Search Results - "Smith, Andrew A."
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Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality?
Published in Developmental cell (23-06-2014)“…Internal organs are asymmetrically positioned inside the body. Embryonic motile cilia play an essential role in this process by generating a directional fluid…”
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The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs
Published in PLoS biology (25-09-2023)“…Translational control is critical for cell fate transitions during development, lineage specification, and tumorigenesis. Here, we show that the transcription…”
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Programming of adiposity in childhood and adolescence: associations with birth weight and cord blood adipokines
Published in The journal of clinical endocrinology and metabolism (01-02-2017)“…Context:Exposure to maternal adiposity during pregnancy is associated with higher offspring birthweight and greater adiposity through childhood and adult life…”
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Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth
Published in Journal of investigative dermatology (01-08-2016)“…Wnt signaling is required for the development of the hair follicle, and for inciting the growth (anagen) phase of the hair cycle. Most strategies to enhance…”
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DUX4 expression in cancer induces a metastable early embryonic totipotent program
Published in Cell reports (Cambridge) (26-09-2023)“…The transcription factor DUX4 regulates a portion of the zygotic gene activation (ZGA) program in the early embryo. Many cancers express DUX4 but it is unknown…”
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Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles
Published in BMC medicine (13-11-2019)“…It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live…”
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Live-Birth Rate Associated With Repeat In Vitro Fertilization Treatment Cycles
Published in JAMA : the journal of the American Medical Association (22-12-2015)“…IMPORTANCE: The likelihood of achieving a live birth with repeat in vitro fertilization (IVF) is unclear, yet treatment is commonly limited to 3 or 4 embryo…”
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External validation and calibration of IVFpredict: a national prospective cohort study of 130,960 in vitro fertilisation cycles
Published in PloS one (08-04-2015)“…Accurately predicting the probability of a live birth after in vitro fertilisation (IVF) is important for patients, healthcare providers and policy makers. Two…”
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Synthesis and Characterization of Heterometallic {Cr7M} Wheels
Published in Angewandte Chemie International Edition (03-01-2003)“…A new set of wheels: Substituting a chromium ion in [Cr8F8(O2CCMe3)16] with one of a number of alternative transition metals has yielded an unprecedented…”
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Synthetic and Structural Studies of Cobalt-Pivalate Complexes
Published in Chemistry : a European journal (17-10-2003)“…The synthesis and characterisation of a range of cobalt pivalate cage complexes are reported. The cages include: a dinuclear CoII complex; an oxo‐centred CoIII…”
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The capacity of neural crest-derived stem cells for ocular repair
Published in Birth defects research. Part C. Embryo today (01-09-2014)“…Whether it is due to a particular epigenetic signature, or some other component of an embryonic differentiation program, accumulating evidence indicates that…”
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Magnetic Anisotropy of the Antiferromagnetic Ring [Cr8F8Piv16]
Published in Chemistry : a European journal (04-01-2002)“…A new tetragonal (P4212) crystalline form of [Cr8F8Piv16] (HPiv=pivalic acid, trimethyl acetic acid) is reported. The ring‐shaped molecules, which are aligned…”
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13
Model Selection of the Effect of Binary Exposures over the Life Course
Published in Epidemiology (Cambridge, Mass.) (01-09-2015)“…Epidemiologists are often interested in examining the effect on a later-life outcome of an exposure measured repeatedly over the life course. When different…”
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14
Augmenting endogenous Wnt signaling improves skin wound healing
Published in PloS one (18-10-2013)“…Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing…”
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Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: the Avon Longitudinal Study of Parents and Children
Published in Journal of child psychology and psychiatry (01-08-2023)“…Background Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal…”
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Wnt signaling and injury repair
Published in Cold Spring Harbor perspectives in biology (01-08-2012)“…Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell…”
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Dietary patterns obtained through principal components analysis: the effect of input variable quantification
Published in British journal of nutrition (28-05-2013)“…Principal components analysis (PCA) is a popular method for deriving dietary patterns. A number of decisions must be made throughout the analytic process,…”
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Dietary patterns in UK adolescents obtained from a dual-source FFQ and their associations with socio-economic position, nutrient intake and modes of eating
Published in Public health nutrition (01-07-2014)“…To derive dietary patterns using principal components analysis from separate FFQ completed by mothers and their teenagers and to assess associations with…”
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The mental health effects of pet death during childhood: is it better to have loved and lost than never to have loved at all?
Published in European child & adolescent psychiatry (01-10-2021)“…Pet ownership is common. Growing evidence suggests children form deep emotional attachments to their pets. Yet, little is known about children’s emotional…”
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Human DUX4 and porcine DUXC activate similar early embryonic programs in pig muscle cells: implications for preclinical models of FSHD
Published in Human molecular genetics (18-05-2023)“…Abstract Human DUX4 and its mouse ortholog Dux are normally expressed in the early embryo—the 4-cell or 2-cell cleavage stage embryo, respectively—and activate…”
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