Search Results - "Smith, Adrian L."

Host Selection of Microbiota via Differential Adhesion by McLoughlin, Kirstie, Schluter, Jonas, Rakoff-Nahoum, Seth, Smith, Adrian L., Foster, Kevin R.

“…The host epithelium is the critical interface with microbial communities, but the mechanisms by which the host regulates these communities are poorly…”
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Repeat and single dose administration of gadodiamide to rats to investigate concentration and location of gadolinium and the cell ultrastructure by Davies, Julie, Marino, Michael, Smith, Adrian P. L., Crowder, Janell M., Larsen, Michael, Lowery, Lisa, Castle, Jason, Hibberd, Mark G., Evans, Paul M.

“…Gadolinium based contrast agents (GBCA) are used to image patients using magnetic resonance (MR) imaging. In recent years, there has been controversy around…”
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Reconstructing the history of helminth prevalence in the UK by Ryan, Hannah, Flammer, Patrik G, Nicholson, Rebecca, Loe, Louise, Reeves, Ben, Allison, Enid, Guy, Christopher, Doriga, Inés Lopez, Waldron, Tony, Walker, Don, Kirchhelle, Claas, Larson, Greger, Smith, Adrian L

“…Intestinal helminth parasites (worms) have afflicted humans throughout history and their eggs are readily detected in archaeological deposits including at…”
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The influence of biotic and abiotic factors on the bacterial microbiome of gentoo penguins (Pygoscelis papua) in their natural environment by Kaczvinsky, Chloe, Levy, Hila, Preston, Stephen, Youngflesh, Casey, Clucas, Gemma, Lynch, Heather J., Hart, Tom, Smith, Adrian L.

“…The microbiome is a key factor in the health, well-being, and success of vertebrates, contributing to the adaptive capacity of the host. However, the impact of…”
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Visualizing the Neutrophil Response to Sterile Tissue Injury in Mouse Dermis Reveals a Three-Phase Cascade of Events by Ng, Lai Guan, Qin, Jim S., Roediger, Ben, Wang, Yilin, Jain, Rohit, Cavanagh, Lois L., Smith, Adrian L., Jones, Cheryl A., de Veer, Michael, Grimbaldeston, Michele A., Meeusen, Els N., Weninger, Wolfgang

“…Neutrophil granulocytes traffic into sites of organ injury in which they may not only participate in tissue repair and pathogen clearance but may also…”
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Can good broiler flock welfare prevent colonization by Campylobacter? by Rawson, Thomas, Colles, Frances M., Smith, Adrian L., Dawkins, Marian Stamp, Bonsall, Michael B.

“…Using data on rearing and welfare metrics of multiple commercial broiler flocks, we investigate how welfare measures such as hock burn, mortality, and…”
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A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors by Peroval, Marylene Y, Boyd, Amy C, Young, John R, Smith, Adrian L

“…Toll-like Receptors (TLR) are phylogenetically conserved transmembrane proteins responsible for detection of pathogens and activation of immune responses in…”
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High resolution parallel sequencing reveals multistrain Campylobacter in broiler chicken flocks testing ‘negative’ by conventional culture methods: implications for control of Campylobacter infection by Colles, Frances M., Karasova, Daniela, Crhanova, Magdalena, Preston, Stephen G., Smith, Adrian L., Dawkins, Marian S., Rychlik, Ivan, Gebhardt-Henrich, Sabine G.

“…Contaminated chicken meat is a major source of human Campylobacteriosis and rates of infection remain high, despite efforts to limit the colonisation of…”
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Repertoire analysis of γδ T cells in the chicken enables functional annotation of the genomic region revealing highly variable pan-tissue TCR gamma V gene usage as well as identifying public and private repertoires by Dixon, Robert, Preston, Stephen G, Dascalu, Stefan, Flammer, Patrik G, Fiddaman, Steven R, McLoughlin, Kirstie, Boyd, Amy, Volf, Jiri, Rychlik, Ivan, Bonsall, Michael B, Kaspers, Bernd, Smith, Adrian L

“…Despite increasing interest in γδ T cells and their non-classical behaviour, most studies focus on animals with low numbers of circulating γδ T cells, such as…”
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Immunisation of chickens with inactivated and/or infectious H9N2 avian influenza virus leads to differential immune B-cell repertoire development by Dascalu, Stefan, Sealy, Joshua E., Sadeyen, Jean-Remy, Flammer, Patrik G., Fiddaman, Steven, Preston, Stephen G., Dixon, Robert J., Bonsall, Michael B., Smith, Adrian L., Iqbal, Munir

“…Avian influenza viruses (AIVs) are a major economic burden to the poultry industry and pose serious zoonotic risks, with human infections being reported every…”
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Transient and Prolonged Response of Chicken Cecum Mucosa to Colonization with Different Gut Microbiota by Volf, Jiri, Polansky, Ondrej, Varmuzova, Karolina, Gerzova, Lenka, Sekelova, Zuzana, Faldynova, Marcela, Babak, Vladimir, Medvecky, Matej, Smith, Adrian L, Kaspers, Bernd, Velge, Philippe, Rychlik, Ivan

