Search Results - "Smith, Alexander W."

Reinstatement of nicotine seeking is mediated by glutamatergic plasticity by Gipson, Cassandra D., Reissner, Kathryn J., Kupchik, Yonatan M., Smith, Alexander C. W., Stankeviciute, Neringa, Hensley-Simon, Megan E., Kalivas, Peter W.

“…Nicotine abuse and addiction is a major health liability. Nicotine, an active alkaloid in tobacco, is self-administered by animals and produces cellular…”
Get full text

Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions by Smith, Alexander C. W., Jonkman, Sietse, Difeliceantonio, Alexandra G., O’Connor, Richard M., Ghoshal, Soham, Romano, Michael F., Everitt, Barry J., Kenny, Paul J.

“…Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is…”
Get full text

Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics by Langford-Smith, Alexander W. W., Hasan, Ahmad, Weston, Ria, Edwards, Nicola, Jones, Alan M., Boulton, Andrew J. M., Bowling, Frank L., Rashid, S. Tawqeer, Wilkinson, Fiona L., Alexander, M. Yvonne

“…Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes, leading to poor vascular endothelial repair, which contributes to…”
Get full text

Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking by Lepack, Ashley E, Werner, Craig T, Stewart, Andrew F, Fulton, Sasha L, Zhong, Ping, Farrelly, Lorna A, Smith, Alexander C W, Ramakrishnan, Aarthi, Lyu, Yang, Bastle, Ryan M, Martin, Jennifer A, Mitra, Swarup, O'Connor, Richard M, Wang, Zi-Jun, Molina, Henrik, Turecki, Gustavo, Shen, Li, Yan, Zhen, Calipari, Erin S, Dietz, David M, Kenny, Paul J, Maze, Ian

“…Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries,…”
Get full text

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases by Smith, Alexander C W, Kupchik, Yonatan M, Scofield, Michael D, Gipson, Cassandra D, Wiggins, Armina, Thomas, Charles A, Kalivas, Peter W

“…Synaptic remodeling in the brain is dependent on the extracellular matrix remodeling mediated by zinc-dependent matrix metalloproteinases (MMPs). Using a…”
Get full text

Endothelial Progenitor Cells: New Targets for Therapeutics for Inflammatory Conditions With High Cardiovascular Risk by Edwards, Nicola, Langford-Smith, Alexander W W, Wilkinson, Fiona L, Alexander, M Yvonne

“…Over the past decade, we have witnessed an exponential growth of interest into the role of endothelial progenitor cells (EPCs) in cardiovascular disease. While…”
Get full text

Enzymatic Characterization of Dihydrolipoamide Dehydrogenase from Streptococcus pneumoniae Harboring Its Own Substrate by Håkansson, Anders P., Smith, Alexander W.

“…This study describes the enzymatic characterization of dihydrolipoamide dehydrogenase (DLDH) from Streptococcus pneumoniae and is the first characterization of…”
Get full text

Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking by Buchta, William C., Moutal, Aubin, Hines, Bethany, Garcia-Keller, Constanza, Smith, Alexander C. W., Kalivas, Peter, Khanna, Rajesh, Riegel, Arthur C.

“…Cocaine addiction remains a major health concern with limited effective treatment options. A better understanding of mechanisms underlying relapse may help…”
Get full text

Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy by Holley, Rebecca J, Ellison, Stuart M, Fil, Daniel, O'Leary, Claire, McDermott, John, Senthivel, Nishanthi, Langford-Smith, Alexander W W, Wilkinson, Fiona L, D'Souza, Zelpha, Parker, Helen, Liao, Aiyin, Rowlston, Samuel, Gleitz, Hélène F E, Kan, Shih-Hsin, Dickson, Patricia I, Bigger, Brian W

“…There are currently no treatments for mucopolysaccharidosis IIIB. Holley et al. develop a lentiviral-driven stem cell gene therapy in mice that corrects…”
Get full text

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation by Briggs, David C., Langford-Smith, Alexander W.W., Birchenough, Holly L., Jowitt, Thomas A., Kielty, Cay M., Enghild, Jan J., Baldock, Clair, Milner, Caroline M., Day, Anthony J.

“…Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two…”
Get full text

Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration by Calipari, Erin S, Godino, Arthur, Salery, Marine, Damez-Werno, Diane M, Cahill, Michael E, Werner, Craig T, Gancarz, Amy M, Peck, Emily G, Jlayer, Zahra, Rabkin, Jacqui, Landry, Joseph A, Smith, Alexander C W, Defilippi, Paola, Kenny, Paul J, Hurd, Yasmin L, Neve, Rachael L, Dietz, David M, Nestler, Eric J

“…Addictive behaviors, including relapse, are thought to depend in part on long-lasting drug-induced adaptations in dendritic spine signaling and morphology in…”
Get full text

κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats by Nealey, Kathryn A., Smith, Alexander W., Davis, Seth M., Smith, Daniel G., Walker, Brendan M.

“…Previously, it was shown that ethanol-dependent animals display increased sensitivity to the general opioid receptor antagonist nalmefene compared to…”
Get full text

Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking by Roberts‐Wolfe, Douglas J., Heinsbroek, Jasper A., Spencer, Sade M., Bobadilla, Ana Clara, Smith, Alexander C.W., Gipson, Cassandra D., Kalivas, Peter W.

“…Repeated exposure to drug‐associated cues without reward (extinction) leads to refraining from drug seeking in rodents. We determined if refraining is…”
Get full text

Simulation Improves Internal Medicine Resident Confidence With Defibrillation, Cardioversion, and Transcutaneous Pacemaker Use by Smith, Alexander W, Elliott, John O, Gable, Brad D

“…Introduction While many graduate medical education programs require residents to be certified in advanced cardiac life support, this does not cover all aspects…”
Get full text

Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems by Smith, Alexander W., Nealey, Kathryn A., Wright, John W., Walker, Brendan M.

“…► Intermittent ethanol vapor exposure resulted in escalated operant self-administration for ethanol during acute withdrawal in dependent animals. ► Chronic…”
Get full text

High quality, high throughput, and low-cost simultaneous video recording of 60 animals in operant chambers using PiRATeMC by Ramborger, Jarryd, Kalra, Sumay, Mosquera, Joseph, Smith, Alexander C.W., George, Olivier

“…The development of Raspberry Pi-based recording devices for video analyses of drug self-administration studies has been shown to be promising in terms of…”
Get full text

QRISK3 improves detection of cardiovascular disease risk in patients with systemic lupus erythematosus by Edwards, Nicola, Langford-Smith, Alexander W W, Parker, Benjamin J, Bruce, Ian N, Reynolds, John A, Alexander, M Yvonne, McCarthy, Eoghan M, Wilkinson, Fiona L

“…Objective10-year cardiovascular disease (CVD) risk scores are calculated using algorithms, including Framingham (worldwide) and QRISK2 (UK). Recently, an…”
Get full text

The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction by Smith, Alexander C.W, Scofield, Michael D, Kalivas, Peter W

“…Abstract Synaptic plasticity has long been known to involve three key elements of neuropil, the presynapse, the postsynapse and adjacent glia. Here we review…”
Get full text

The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression by Smith, Alexander L. W., Harmer, Catherine J., Cowen, Philip J., Murphy, Susannah E.

“…Clinical depression is a common, debilitating and heterogenous disorder. Existing treatments for depression are inadequate for a significant minority of…”
Get full text

A Glitch in the Matrix: Aberrant Extracellular Matrix Proteolysis Contributes to Alcohol Seeking by Smith, Alexander C.W

Get full text