Search Results - "Smit, Johannes W.A."

Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus by Rijzewijk, Luuk J., MD, van der Meer, Rutger W., MD, Smit, Johannes W.A., MD, PhD, Diamant, Michaela, MD, PhD, Bax, Jeroen J., MD, PhD, Hammer, Sebastiaan, MSc, Romijn, Johannes A., MD, PhD, de Roos, Albert, MD, PhD, Lamb, Hildo J., MD, PhD

“…Objectives The purpose of this study was to compare myocardial triglyceride content and function between patients with uncomplicated type 2 diabetes mellitus…”
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Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function by Hammer, Sebastiaan, MSc, Snel, Marieke, MD, Lamb, Hildo J., MD, PhD, Jazet, Ingrid M., MD, PhD, van der Meer, Rutger W., MD, Pijl, Hanno, MD, PhD, Meinders, Edo A., MD, PhD, Romijn, Johannes A., MD, PhD, de Roos, Albert, MD, PhD, Smit, Johannes W.A., MD, PhD

“…Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function…”
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Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development by Georgiadi, Anastasia, Wang, Yanan, Stienstra, Rinke, Tjeerdema, Nathanja, Janssen, Aafke, Stalenhoef, Anton, van der Vliet, J Adam, de Roos, Albert, Tamsma, Jouke T, Smit, Johannes W.A, Tan, Nguan Soon, Müller, Michael, Rensen, Patrick C.N, Kersten, Sander

“…OBJECTIVE—Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis…”
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Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study by Gast, Karin B, den Heijer, Martin, Smit, Johannes W.A, Widya, Ralph L, Lamb, Hildo J, de Roos, Albert, Jukema, J. Wouter, Rosendaal, Frits R, de Mutsert, Renée

“…Abstract Background Both overall and abdominal adiposity are established risk factors for cardiovascular disease. Visceral adipose tissue (VAT) and total body…”
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Right Ventricular Involvement in Diabetic Cardiomyopathy by WIDYA, Ralph L, VAN DER MEER, Rutger W, SMIT, Johannes W. A, RIJZEWIJK, Luuk J, DIAMANT, Michaela, BAX, Jeroen J, DE ROOS, Albert, LAMB, Hildo J

“…To compare magnetic resonance imaging-derived right ventricular (RV) dimensions and function between men with type 2 diabetes and healthy subjects, and to…”
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Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects by VAN DER MEER, Rutger W, HAMMER, Sebastiaan, SMIT, Johannes W. A, FRÖLICH, Marijke, BAX, Jeroen J, DIAMANT, Michaela, RIJZEWIJK, Luuk J, DE ROOS, Albert, ROMIJN, Johannes A, LAMB, Hildo J

“…Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects Rutger W…”
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Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship by Netea-Maier, Romana T., Smit, Johannes W.A., Netea, Mihai G.

“…In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building…”
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The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations by Sterenborg, Rosalie B T M, Galesloot, Tessel E, Teumer, Alexander, Netea-Maier, Romana T, Speed, Doug, Meima, Marcel E, Visser, W Edward, Smit, Johannes W A, Peeters, Robin P, Medici, Marco

“…While most of the variation in thyroid function is determined by genetic factors, single nucleotide polymorphisms (SNPs) identified via genome-wide association…”
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Differences in Inflammatory Pathways Between Dutch South Asians vs Dutch Europids With Type 2 Diabetes by Straat, Maaike E, Martinez-Tellez, Borja, van Eyk, Huub J, Bizino, Maurice B, van Veen, Suzanne, Vianello, Eleonora, Stienstra, Rinke, Ottenhoff, Tom H M, Lamb, Hildo J, Smit, Johannes W A, Jazet, Ingrid M, Rensen, Patrick C N, Boon, Mariëtte R

“…Abstract Context South Asian individuals are more prone to develop type 2 diabetes (T2D) coinciding with earlier complications than Europids. While…”
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Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy: Studies With Cardiac Positron Emission Tomography and Magnetic Resonance Imaging by RIJZEWIJK, Luuk J, VAN DER MEER, Rutger W, LAMMERTSMA, Adriaan A, SMIT, Johannes W. A, DIAMANT, Michaela, LAMB, Hildo J, DE JONG, Hugo W. A. M, LUBBERINK, Mark, ROMIJN, Johannes A, BAX, Jeroen J, DE ROOS, Albert, TWISK, Jos W, HEINE, Robert J

“…This study was designed to evaluate myocardial substrate and high-energy phosphate (HEP) metabolism in asymptomatic men with well-controlled, uncomplicated…”
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Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function by Hammer, Sebastiaan, Jonker, Jacqueline T, Lamb, Hildo J, van der Meer, Rutger W, Zondag, Wendy, Sepers, Jan M, de Roos, Albert, Smit, Johannes W.A, Romijn, Johannes A

“…OBJECTIVE:--To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in…”
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Pioglitazone Improves Cardiac Function and Alters Myocardial Substrate Metabolism Without Affecting Cardiac Triglyceride Accumulation and High-Energy Phosphate Metabolism in Patients With Well-Controlled Type 2 Diabetes Mellitus by VAN DER MEER, Rutger W, RIJZEWIJK, Luuk J, HEINE, Robert J, LAMMERTSMA, Adriaan A, SMIT, Johannes W. A, DIAMANT, Michaela, DE JONG, Hugo W. A. M, LAMB, Hildo J, LUBBERINK, Mark, ROMIJN, Johannes A, BAX, Jeroen J, DE ROOS, Albert, KAMP, Otto, PAULUS, Walter J