“…In this study we determined protein and gene expression in the caeca of newly hatched chickens inoculated with cecal contents sourced from hens of different…”
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Interferon-Inducible Protein 16 (IFI16) Has a Broad-Spectrum Binding Ability Against ssDNA Targets: An Evolutionary Hypothesis for Antiretroviral Checkpoint by Hurst, Tara Patricia, Aswad, Amr, Karamitros, Timokratis, Katzourakis, Aris, Smith, Adrian L, Magiorkinis, Gkikas

“…Human endogenous retroviruses (HERVs) are under genomic and epigenetic control but can be expressed in normal tissues, producing RNA transcripts some of which…”
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The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion by Introini, Viola, Marin-Menendez, Alejandro, Nettesheim, Guilherme, Lin, Yen-Chun, Kariuki, Silvia N., Smith, Adrian L., Jean, Letitia, Brewin, John N., Rees, David C., Cicuta, Pietro, Rayner, Julian C., Penman, Bridget S.

“…Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with…”
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Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK) by Smith, Adrian L, Andrews, Kristin L, Beckmann, Holger, Bellon, Steven F, Beltran, Pedro J, Booker, Shon, Chen, Hao, Chung, Young-Ah, D’Angelo, Noel D, Dao, Jennifer, Dellamaggiore, Kenneth R, Jaeckel, Peter, Kendall, Richard, Labitzke, Katja, Long, Alexander M, Materna-Reichelt, Silvia, Mitchell, Petia, Norman, Mark H, Powers, David, Rose, Mark, Shaffer, Paul L, Wu, Michelle M, Lipford, J. Russell

“…The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent,…”
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Correction to: Repertoire analysis of γδ T cells in the chicken enables functional annotation of the genomic region revealing highly variable pan-tissue TCR gamma V gene usage as well as identifying public and private repertoires by Dixon, Robert, Preston, Stephen G., Dascalu, Stefan, Flammer, Patrik G., Fiddaman, Steven R., McLoughlin, Kirstie, Boyd, Amy, Volf, Jiri, Rychlik, Ivan, Bonsall, Michael B., Kaspers, Bernd, Smith, Adrian L.

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Challenges in the successful control of the avian coccidia by Shirley, Martin W, Smith, Adrian L, Blake, Damer P

“…Abstract Eimeria species infect livestock in a host-specific manner and are the cause of the disease, coccidiosis. Control of Eimeria species is essential and…”
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Epidemiological insights from a large-scale investigation of intestinal helminths in Medieval Europe by Flammer, Patrik G, Ryan, Hannah, Preston, Stephen G, Warren, Sylvia, Prichystalová, Renáta, Weiss, Rainer, Palmowski, Valerie, Boschert, Sonja, Fellgiebel, Katarina, Jasch-Boley, Isabelle, Kairies, Madita-Sophie, Rümmele, Ernst, Rieger, Dirk, Schmid, Beate, Reeves, Ben, Nicholson, Rebecca, Loe, Louise, Guy, Christopher, Waldron, Tony, Machácek, Jirí, Wahl, Joachim, Pollard, Mark, Larson, Greger, Smith, Adrian L, Chai, jong-Yil, Siles-Lucas, Mar

“…Helminth infections are among the World Health Organization's top neglected diseases with significant impact in many Less Economically Developed Countries…”
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Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird by Levy, Hila, Fiddaman, Steven R, Vianna, Juliana A, Noll, Daly, Clucas, Gemma V, Sidhu, Jasmine K H, Polito, Michael J, Bost, Charles A, Phillips, Richard A, Crofts, Sarah, Miller, Gary D, Pistorius, Pierre, Bonnadonna, Francesco, Le Bohec, Céline, Barbosa, Andrés, Trathan, Phil, Raya Rey, Andrea, Frantz, Laurent A F, Hart, Tom, Smith, Adrian L

“…Abstract Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction…”
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TLR15 is unique to avian and reptilian lineages and recognizes a yeast-derived agonist by Boyd, Amy C, Peroval, Marylene Y, Hammond, John A, Prickett, Michael D, Young, John R, Smith, Adrian L

“…The TLRs represent a family of pattern recognition receptors critical in the induction of vertebrate immune responses. Between 10 and 13 different TLR genes…”
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The influences of microbial colonisation and germ-free status on the chicken TCRβ repertoire by Dascalu, Stefan, Preston, Stephen G, Dixon, Robert J, Flammer, Patrik G, Fiddaman, Steven, Boyd, Amy, Sealy, Joshua E, Sadeyen, Jean-Remy, Kaspers, Bernd, Velge, Philippe, Iqbal, Munir, Bonsall, Michael B, Smith, Adrian L

“…Microbial colonisation is paramount to the normal development of the immune system, particularly at mucosal sites. However, the relationships between the…”
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