Search Results - "Smisek, Petr"

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia by Khalil, Alaeddin, Würthwein, Gudrun, Golitsch, Jana, Hempel, Georg, Fobker, Manfred, Gerss, Joachim, Möricke, Anja, Zimmermann, Martin, Smisek, Petr, Zucchetti, Massimo, Nath, Christa, Attarbaschi, Andishe, Von Stackelberg, Arend, Gökbuget, Nicola, Rizzari, Carmelo, Conter, Valentino, Schrappe, Martin, Boos, Joachim, Lanvers-Kaminsky, Claudia

“…Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. We evaluated the prevalence of…”
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Improved Outcome in Pediatric Relapsed Acute Myeloid Leukemia: Results of a Randomized Trial on Liposomal Daunorubicin by the International BFM Study Group by KASPERS, Gertjan J. L, ZIMMERMANN, Martin, HOVI, Liisa, MASCHAN, Alexei, BERTRAND, Yves, LEVERGER, Guy G, RAZZOUK, Bassem I, RIZZARI, Carmelo, SMISEK, Petr, SMITH, Owen, STARK, Batia, CREUTZIG, Ursula, REINHARDT, Dirk, GIBSON, Brenda E. S, TAMMINGA, Rienk Y. J, ALEINIKOVA, Olga, ARMENDARIZ, Hortensia, DWORZAK, Michael, HA, Shau-Yin, HASLE, Henrik

“…In pediatric relapsed acute myeloid leukemia (AML), optimal reinduction therapy is unknown. Studies suggest that liposomal daunorubicin (DNX; DaunoXome; Galen,…”
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Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study by Rizzari, Carmelo, Lanvers-Kaminsky, Claudia, Valsecchi, Maria Grazia, Ballerini, Andrea, Matteo, Cristina, Gerss, Joachim, Wuerthwein, Gudrun, Silvestri, Daniela, Colombini, Antonella, Conter, Valentino, Biondi, Andrea, Schrappe, Martin, Moericke, Anja, Zimmermann, Martin, von Stackelberg, Arend, Linderkamp, Christin, Frühwald, Michael C, Legien, Sabine, Attarbaschi, Andishe, Reismüller, Bettina, Kasper, David, Smisek, Petr, Stary, Jan, Vinti, Luciana, Barisone, Elena, Parasole, Rosanna, Micalizzi, Concetta, Zucchetti, Massimo, Boos, Joachim

“…Asparagine levels in cerebrospinal fluid and serum asparaginase activity were monitored in children with acute lymphoblastic leukemia treated with…”
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Guideline for management of non-Down syndrome neonates with a myeloproliferative disease on behalf of the I-BFM AML Study Group and EWOG-MDS by Bertrums, Eline J M, Zwaan, C Michel, Hasegawa, Daisuke, De Haas, Valerie, Reinhardt, Dirk N, Locatelli, Franco, De Moerloose, Barbara, Dworzak, Michael, Buijs, Arjan, Smisek, Petr, Kolenova, Alexandra, Pronk, Cornelis Jan, Klusmann, Jan-Henning, Carboné, Ana, Ferster, Alina, Antoniou, Evangelia, Meshinchi, Soheil, Raimondi, Susana C, Niemeyer, Charlotte M, Hasle, Henrik, Van den Heuvel-Eibrink, Marry M, Goemans, Bianca F

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The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01 by Creutzig, Ursula, Zimmermann, Martin, Dworzak, Michael N, Gibson, Brenda, Tamminga, Rienk, Abrahamsson, Jonas, Ha, Shau-Yin, Hasle, Henrik, Maschan, Alexey, Bertrand, Yves, Leverger, Guy, von Neuhoff, Christine, Razzouk, Bassem, Rizzari, Carmelo, Smisek, Petr, Smith, Owen P, Stark, Batia, Reinhardt, Dirk, Kaspers, Gertjan L

