Search Results - "Smit, Vincent T. H. B M"

Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients by de Kruijf, Esther M., van Nes, Johanna G. H., van de Velde, Cornelis J. H., Putter, Hein, Smit, Vincent T. H. B. M., Liefers, Gerrit Jan, Kuppen, Peter J. K., Tollenaar, Rob A. E. M., Mesker, Wilma E.

“…Stroma tissue surrounding cancer cells plays an important role in tumor development and behavior. In colorectal cancer, it has been found that the amount of…”
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Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry by Vermij, Lisa, Jobsen, Jan J., León-Castillo, Alicia, Brinkhuis, Mariel, Roothaan, Suzan, Powell, Melanie E., de Boer, Stephanie M., Khaw, Pearly, Mileshkin, Linda R., Fyles, Anthony, Leary, Alexandra, Genestie, Catherine, Jürgenliemk-Schulz, Ina M., Crosbie, Emma J., Mackay, Helen J., Nijman, Hans. W., Nout, Remi A., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Horeweg, Nanda, Bosse, Tjalling

“…Background Risk-assessment of endometrial cancer (EC) is based on clinicopathological factors and molecular subgroup. It is unclear whether adding hormone…”
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Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor–positive early breast cancer patients by van Nes, Johanna G. H., de Kruijf, Esther M., Putter, Hein, Faratian, Dana, Munro, Alison, Campbell, Fiona, Smit, Vincent T. H. B. M., Liefers, Gerrit-Jan, Kuppen, Peter J. K., van de Velde, Cornelis J. H., Bartlett, John M. S.

“…Epithelial mesenchymal transition (EMT) plays an important role in the development of metastases. One of the hallmarks of EMT is loss of E-cadherin and gain of…”
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Tertiary lymphoid structures critical for prognosis in endometrial cancer patients by Horeweg, Nanda, Workel, Hagma H., Loiero, Dominik, Church, David N., Vermij, Lisa, Léon-Castillo, Alicia, Krog, Ricki T., de Boer, Stephanie M., Nout, Remi A., Powell, Melanie E., Mileshkin, Linda R., MacKay, Helen, Leary, Alexandra, Singh, Naveena, Jürgenliemk-Schulz, Ina M., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Koelzer, Viktor H., Nijman, Hans W., Bosse, Tjalling, de Bruyn, Marco

“…B-cells play a key role in cancer suppression, particularly when aggregated in tertiary lymphoid structures (TLS). Here, we investigate the role of B-cells and…”
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Near‐infrared fluorescence‐guided resection of colorectal liver metastases by van der Vorst, Joost R., Schaafsma, Boudewijn E., Hutteman, Merlijn, Verbeek, Floris P. R., Liefers, Gerrit‐Jan, Hartgrink, Henk H., Smit, Vincent T. H. B. M., Löwik, Clemens W. G. M., van de Velde, Cornelis J. H., Frangioni, John V., Vahrmeijer, Alexander L.

“…BACKGROUND The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find…”
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Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer by Mieog, J. Sven D., Troyan, Susan L., Hutteman, Merlijn, Donohoe, Kevin J., van der Vorst, Joost R., Stockdale, Alan, Liefers, Gerrit-Jan, Choi, Hak Soo, Gibbs-Strauss, Summer L., Putter, Hein, Gioux, Sylvain, Kuppen, Peter J. K., Ashitate, Yoshitomo, Löwik, Clemens W. G. M., Smit, Vincent T. H. B. M., Oketokoun, Rafiou, Ngo, Long H., van de Velde, Cornelis J. H., Frangioni, John V., Vahrmeijer, Alexander L.

“…Background Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers…”
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COX2 expression in prognosis and in prediction to endocrine therapy in early breast cancer patients by van Nes, Johanna G. H, de Kruijf, Esther M, Faratian, Dana, van de Velde, Cornelis J. H, Putter, Hein, Falconer, Claire, Smit, Vincent T. H. B. M, Kay, Charlene, van de Vijver, Marc J, Kuppen, Peter J. K, Bartlett, John M. S

“…In breast cancer, the prognostic impact of COX2 expression varies widely between studies. We examined the prognostic value of COX2 expression in a large cohort…”
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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer by Severson, Tesa M., Kim, Yongsoo, Joosten, Stacey E. P., Schuurman, Karianne, van der Groep, Petra, Moelans, Cathy B., ter Hoeve, Natalie D., Manson, Quirine F., Martens, John W., van Deurzen, Carolien H. M., Barbe, Ellis, Hedenfalk, Ingrid, Bult, Peter, Smit, Vincent T. H. B. M., Linn, Sabine C., van Diest, Paul J., Wessels, Lodewyk, Zwart, Wilbert

“…Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment…”
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The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study by Roeke, Toni, Sobral-Leite, Marcelo, Dekker, Tim J. A., Wesseling, Jelle, Smit, Vincent T. H. B. M., Tollenaar, Rob A. E. M., Schmidt, Marjanka K., Mesker, Wilma E.