“…Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also…”
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Findings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients With Type 2 Diabetes Mellitus by Ng, Arnold C.T., MBBS, Delgado, Victoria, MD, Bertini, Matteo, MD, van der Meer, Rutger W., MD, Rijzewijk, Luuk J., MD, Shanks, Miriam, MD, Nucifora, Gaetano, MD, Smit, Johannes W.A., MD, PhD, Diamant, Michaela, MD, PhD, Romijn, Johannes A., MD, PhD, de Roos, Albert, MD, PhD, Leung, Dominic Y., MBBS, PhD, Lamb, Hildo J., MD, PhD, Bax, Jeroen J., MD, PhD

“…Regional left ventricular (LV) myocardial functional changes in early diabetic cardiomyopathy have not been well documented. LV multidirectional strain and…”
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The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment by Wolters, Thalijn L C, Roerink, Sean H P P, Drenthen, Linda C A, van Haren-Willems, Jolanda H G M, Wagenmakers, Margaretha A E M, Smit, Johannes W A, Hermus, Adrianus R M M, Netea-Maier, Romana T

“…Abstract Background Obstructive sleep apnea syndrome (OSAS) is common in active acromegaly and negatively influences quality of life, morbidity, and mortality…”
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No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials by Du Puy, Robert S, Poortvliet, Rosalinde K E, Mooijaart, Simon P, Stott, David J, Quinn, Terry, Sattar, Naveed, Westendorp, Rudi G J, Kearney, Patricia M, McCarthy, Vera J C, Byrne, Stephen, Rodondi, Nicolas, Baretella, Oliver, Collet, Tinh-Hai, van Heemst, Diana, Dekkers, Olaf M, Jukema, J Wouter, Smit, Johannes W A, Gussekloo, Jacobijn, den Elzen, Wendy P J

“…Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. The aim of this study was to assess…”
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Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells by Wang, Yanan, van der Tuin, Sam, Tjeerdema, Nathanja, van Dam, Andrea D., Rensen, Sander S., Hendrikx, Tim, Berbée, Jimmy F.P., Atanasovska, Biljana, Fu, Jingyuan, Hoekstra, Menno, Bekkering, Siroon, Riksen, Niels P., Buurman, Wim A., Greve, Jan Willem, Hofker, Marten H., Shiri‐Sverdlov, Ronit, Meijer, Onno C., Smit, Johannes W.A., Havekes, Louis M., van Dijk, Ko Willems, Rensen, Patrick C.N.

“…The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established. Nevertheless, KCs have been underexplored as a target for…”
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Bone morphogenetic protein 7: A broad-spectrum growth factor with multiple target therapeutic potency by Boon, Mariëtte R, van der Horst, Geertje, van der Pluijm, Gabri, Tamsma, Jouke T, Smit, Johannes W.A, Rensen, Patrick C.N

“…Abstract Bone morphogenetic protein 7 (BMP7) is a member of the transforming growth factor-β (TGF-β) superfamily of growth factors. In recent years, it has…”
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Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy by Rijzewijk, Luuk J., MD, van der Meer, Rutger W., MD, PhD, Lamb, Hildo J., MD, PhD, de Jong, Hugo W.A.M., PhD, Lubberink, Mark, PhD, Romijn, Johannes A., MD, PhD, Bax, Jeroen J., MD, PhD, de Roos, Albert, MD, PhD, Twisk, Jos W., PhD, Heine, Robert J., MD, PhD, Lammertsma, Adriaan A., PhD, Smit, Johannes W.A., MD, PhD, Diamant, Michaela, MD, PhD

“…Objectives This study was designed to evaluate myocardial substrate and high-energy phosphate (HEP) metabolism in asymptomatic men with well-controlled,…”
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A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men by Bakker, Leontine E H, van Schinkel, Linda D, Guigas, Bruno, Streefland, Trea C M, Jonker, Jacqueline T, van Klinken, Jan B, van der Zon, Gerard C M, Lamb, Hildo J, Smit, Johannes W A, Pijl, Hanno, Meinders, A Edo, Jazet, Ingrid M

“…South Asians (SAs) develop type 2 diabetes at a younger age and lower BMI compared with Caucasians (Cs). The underlying cause is still poorly understood but…”
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Long‐Term Beneficial Effect of a 16‐Week Very Low Calorie Diet on Pericardial Fat in Obese Type 2 Diabetes Mellitus Patients by Snel, Marieke, Jonker, Jacqueline T., Hammer, Sebastian, Kerpershoek, Gijs, Lamb, Hildo J., Meinders, A. Edo, Pijl, Hanno, Roos, Albert, Romijn, Johannes A., Smit, Johannes W.A., Jazet, Ingrid M.

“…Pericardial fat accumulation has been associated with an increased cardiovascular risk. A very low calorie diet (VLCD) improves the cardiovascular risk profile…”
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