Search Results - "Smith, Alexandra G."

Autophagy, cancer stem cells and drug resistance by Smith, Alexandra G, Macleod, Kay F

“…Autophagy is a cellular survival mechanism that is induced by cancer therapy, among other stresses, and frequently contributes to cancer cell survival during…”
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Incurable but treatable: Understanding, uncertainty and impact in chronic blood cancers-A qualitative study from the UK's Haematological Malignancy Research Network by Howell, Debra A, McCaughan, Dorothy, Smith, Alexandra G, Patmore, Russell, Roman, Eve

“…Most blood cancers are incurable and typically follow unpredictable remitting-relapsing pathways associated with varying need for treatment, which may be…”
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Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors by Owen, Jeremy G., Charlop-Powers, Zachary, Smith, Alexandra G., Ternei, Melinda A., Calle, Paula Y., Reddy, Boojala Vijay B., Montiel, Daniel, Brady, Sean F.

“…In molecular evolutionary analyses, short DNA sequences are used to infer phylogenetic relationships among species. Here we apply this principle to the study…”
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Myeloma: Patient accounts of their pathways to diagnosis by Howell, Debra A, Hart, Ruth I, Smith, Alexandra G, Macleod, Una, Patmore, Russell, Cook, Gordon, Roman, Eve

“…Pathways to myeloma diagnosis can be prolonged, and are often preceded by multiple GP consultations and emergency presentation. This is the first qualitative…”
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Palliative care specialists' perceptions concerning referral of haematology patients to their services: findings from a qualitative study by McCaughan, Dorothy, Roman, Eve, Smith, Alexandra G, Garry, Anne C, Johnson, Miriam J, Patmore, Russell D, Howard, Martin R, Howell, Debra A

“…Haematological malignancies (leukaemias, lymphomas and myeloma) are complex cancers that are relatively common, affect all ages and have divergent outcomes…”
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Destined to die in hospital? Systematic review and meta-analysis of place of death in haematological malignancy by Howell, Debra A, Roman, Eve, Cox, Helen, Smith, Alexandra G, Patmore, Russell, Garry, Anne C, Howard, Martin R

“…Haematological malignancies are a common, heterogeneous and complex group of diseases that are often associated with poor outcomes despite intensive treatment…”
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Hodgkin lymphoma detection and survival: findings from the Haematological Malignancy Research Network by Lamb, Maxine Je, Roman, Eve, Howell, Debra A, Kane, Eleanor, Bagguley, Timothy, Burton, Cathy, Patmore, Russell, Smith, Alexandra G

“…Hodgkin lymphoma is usually detected in primary care with early signs and symptoms, and is highly treatable with standardised chemotherapy. However, late…”
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Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report by Lacy, Stuart E., Barrans, Sharon L., Beer, Philip A., Painter, Daniel, Smith, Alexandra G., Roman, Eve, Cooke, Susanna L., Ruiz, Camilo, Glover, Paul, Van Hoppe, Suzan J.L., Webster, Nichola, Campbell, Peter J., Tooze, Reuben M., Patmore, Russell, Burton, Cathy, Crouch, Simon, Hodson, Daniel J.

“…Based on the profile of genetic alterations occurring in tumor samples from selected diffuse large B-cell lymphoma (DLBCL) patients, 2 recent whole-exome…”
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Feasibility trial of the school‐based STRONG intervention to promote resilience among newcomer youth by Crooks, Claire V., Hoover, Sharon, Smith, Alexandra C. G.

“…There are thousands of refugee students in Canadian schools and many struggle with distress and trauma symptoms. Even those not demonstrating overt distress…”
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Epidemiology of lymphomas by Roman, Eve, Smith, Alexandra G

“…Roman E & Smith A G
(2011) Histopathology 58, 4–14
Epidemiology of lymphomas Epidemiological reports on lymphomas often begin, and sometimes end, by stating…”
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BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver by Springer, Maya Z., Poole, Logan P., Drake, Lauren E., Bock-Hughes, Althea, Boland, Michelle L, Smith, Alexandra G., Hart, John, Chourasia, Aparajita H., Liu, Ivan, Bozek, Grazyna, Macleod, Kay F