“…Purpose The primary aim of the current study is to validate the prognostic relevance of the relative amount of tumour-associated stroma, the tumour - stroma…”
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Exploration of tumour-infiltrating lymphocytes as a predictive biomarker for adjuvant endocrine therapy in early breast cancer by Blok, Erik J., Engels, Charla C., Dekker-Ensink, Geeske, Meershoek-Klein Kranenbarg, Elma, Putter, Hein, Smit, Vincent T. H. B. M., Liefers, Gerrit-Jan, Morden, James P., Bliss, Judith M., Coombes, R. Charles, Bartlett, John M. S., Kroep, Judith R., van de Velde, Cornelis J. H., Kuppen, Peter J. K.

“…Purpose Tumour-infiltrating lymphocytes (TILs) have been shown to be prognostic for disease-free survival and predictive for the benefit of chemotherapy in…”
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Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01) by de Groot, Stefanie, Charehbili, Ayoub, van Laarhoven, Hanneke W M, Mooyaart, Antien L, Dekker-Ensink, N Geeske, van de Ven, Saskia, Janssen, Laura G M, Swen, Jesse J, Smit, Vincent T H B M, Heijns, Joan B, Kessels, Lonneke W, van der Straaten, Tahar, Böhringer, Stefan, Gelderblom, Hans, van der Hoeven, Jacobus J M, Guchelaar, Henk-Jan, Pijl, Hanno, Kroep, Judith R

“…The insulin-like growth factor 1 (IGF-1) pathway is involved in cell growth and proliferation and is associated with tumorigenesis and therapy resistance. This…”
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Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy by León-Castillo, Alicia, de Boer, Stephanie M, Powell, Melanie E, Mileshkin, Linda R, Mackay, Helen J, Leary, Alexandra, Nijman, Hans W, Singh, Naveena, Pollock, Pamela M, Bessette, Paul, Fyles, Anthony, Haie-Meder, Christine, Smit, Vincent T H B M, Edmondson, Richard J, Putter, Hein, Kitchener, Henry C, Crosbie, Emma J, de Bruyn, Marco, Nout, Remi A, Horeweg, Nanda, Creutzberg, Carien L, Bosse, Tjalling

“…The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of…”
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Prevalence and Risk Factors of Ovarian Metastases in Breast Cancer Patients < 41 Years of Age in the Netherlands: A Nationwide Retrospective Cohort Study by Peters, Inge T A, van Zwet, Erik W, Smit, Vincent T H B M, Liefers, Gerrit Jan, Kuppen, Peter J K, Hilders, Carina G J M, Trimbos, J Baptist

“…Breast cancer is one of the primary indications for cryopreservation and subsequent autotransplantation of ovarian tissue. The safety of this fertility…”
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Designing a high-throughput somatic mutation profiling panel specifically for gynaecological cancers by Spaans, Vivian M, Trietsch, Marjolijn D, Crobach, Stijn, Stelloo, Ellen, Kremer, Dennis, Osse, Elisabeth M, Haar, Natalja T ter, van Eijk, Ronald, Muller, Susanne, van Wezel, Tom, Trimbos, J Baptist, Bosse, Tjalling, Smit, Vincent T H B M, Fleuren, Gert Jan

“…Somatic mutations play a major role in tumour initiation and progression. The mutation status of a tumour may predict prognosis and guide targeted therapies…”
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Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial by de Boer, Stephanie M, Powell, Melanie E, Mileshkin, Linda, Katsaros, Dionyssios, Bessette, Paul, Haie-Meder, Christine, Ottevanger, Petronella B, Ledermann, Jonathan A, Khaw, Pearly, Colombo, Alessandro, Fyles, Anthony, Baron, Marie-Helene, Jürgenliemk-Schulz, Ina M, Kitchener, Henry C, Nijman, Hans W, Wilson, Godfrey, Brooks, Susan, Carinelli, Silvestro, Provencher, Diane, Hanzen, Chantal, Lutgens, Ludy C H W, Smit, Vincent T H B M, Singh, Naveena, Do, Viet, D'Amico, Romerai, Nout, Remi A, Feeney, Amanda, Verhoeven-Adema, Karen W, Putter, Hein, Creutzberg, Carien L, McCormack, Mary, Whitmarsh, Karen, Allerton, Rozenn, Gregory, Deborah, Symonds, Paul, Hoskin, Peter J., Adusumalli, Madhavi, Anand, Anjana, Wade, Robert, Stewart, Alexandra, Taylor, Wendy, Kruitwagen, Roy F.P.M., Hollema, Harry, Pras, Elizabeth, Snyers, An, Stalpers, Lukas, Jobsen, Jan J., Slot, Annerie, Mens, Jan-Willem M., Stam, Tanja C., Van Triest, Baukelien, Van der Steen - Banasik, Elzbieta M., De Winter, Karin A.J., Quinn, Michael A., Kolodziej, Ilka, Pyman, Jan, Johnson, Carol, Capp, Anne, Fossati, Roldano, Gribaudo, Sergio, Lissoni, Andrea A., Ferrero, Annamaria, Artioli, Grazia, Davidson, Cathy, McLachlin, C. Meg, Ghatage, Prafull, Rittenberg, Paula V.C., Souhami, Luis, Thomas, Gillian, Duvillard, Pierre, Berton-Rigaud, Dominique, Tubiana-Mathieu, Nicole

