Search Results - "Smith, B. P"

Challenges and Opportunities in Rare Disease Drug Development by Smith, BP

“…Each month, Clinical Pharmacology & Therapeutics focuses on a particular theme. Twice a year, the associate editors, editors, and staff get together to discuss…”
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A systematic review of randomized controlled trials for the prevention of bronchopulmonary dysplasia in infants by Beam, K S, Aliaga, S, Ahlfeld, S K, Cohen-Wolkowiez, M, Smith, P B, Laughon, M M

“…Objective: Bronchopulmonary dysplasia (BPD) is the most common cause of pulmonary morbidity in premature infants and is associated with life-long morbidities…”
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Impediments to Clinical Research in the United States by Kramer, J M, Smith, P B, Califf, R M

“…Clinical trials are essential to the evaluation of promising scientific discoveries, but they are becoming unsustainably burdensome, threatening to deprive…”
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Safety and Pharmacokinetics of Multiple-Dose Anidulafungin in Infants and Neonates by Cohen‐Wolkowiez, M, Benjamin, DK, Piper, L, Cheifetz, IM, Moran, C, Liu, P, Aram, J, Kashuba, ADM, Capparelli, E, Walsh, TJ, Hope, WW, Smith, PB

“…Candida infections are common and often fatal in infants and neonates. Anidulafungin has excellent activity against Candida species, but the pharmacokinetics…”
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Safety and Pharmacokinetics of Repeat-Dose Micafungin in Young Infants by Benjamin, D K, Smith, P B, Arrieta, A, Castro, L, Sánchez, P J, Kaufman, D, Arnold, L J, Kovanda, L L, Sawamoto, T, Buell, D N, Hope, W W, Walsh, T J

“…Given the risk of central nervous system infection, relatively high weight‐based echinocandin dosages may be required for the successful treatment of invasive…”
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Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood by Schell, W. A., Benton, J. L., Smith, P. B., Poore, M., Rouse, J. L., Boles, D. J., Johnson, M. D., Alexander, B. D., Pamula, V. K., Eckhardt, A. E., Pollack, M. G., Benjamin, D. K., Perfect, J. R., Mitchell, T. G.

“…Species of Candida frequently cause life-threatening infections in neonates, transplant and intensive care unit (ICU) patients, and others with compromised…”
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Novel approaches to address challenges in global drug development by Smith, BP, Huang, S-M

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Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome by Tolia, V N, Murthy, K, Bennett, M M, Miller, E S, Benjamin, D K, Smith, P B, Clark, R H

“…Objective: Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns. However, comparative effects on…”
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Arid Coastal Carbonates and the Phanerozoic Record of Carbonate Chemistry by Smith, B. P., Cantine, M. D., Bergmann, K. D., Ramos, E. J., Martindale, R. C., Kerans, C.

“…Ocean chemistry and carbonate sedimentation link Earth's climate, carbon cycle, and marine pH. The carbonate system in seawater is complex and there are large…”
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Movember Is Mustache Month by Paine, MF, Smith, BP

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Geochemical modelling of the evolution and fate of metal pollutants arising from an abandoned gold mine tailings facility in Johannesburg by CAMDEN-SMITH, B. P. C, TUTU, H

“…Analytical techniques were combined with geochemical modelling to study the release mechanisms of pollutants from an abandoned gold mining tailings storage…”
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Motor cortical functional geometry in cerebral palsy and its relationship to disability by Kesar, T.M, Sawaki, L, Burdette, J.H, Cabrera, M.N, Kolaski, K, Smith, B.P, O’Shea, T.M, Koman, L.A, Wittenberg, G.F

“…Highlights ► In cerebral palsy patients, for the first time, we demonstrate hand maps lateral to the expected location, and replicate the finding of…”
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Fluconazole pharmacokinetics and safety in premature infants by Turner, K, Manzoni, P, Benjamin, D K, Cohen-Wolkowiez, M, Smith, P B, Laughon, M M

“…Invasive candidiasis (IC) in the premature infant population is a common infection that results in substantial morbidity and mortality. For these patients,…”
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Ignorance is not bliss: Statistical power is not probability of trial success by Zierhut, ML, Bycott, P, Gibbs, MA, Smith, BP, Vicini, P

“…The purpose of this commentary is to place probability of trial success, or assurance, in the context of decision making in drug development, and to illustrate…”
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Confidence interval criteria for assessment of dose proportionality by SMITH, Brian P, VANDENHENDE, Francois R, DESANTE, Karl A, FARID, Nagy A, WELCH, Pamela A, CALLAGHAN, John T, FORGUE, S. Thomas

“…The aim of this work was a pragmatic, statistically sound and clinically relevant approach to dose-proportionality analyses that is compatible with common…”
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Pharmacokinetics, Safety, and Tolerability of Atomoxetine and Effect of CYP2D610/10 Genotype in Healthy Japanese Men by Matsui, A., Azuma, J., Witcher, J. W., Long, A. J., Sauer, J.-M., Smith, B. P., DeSante, K. A., Read, H. A., Takahashi, M., Nakano, M.

“…Atomoxetine is a cytochrome P4502D6 (CYP2D6) substrate. The reduced-activity CYP2D6*10 allele is particularly prevalent in the Japanese population and may…”
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Cough in Pediatric Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy or Angiotensin Receptor Blocker Therapy in Randomized Controlled Trials by Baker‐Smith, C M, Benjamin, D K, Califf, R M, Murphy, M D, Li, J S, Smith, P B

“…The incidence of cough in children receiving antihypertension therapy with angiotensin‐converting enzyme inhibitors (ACEis) or angiotensin receptor blockers…”
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Racial Differences in Blood Pressure Response to Angiotensin-Converting Enzyme Inhibitors in Children: A Meta-Analysis by Li, JS, Baker‐Smith, CM, Smith, PB, Hasselblad, V, Murphy, MD, Califf, RM, Benjamin, DK

“…Angiotensin‐converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.1 ACE inhibitors alter the balance between the…”
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Tracing energy inputs into the seafloor using carbonate sediments by Smith, B P, Edie, S M, Fischer, W W

“…Carbonate rocks provide unique and valuable sedimentary archives for secular changes in Earth's physical, chemical, and biological processes. However, reading…”
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Cartilage injuries: a review of 31,516 knee arthroscopies by Curl, W W, Krome, J, Gordon, E S, Rushing, J, Smith, B P, Poehling, G G

“…Although articular cartilage injuries of the knee are common, injured cartilage has a limited ability to heal. Recent data suggest that articular cartilage…”
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