“…Mitophagy formed the basis of the original description of autophagy by Christian de Duve when he demonstrated that GCG (glucagon) induced…”
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An Intron Splice Acceptor Polymorphism in hMSH2 and Risk of Leukemia after Treatment with Chemotherapeutic Alkylating Agents by WORRILLOW, Lisa J, TRAVIS, Lois B, ROMAN, Eve, MORGAN, Gareth J, ALLAN, James M, SMITH, Alexandra G, ROLLINSON, Sara, SMITH, Andrew J, WILD, Christopher P, HOLOWATY, Eric J, KOHLER, Betsy A, WIKLUND, Tom, PUKKALA, Eero

“…Purpose: We sought to determine whether the −6 exon 13 T>C polymorphism in the DNA mismatch repair gene hMSH2 modulates susceptibility to acute myeloid…”
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Patient perspectives of ‘Watch and Wait’ for chronic haematological cancers: Findings from a qualitative study by McCaughan, Dorothy, Roman, Eve, Sheridan, Rebecca, Hewison, Ann, Smith, Alexandra G., Patmore, Russell, Howell, Debra A.

“…Chronic blood cancers are incurable, and characterised by unpredictable, remitting-relapsing pathways. Management often involves periods of observation prior…”
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Perspectives of bereaved relatives of patients with haematological malignancies concerning preferred place of care and death: A qualitative study by McCaughan, Dorothy, Roman, Eve, Smith, Alexandra G, Garry, Anne C, Johnson, Miriam J, Patmore, Russell D, Howard, Martin R, Howell, Debra A

“…Background: People with haematological malignancies have different end-of-life care patterns from those with other cancers and are more likely to die in…”
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Disease-related factors affecting timely lymphoma diagnosis: a qualitative study exploring patient experiences by Howell, Debra A, Hart, Ruth I, Smith, Alexandra G, Macleod, Una, Patmore, Russell, Roman, Eve

“…Expediting cancer diagnosis is widely perceived as one way to improve patient outcomes. Evidence indicates that lymphoma diagnosis is often delayed, yet…”
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Determinants of hospital death in haematological cancers: findings from a qualitative study by McCaughan, Dorothy, Roman, Eve, Smith, Alexandra G, Garry, Anne, Johnson, Miriam, Patmore, Russell, Howard, Martin, Howell, Debra A

“…Current UK health policy promotes enabling people to die in a place they choose, which for most is home. Despite this, patients with haematological…”
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Time-to-diagnosis and symptoms of myeloma, lymphomas and leukaemias: a report from the Haematological Malignancy Research Network by Howell, Debra A, Smith, Alexandra G, Jack, Andrew, Patmore, Russell, Macleod, Una, Mironska, Emma, Roman, Eve

“…Prior to diagnosis, patients with haematological cancers often have multiple primary care consultations, resulting in diagnostic delay. They are less likely to…”
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Risk factors and time to symptomatic presentation in leukaemia, lymphoma and myeloma by Howell, Debra A, Warburton, Fiona, Ramirez, Amanda-Jane, Roman, Eve, Smith, Alexandra G, Forbes, Lindsay J L

“…Background: UK policy aims to improve cancer outcomes by promoting early diagnosis, which for many haematological malignancies is particularly challenging as…”
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Medical History, Lifestyle, Family History, and Occupational Risk Factors for Follicular Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project by Linet, Martha S., Vajdic, Claire M., Morton, Lindsay M., de Roos, Anneclaire J., Skibola, Christine F., Boffetta, Paolo, Cerhan, James R., Flowers, Christopher R., de Sanjosé, Silvia, Monnereau, Alain, Cocco, Pierluigi, Kelly, Jennifer L., Smith, Alexandra G., Weisenburger, Dennis D., Clarke, Christina A., Blair, Aaron, Bernstein, Leslie, Zheng, Tongzhang, Miligi, Lucia, Clavel, Jacqueline, Benavente, Yolanda, Chiu, Brian C. H.

“…Background Follicular lymphoma (FL) has been linked with cigarette smoking and, inconsistently, with other risk factors. Methods We assessed associations of…”
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Haematology nurses' perspectives of their patients' places of care and death: A UK qualitative interview study by McCaughan, Dorothy, Roman, Eve, Smith, Alexandra G., Garry, Anne C., Johnson, Miriam J., Patmore, Russell D., Howard, Martin R., Howell, Debra A.

“…Patients with haematological malignancies are more likely to die in hospital, and less likely to access palliative care than people with other cancers, though…”
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