“…The prognostic significance of early response to treatment has not been reported in relapsed pediatric acute myeloid leukemia. In order to identify an early…”
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Four Additional Doses of PEG-L-Asparaginase During the Consolidation Phase in the AIEOP-BFM ALL 2009 Protocol Do Not Improve Outcome and Increase Toxicity in High-Risk ALL: Results of a Randomized Study by Conter, Valentino, Valsecchi, Maria Grazia, Cario, Gunnar, Zimmermann, Martin, Attarbaschi, Andishe, Stary, Jan, Niggli, Felix, Dalla Pozza, Luciano, Elitzur, Sarah, Silvestri, Daniela, Locatelli, Franco, Möricke, Anja, Engstler, Gernot, Smisek, Petr, Bodmer, Nicole, Barbaric, Draga, Izraeli, Shai, Rizzari, Carmelo, Boos, Joachim, Buldini, Barbara, Zucchetti, Massimo, von Stackelberg, Arend, Matteo, Cristina, Lehrnbecher, Thomas, Lanvers-Kaminsky, Claudia, Cazzaniga, Giovanni, Gruhn, Bernd, Biondi, Andrea, Schrappe, Martin

“…The AIEOP-BFM ALL 2009 protocol included, at the end of the induction phase, a randomized study of patients with high-risk (HR) ALL to investigate if an…”
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A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS by Maccari, Maria Elena, Fuchs, Sebastian, Kury, Patrick, Andrieux, Geoffroy, Völkl, Simon, Bengsch, Bertram, Lorenz, Myriam Ricarda, Heeg, Maximilian, Rohr, Jan, Jägle, Sabine, Castro, Carla N, Groß, Miriam, Warthorst, Ursula, König, Christoph, Fuchs, Ilka, Speckmann, Carsten, Thalhammer, Julian, Kapp, Friedrich G, Seidel, Markus G, Dückers, Gregor, Schönberger, Stefan, Schütz, Catharina, Führer, Marita, Kobbe, Robin, Holzinger, Dirk, Klemann, Christian, Smisek, Petr, Owens, Stephen, Horneff, Gerd, Kolb, Reinhard, Naumann-Bartsch, Nora, Miano, Maurizio, Staniek, Julian, Rizzi, Marta, Kalina, Tomas, Schneider, Pascal, Erxleben, Anika, Backofen, Rolf, Ekici, Arif, Niemeyer, Charlotte M, Warnatz, Klaus, Grimbacher, Bodo, Eibel, Hermann, Mackensen, Andreas, Frei, Andreas Philipp, Schwarz, Klaus, Boerries, Melanie, Ehl, Stephan, Rensing-Ehl, Anne

“…The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific…”
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A homozygous deletion in the SLC19A1 gene as a cause of folate-dependent recurrent megaloblastic anemia by Svaton, Michael, Skvarova Kramarzova, Karolina, Kanderova, Veronika, Mancikova, Andrea, Smisek, Petr, Jesina, Pavel, Krijt, Jakub, Stiburkova, Blanka, Dobrovolny, Robert, Sokolova, Jitka, Bakardjieva-Mihaylova, Violeta, Vodickova, Elena, Rackova, Marketa, Stuchly, Jan, Kalina, Tomas, Stary, Jan, Trka, Jan, Fronkova, Eva, Kozich, Viktor

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Impact of Additional Intensive L-Asparaginase Therapy during Consolidation Phase for High-Risk Acute Lymphoblastic Leukemia: Results of a Randomized Controlled Trial in the AIEOP-BFM ALL 2009 Protocol by Conter, Valentino, Valsecchi, Maria Grazia, Cario, Gunnar, Zimmermann, Martin, Attarbaschi, Andishe, Stary, Jan, Niggli, Felix, Dalla Pozza, Luciano, Elitzur, Sarah, Silvestri, Daniela, Locatelli, Franco, Moericke, Anja, Engstler, Gernot, Smisek, Petr, Bodmer, Nicole, Barbaric, Draga, Izraeli, Shai, Rizzari, Carmelo, Boos, Joachim, Buldini, Barbara, Lanvers-Kaminsky, Claudia, Cazzaniga, Giovanni, Gruhn, Bernd, Biondi, Andrea, Schrappe, Martin

