Search Results - "Smith, Andrew J.H"

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment by Brown, Jill M, Green, Joanne, das Neves, Ricardo Pires, Wallace, Helen A.C, Smith, Andrew J.H, Hughes, Jim, Gray, Nicki, Taylor, Steve, Wood, William G, Higgs, Douglas R, Iborra, Francisco J, Buckle, Veronica J

“…Genes on different chromosomes can be spatially associated in the nucleus in several transcriptional and regulatory situations; however, the functional…”
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Tcf15 Primes Pluripotent Cells for Differentiation by Davies, Owen R., Lin, Chia-Yi, Radzisheuskaya, Aliaksandra, Zhou, Xinzhi, Taube, Jessica, Blin, Guillaume, Waterhouse, Anna, Smith, Andrew J.H., Lowell, Sally

“…The events that prime pluripotent cells for differentiation are not well understood. Inhibitor of DNA binding/differentiation (Id) proteins, which are…”
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Hes1 Desynchronizes Differentiation of Pluripotent Cells by Modulating STAT3 Activity by Zhou, Xinzhi, Smith, Andrew J.H., Waterhouse, Anna, Blin, Guillaume, Malaguti, Mattias, Lin, Chia‐Yi, Osorno, Rodrigo, Chambers, Ian, Lowell, Sally

“…Robust development of the early embryo may benefit from mechanisms that ensure that not all pluripotent cells differentiate at exactly the same time: such…”
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Genetic dissection of the α-globin super-enhancer in vivo by Hay, Deborah, Hughes, Jim R, Babbs, Christian, Davies, James O J, Graham, Bryony J, Hanssen, Lars L P, Kassouf, Mira T, Oudelaar, A Marieke, Sharpe, Jacqueline A, Suciu, Maria C, Telenius, Jelena, Williams, Ruth, Rode, Christina, Li, Pik-Shan, Pennacchio, Len A, Sloane-Stanley, Jacqueline A, Ayyub, Helena, Butler, Sue, Sauka-Spengler, Tatjana, Gibbons, Richard J, Smith, Andrew J H, Wood, William G, Higgs, Douglas R

“…Douglas Higgs and colleagues functionally test the α-globin super-enhancer in mice by genetically deleting its constituent enhancers. They find that the…”
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Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles by Stewart, A. Francis, Testa, Giuseppe, Zhang, Youming, Vintersten, Kristina, Benes, Vladimir, Pijnappel, W.W.M. Pim, Chambers, Ian, Smith, Andrew J.H, Smith, Austin G

“…The mouse is the leading vertebrate model because its genome can be altered by both random transgenesis and homologous recombination with targeting constructs…”
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Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance by DELIBEGOVIC, Mirela, ARMSTRONG, Christopher G, DOBBIE, Lorraine, WATT, Peter W, SMITH, Andrew J. H, COHEN, Patricia T. W

“…Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development…”
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p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ by Guillermet-Guibert, Julie, Bjorklof, Katja, Salpekar, Ashreena, Gonella, Cristiano, Ramadani, Faruk, Bilancio, Antonio, Meek, Stephen, Smith, Andrew J.H, Okkenhaug, Klaus, Vanhaesebroeck, Bart

“…The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and…”
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Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence by Nowell, Craig S, Bredenkamp, Nicholas, Tetélin, Stéphanie, Jin, Xin, Tischner, Christin, Vaidya, Harsh, Sheridan, Julie M, Stenhouse, Frances Hogg, Heussen, Raphaela, Smith, Andrew J H, Blackburn, C Clare

“…The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC)…”
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A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination by Smith, Andrew J.H, De Sousa, Michelle A, Kwabi-Addo, Bernard, Heppell-Parton, Amanda, Impey, Helen, Rabbitts, Pamela

“…We have developed a strategy for chromosome engineering in embryonic stem (ES) cells that relies on sequential gene targeting and Cre-loxP site-specific…”
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Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice by Okkenhaug, Klaus, Bilancio, Antonio, Farjot, Géraldine, Priddle, Helen, Sancho, Sara, Peskett, Emma, Pearce, Wayne, Meek, Stephen E., Salpekar, Ashreena, Waterfield, Michael D., Andrew J. H. Smith, Vanhaesebroeck, Bart

“…Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that generate second messenger signals downstream of tyrosine…”
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Neurofascins Are Required to Establish Axonal Domains for Saltatory Conduction by Sherman, Diane L., Tait, Steven, Melrose, Shona, Johnson, Richard, Zonta, Barbara, Court, Felipe A., Macklin, Wendy B., Meek, Stephen, Smith, Andrew J.H., Cottrell, David F., Brophy, Peter J.

