Search Results - "Smith, A.J.P"

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes by Pang, D.X, Smith, A.J.P, Humphries, S.E

“…Abstract Background and aims Common non-coding variations within the TCF7L2 locus have a strong influence on type 2 diabetes (T2D) susceptibility through…”
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Functional analysis of the chromosome 21q22 (gene desert) variant associated with CHD risk by Beaney, K.E, Folkersen, L, Drenos, F, Smith, A.J.P, Erikkson, P, Humphries, S.E

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Demonstration of the presence of the “deleted” miR-122 gene in HepG2 cells by Hamad, I.A.Y, Fei, Y, Kalea, A.Z, Yin, D, Smith, A.J.P, Palmen, J, Humphries, S.E, Talmud, P.J, Walker, A.P

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Functional analysis of the BCAR1-CFDP1-TMEM170A locus associated with carotid intima-media thickness and plaque by Boardman-Pretty, F.A, Smith, A.J.P, Frankel, P, Evans, I.M, Zachary, I.C, Hamsten, A, Gertow, K, Humphries, S.E

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Interleukin-1 region meta-analysis with osteoarthritis phenotypes by Moxley, G, Meulenbelt, I, Chapman, K, van Diujn, C.M, Eline Slagboom, P, Neale, M.C, Smith, A.J.P, Carr, A.J, Loughlin, J

“…Summary Objective Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes. The results…”
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FUNCTIONAL ANALYSIS OF REGULATORY LPL SNPS by Smith, A.J.P, Drenos, F, Palmen, J, Putt, W, Talmud, P.J, Humphries, S.E

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Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis by Kerkhof, H.J.M, Doherty, M, Arden, N.K, Abramson, S.B, Attur, M, Bos, S.D, Cooper, C, Dennison, E.M, Doherty, S.A, Evangelou, E, Hart, D.J, Hofman, A, Javaid, K, Kerna, I, Kisand, K, Kloppenburg, M, Krasnokutsky, S, Maciewicz, R.A, Meulenbelt, I, Muir, K.R, Rivadeneira, F, Samuels, J, Sezgin, M, Slagboom, E, Smith, A.J.P, Spector, T.D, Tamm, A, Uitterlinden, A.G, Wheeler, M, Zhai, G, Zhang, W, van Meurs, J.B.J, Valdes, A.M

“…Summary Objective To clarify the role of common genetic variation in the Interleukin-1β ( IL1B ) and Interleukin-1R antagonist ( IL1RN ) genes on risk of knee…”
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INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects by Smith, A.J.P, Cooper, J.A, Li, L.K, Humphries, S.E

“…A common polymorphism, rs7566605, 10 kb upstream of the insulin-induced gene 2 transcription start site has been associated with obesity in Caucasian and…”
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Effects of genetic variation on chromatin structure and the transcriptional machinery: analysis of the IL6 gene locus by Smith, A J P, Zheng, D, Palmen, J, Pang, D X, Woo, P, Humphries, S E

“…The presence of functional regulatory polymorphism at the interleukin 6 ( IL6 ) locus is uncertain, with many conflicting in vitro findings. To examine the in…”
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Identification of a novel regulatory region in the interleukin-6 gene promoter by Samuel, J.M., Kelberman, D., Smith, A.J.P., Humphries, S.E., Woo, P.

“…Interleukin-6 (IL6) is an important pleiotropic cytokine that is regulated at the transcriptional level. To date, most work on its regulation has focused on a…”
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Haplotypes of the low-density lipoprotein receptor-related protein 5 ( LRP5) gene: Are they a risk factor in osteoarthritis? by Smith, A.J.P., Gidley, J., Sandy, J.R., Perry, M.J., Elson, C.J., Kirwan, J.R., Spector, T.D., Doherty, M., Bidwell, J.L., Mansell, J.P.

“…Several genome-wide scans have revealed an osteoarthritis (OA)-susceptibility locus on chromosome 11q in close proximity to the low-density lipoprotein…”
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WO7-OR-5 FUNCTIONAL IL6 POLYMORPHISM IS ASSOCIATED WITH IL-6 SERUM LEVELS BUT NOT CVD by Smith, A.J.P., Cooper, J., Palmen, J., Samuel, J., Thompson, S., Woo, P., Humphries, S.E.

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