapy by Makvandi, Pooyan, Baghbantaraghdari, Zahra, Zhou, Wenxian, Zhang, Yapei, Manchanda, Romila, Agarwal, Tarun, Wu, Aimin, Maiti, Tapas Kumar, Varma, Rajender S., Smith, Bryan Ronain

“…Biopolymers are of prime importance among which gum polysaccharides hold an eminent standing owing to their high availability and non-toxic nature. Gum…”
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