“…Voltage-gated sodium channels are concentrated in myelinated nerves at the nodes of Ranvier flanked by paranodal axoglial junctions. Establishment of these…”
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Genomically humanized mice: technologies and promises by Devoy, Anny, Bunton-Stasyshyn, Rosie K. A., Tybulewicz, Victor L. J., Smith, Andrew J. H., Fisher, Elizabeth M. C.

“…This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and…”
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Polycomb eviction as a new distant enhancer function by Vernimmen, Douglas, Lynch, Magnus D, De Gobbi, Marco, Garrick, David, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Smith, Andrew J H, Higgs, Douglas R

“…Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly understood…”
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Essential role for proteinase-activated receptor-2 in arthritis by Ferrell, William R, Lockhart, John C, Kelso, Elizabeth B, Dunning, Lynette, Plevin, Robin, Meek, Stephen E, Smith, Andrew J H, Hunter, Gary D, McLean, John S, McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi

“…Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in…”
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Essential role for proteinase-activated receptor-2 in arthritis by Ferrell, William R., Lockhart, John C., Kelso, Elizabeth B., Dunning, Lynette, Plevin, Robin, Meek, Stephen E., Smith, Andrew J.H., Hunter, Gary D., McLean, John S., McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi

“…Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in…”
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues by Garrick, David, Sharpe, Jackie A, Arkell, Ruth, Dobbie, Lorraine, Smith, Andrew J H, Wood, William G, Higgs, Douglas R, Gibbons, Richard J

“…ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations…”
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Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation by Musa, Hanny, Meek, Stephen, Gautel, Mathias, Peddie, Dianna, Smith, Andrew J.H, Peckham, Michelle

“…Titin, a multifunctional protein that stretches from the Z-disk to the M-band in heart and skeletal muscle, contains a kinase domain, phosphorylation sites and…”
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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors by SOUSLOVA, Veronika, CESARE, Paolo, NEBENIUS-DOSTHULZEN, Dantela, SMITH, Andrew J. H, KIDD, Emma J, WOOD, John N, YANNING DING, AKOPLAN, Armen N, STANFA, Loulse, SUZUKI, Rie, CARPENTER, Katherine, DICKENSON, Anthony, BOYCE, Susan, HILL, Ray

“…ATP activates damage-sensing neurons (nociceptors) and can evoke a sensation of pain. The ATP receptor P2X3 is selectively expressed by nociceptors and is one…”
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Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation by Wang, Yu, Tatham, Michael H, Schmidt-Heck, Wolfgang, Swann, Carolyn, Singh-Dolt, Karamjit, Meseguer-Ripolles, Jose, Lucendo-Villarin, Baltasar, Kunath, Tilo, Rudd, Timothy R, Smith, Andrew J H, Hengstler, Jan G, Godoy, Patricio, Hay, Ronald T, Hay, David C

“…During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor…”
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Metalloprotease‐disintegrin ADAM8: Expression analysis and targeted deletion in mice by Kelly, Kristine, Hutchinson, Gillian, Nebenius‐Oosthuizen, Daniela, Smith, Andrew J.H., Bartsch, Jörg W., Horiuchi, Keisuke, Rittger, Andrea, Manova, Katia, Docherty, Andy J.P., Blobel, Carl P.

“…ADAM8 (a disintegrin and metalloprotease 8, also referred to as MS2/CD156a) is a membrane‐anchored metalloprotease that was first identified in a macrophage…”
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