“…Although women with endometrial cancer generally have a favourable prognosis, those with high-risk disease features are at increased risk of recurrence. The…”
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Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial by de Boer, Stephanie M, MD, Powell, Melanie E, MD, Mileshkin, Linda, MD, Katsaros, Dionyssios, Prof, Bessette, Paul, Prof, Haie-Meder, Christine, MD, Ottevanger, Petronella B, MD, Ledermann, Jonathan A, Prof, Khaw, Pearly, MD, D'Amico, Romerai, MD, Fyles, Anthony, Prof, Baron, Marie-Helene, MD, Jürgenliemk-Schulz, Ina M, PhD, Kitchener, Henry C, Prof, Nijman, Hans W, Prof, Wilson, Godfrey, MD, Brooks, Susan, MD, Gribaudo, Sergio, MD, Provencher, Diane, Prof, Hanzen, Chantal, MD, Kruitwagen, Roy F, Prof, Smit, Vincent T H B M, Prof, Singh, Naveena, MD, Do, Viet, MD, Lissoni, Andrea, MD, Nout, Remi A, MD, Feeney, Amanda, MSc, Verhoeven-Adema, Karen W, PhD, Putter, Hein, Prof, Creutzberg, Carien L, Prof

“…SummaryBackgroundThe PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy versus pelvic radiotherapy alone for women with…”
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Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial by de Groot, Stefanie, Lugtenberg, Rieneke T., Cohen, Danielle, Welters, Marij J. P., Ehsan, Ilina, Vreeswijk, Maaike P. G., Smit, Vincent T. H. B. M., de Graaf, Hiltje, Heijns, Joan B., Portielje, Johanneke E. A., van de Wouw, Agnes J., Imholz, Alex L. T., Kessels, Lonneke W., Vrijaldenhoven, Suzan, Baars, Arnold, Kranenbarg, Elma Meershoek-Klein, Carpentier, Marjolijn Duijm-de, Putter, Hein, van der Hoeven, Jacobus J. M., Nortier, Johan W. R., Longo, Valter D., Pijl, Hanno, Kroep, Judith R.

“…Short-term fasting protects tumor-bearing mice against the toxic effects of chemotherapy while enhancing therapeutic efficacy. We randomized 131 patients with…”
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Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer by Mieog, J. Sven D., Hutteman, Merlijn, van der Vorst, Joost R., Kuppen, Peter J. K., Que, Ivo, Dijkstra, Jouke, Kaijzel, Eric L., Prins, Frans, Löwik, Clemens W. G. M., Smit, Vincent T. H. B. M., van de Velde, Cornelis J. H., Vahrmeijer, Alexander L.

“…Tumor involvement of resection margins is found in a large proportion of patients who undergo breast-conserving surgery. Near-infrared (NIR) fluorescence…”
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The clinical value of HER-2 overexpression and PIK3CA mutations in the older breast cancer population: a FOCUS study analysis by Engels, Charla C., Kiderlen, Mandy, Bastiaannet, Esther, van Eijk, Ronald, Mooyaart, Antien, Smit, Vincent T. H. B. M., de Craen, Anton J. M., Kuppen, Peter J. K., Kroep, Judith R., van de Velde, Cornelis J. H., Liefers, Gerrit Jan

“…Studies to confirm the effect of acknowledged prognostic markers in older breast cancer patients are scarce. The aim of this study was to evaluate the…”
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Prognostic significance of POLE proofreading mutations in endometrial cancer by Church, David N, Stelloo, Ellen, Nout, Remi A, Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P M, Wild, Peter J, Lambrechts, Diether, Jürgenliemk-Schulz, Ina M, Jobsen, Jan J, Smit, Vincent T H B M, Creutzberg, Carien L, Bosse, Tjalling

“…Current risk stratification in endometrial cancer (EC) results in frequent over- and underuse of adjuvant therapy, and may be improved by novel biomarkers. We…”
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