Search Results - "Smith, Andrew J O"

Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts by Cooksley, Grace, Nam, Mi‐Hyun, Nahomi, Rooban B., Rankenberg, Johanna, Smith, Andrew J. O., Wormstone, Yvette M., Wormstone, I. Michael, Nagaraj, Ram H.

“…Posterior capsule opacification (PCO) is a common complication after cataract surgery. Residual lens epithelial cells (LECs) on the anterior lens capsule,…”
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Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient by Cobb, Andrew M., Larrieu, Delphine, Warren, Derek T., Liu, Yiwen, Srivastava, Sonal, Smith, Andrew J. O., Bowater, Richard P., Jackson, Stephen P., Shanahan, Catherine M.

“…Summary The nuclear lamina is essential for the proper structure and organization of the nucleus. Deregulation of A‐type lamins can compromise genomic…”
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Sulforaphane can protect lens cells against oxidative stress: implications for cataract prevention by Liu, Hanruo, Smith, Andrew J O, Lott, Martin C, Bao, Yongping, Bowater, Richard P, Reddan, John R, Wormstone, Ian Michael

“…Protecting the lens against oxidative stress is of great importance in delaying the onset of cataract. Isothiocyanates, such as sulforaphane (SFN), are…”
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Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells by Liu, Peng, Wang, Wei, Zhou, Zhigang, Smith, Andrew J O, Bowater, Richard P, Wormstone, Ian Michael, Chen, Yuqiong, Bao, Yongping

“…Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites…”
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Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens by Wang, Lixin, Eldred, Julie A., Sidaway, Peter, Sanderson, Julie, Smith, Andrew J.O., Bowater, Richard P., Reddan, John R., Wormstone, I. Michael

“…► Oxidative insult increases sigma 1 receptor expression and ER stress in human lens cells. ► Stimulation of the sigma 1 receptor provides significant…”
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Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention by Smith, Andrew J O, Eldred, Julie A, Wormstone, I Michael

“…Posterior capsule opacification (PCO) is a common complication of cataract surgery. In addition to improved surgical methods and IOL designs, it is likely…”
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AGEs in human lens capsule promote the TGFβ2‐mediated EMT of lens epithelial cells: implications for age‐associated fibrosis by Raghavan, Cibin T., Smuda, Mareen, Smith, Andrew J. O., Howell, Scott, Smith, Dawn G., Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A., Wormstone, Ian Michael, Nagaraj, Ram H.

“…Summary Proteins in basement membrane (BM) are long‐lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is…”
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Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3 by Nam, Mi-Hyun, Smith, Andrew J O, Pantcheva, Mina B, Park, Ko Uoon, Brzezinski, Joseph A, Galligan, James J, Fritz, Kristofer, Wormstone, I Michael, Nagaraj, Ram H

“…Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens…”
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Sulforaphane promotes ER stress, autophagy, and cell death: implications for cataract surgery by Liu, Hanruo, Smith, Andrew JO, Ball, Simon SR, Bao, Yongping, Bowater, Richard P, Wang, Ningli, Michael Wormstone, I.

“…Posterior capsule opacification (PCO) commonly develops following cataract surgery and is a wound-healing response that can ultimately lead to secondary visual…”
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PARP-1 inhibition influences the oxidative stress response of the human lens by Smith, Andrew J O, Ball, Simon S R, Bowater, Richard P, Wormstone, I Michael

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is best characterised for its involvement in DNA repair. PARP-1 activity is also linked to cell fate, confounding its…”
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Comet assay measures of DNA damage as biomarkers of irinotecan response in colorectal cancer in vitro and in vivo by Wood, Joanna P., Smith, Andrew J. O., Bowman, Karen J., Thomas, Anne L., Jones, George D. D.

“…The use of irinotecan to treat metastatic colorectal cancer (CRC) is limited by unpredictable response and variable toxicity; however, no reliable clinical…”
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Structure and Kinetics of Leaching for the Formation of Skeletal (Raney) Cobalt Catalysts by Smith, Andrew J, Garciano, Leonito O, Tran, Tam, Wainwright, Mark S

“…The reaction front during leaching of cobalt−aluminum alloys to form skeletal cobalt is sharp and well-defined. In situ milling of a sample by dual-beam…”
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Effect of Chromate Addition on the Structure and Kinetics of Leaching for the Formation of Promoted Skeletal (Raney) Cobalt Catalysts by Smith, Andrew J, Garciano, Leonito O, Tran, Tam

“…The internal porous structure of a chromia-promoted skeletal cobalt catalyst was directly and clearly imaged for the first time. The structure was made finer…”
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AGEs in human lens capsule promote the TGF[beta]2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis by Raghavan, Cibin T, Smuda, Mareen, Smith, Andrew J O, Howell, Scott, Smith, Dawn G, Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus A, Wormstone, Ian Michael, Nagaraj, Ram H

“…Summary Proteins in basement membrane (BM) are long-lived and accumulate chemical modifications during aging; advanced glycation endproduct (AGE) formation is…”
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