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Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study by Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, Gerss, Joachim, Möricke, Anja, Zimmermann, Martin, Stary, Jan, Smisek, Petr, Attarbaschi, Andishe, Nath, Christa, Zucchetti, Massimo, Rizzari, Carmelo, Schrappe, Martin, Boos, Joachim

“…Therapeutic drug monitoring (TDM) can identify patients with subtherapeutic asparaginase (ASNase) activity [silent inactivation (SI)] and prospectively guide…”
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Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach by Siebel, Christian, Lanvers-Kaminsky, Claudia, Alten, Julia, Smisek, Petr, Nath, Christa E., Rizzari, Carmelo, Boos, Joachim, Würthwein, Gudrun

“…Background and Objectives Besides allergic reactions, antibodies against polyethylene glycol (PEG) have been associated with reduced PEG-asparaginase…”
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Folate-Dependent Normocytic Anemia Caused By a Hypomorphic Mutation in SLC19A1 gene by Svaton, Michael, Skvarova Kramarzova, Karolina, Kanderova, Veronika, Smisek, Petr, Jesina, Pavel, Krijt, Jakub, Stiburkova, Blanka, Mancikova, Andrea, Dobrovolny, Robert, Bakardjieva-Mihaylova, Violeta, Vodickova, Elena, Stuchly, Jan, Kalina, Tomas, Stary, Jan, Trka, Jan, Fronkova, Eva, Kozich, Viktor

“…Next generation sequencing has enabled rapid diagnosis of patients with monogenic diseases and discovery of novel disease-causing variants. However, the…”
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Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data by Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, Siebel, Christian, Gerß, Joachim, Möricke, Anja, Zimmermann, Martin, Stary, Jan, Smisek, Petr, Schrappe, Martin, Rizzari, Carmelo, Zucchetti, Massimo, Hempel, Georg, Wicha, Sebastian G., Boos, Joachim

“…Background and Objectives The pharmacokinetics of polyethylene glycol-conjugated asparaginase (PEG-ASNase) are characterized by an increase in elimination over…”
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Therapeutic Drug Monitoring of Asparaginase Activity-Method Comparison of MAAT and AHA Test Used in the International AIEOP-BFM ALL 2009 Trial by Lanvers-Kaminsky, Claudia, Rüffer, Andrea, Würthwein, Gudrun, Gerss, Joachim, Zucchetti, Massimo, Ballerini, Andrea, Attarbaschi, Andishe, Smisek, Petr, Nath, Christa, Lee, Samiuela, Elitzur, Sara, Zimmermann, Martin, Möricke, Anja, Schrappe, Martin, Rizzari, Carmelo, Boos, Joachim

“…In the international AIEOP-BFM ALL 2009 trial, asparaginase (ASE) activity was monitored after each dose of pegylated Escherichia coli ASE (PEG-ASE). Two…”
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The Prognostic Impact of Cytogenetics and Karyotype Changes in Pediatric Patients with Relapsed Acute Myeloid Leukemia: A Retrospective Cohort Study within the Relapsed AML 2001/01 Study by Klein, Kim, Zimmermann, Martin, Beverloo, Berna, von Neuhoff, Christine, De Haas, Valerie, van Weelderen, Romy, Raimondi, Susana C., Cloos, Jacqueline, Abrahamsson, Jonas, Bertrand, Yves, Dworzak, Michael, Elitzur, Sarah, Fynn, Alcira, Gibson, Brenda, Ha, Shau Yin, Harrison, Christine, Hasle, Henrik, Leverger, Guy, Maschan, Alexey, Razzouk, Bassem I., Reinhardt, Dirk, Rizzari, Carmelo, Smisek, Petr, Creutzig, Ursula, Kaspers, Gertjan J.L.

“…Introduction After treatment response, cytogenetics and molecular aberrations are the most important prognostic factors in children with de novo acute myeloid…”
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Fanconi anemia with biallelic FANCD1 / BRCA2 mutations – Case report of a family with three affected children by Svojgr, Karel, Sumerauer, David, Puchmajerova, Alena, Vicha, Ales, Hrusak, Ondrej, Michalova, Kyra, Malis, Josef, Smisek, Petr, Kyncl, Martin, Novotna, Drahuse, Machackova, Eva, Jencik, Jan, Pycha, Karel, Vaculik, Miroslav, Kodet, Roman, Stary, Jan

“…Abstract Fanconi anemia, complementation group D1 with bi-allelic FANCD1 ( BRCA2) mutations, is a very rare genetic disorder characterized by early onset of…”
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Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia by Rensing-Ehl, Anne, Janda, Ales, Lorenz, Myriam R, Gladstone, Beryl P, Fuchs, Ilka, Abinun, Mario, Albert, Michael, Butler, Karina, Cant, Andrew, Cseh, Anna-Maria, Ebinger, Martin, Goldacker, Sigune, Hambleton, Sophie, Hebart, Holger, Houet, Leonora, Kentouche, Karim, Kühnle, Ingrid, Lehmberg, Kai, Mejstrikova, Ester, Niemeyer, Charlotte, Minkov, Milen, Neth, Olaf, Dückers, Gregor, Owens, Stephan, Rösler, Joachim, Schilling, Freimut H, Schuster, Volker, Seidel, Markus G, Smisek, Petr, Sukova, Martina, Svec, Peter, Wiesel, Thomas, Gathmann, Benjamin, Schwarz, Klaus, Vach, Werner, Ehl, Stephan, Speckmann, Carsten

“…Clinical and genetic heterogeneity renders confirmation or exclusion of autoimmune lymphoproliferative syndrome difficult. To re-evaluate and improve the…”
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Jumping translocations in bone marrow cells of pediatric patients with hematologic malignancies: a rare cytogenetic phenomenon by Lizcova, Libuse, Zemanova, Zuzana, Malinova, Eva, Michalova, Kyra, Smisek, Petr, Stary, Jan

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B Precursor ALL Subset with Aberrant CD2 Expression and a Specific Predisposition to Early Monocytic Transdifferentiation by Mejstrikova, Ester, Slamova, Lucie, Fronkova, Eva, Zuna, Jan, Bourquin, Jean-Pierre, Vodickova, Elena, Muzikova, Katerina, Zemanova, Zuzana, Pelkova, Vendula, Van Delft, Frederik, Kalina, Tomas, Fiser, Karel, Smisek, Petr, Trka, Jan, Stary, Jan, Hrusak, Ondrej

“…Abstract 1708 Anecdotic observations of B precursor (BCP) ALL patients with aberrant CD2 expression at diagnosis and a significant shift of phenotype towards…”
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Central Nervous System (CNS) Involvement In Pediatric Relapsed Acute Myeloid Leukemia: Results and Lessons From Study Relapsed AML 2001/01 by Kaspers, Gertjan, Zimmermann, Martin, Reinhardt, Dirk, Gibson, Brenda, Tamminga, Rienk, Aleinikova, Olga, Armendariz, Hortensia, Dworzak, Michael, Ha, S., Hovi, Lisa, Maschan, Alexei, Baruchel, Andre, Bertrand, Yves, Razzouk, Bassem, Rizzari, Carmelo, Smisek, Petr, Smith, Owen, Stark, Batia, Creutzig, Ursula

“…Abstract 184 Acute Myeloid Leukemia - Therapy, excluding Transplantation: Pediatric and Adult AML Therapy With improving initial antileukemic therapy, CNS…”
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