Search Results - "Smisek, David L"

Bile acid binding to sevelamer HCl by Braunlin, William, Zhorov, Eugene, Guo, Amy, Apruzzese, William, Xu, Qiuwei, Hook, Patrick, Smisek, David L., Mandeville, W. Harry, Holmes-Farley, S. Randall

“…Bile acid binding to sevelamer HCl. Clinical studies have shown sevelamer HCl (Renagel®) to be effective for the reduction of serum phosphate in hemodialysis…”
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Electrophoresis of Flexible Macromolecules: Evidence for a New Mode of Transport in Gels by Smisek, David L., Hoagland, David A.

“…Movement of macromolecules through low concentration agarose gels was investigated with linear poly(styrenesulfonate), linear DNA, star-shaped…”
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Separation of quaternary ammonium diastereomeric oligomers by capillary electrophoresis by Zhang, Bin, Krull, Ira S, Cohen, Aharon, Smisek, David L, Kloss, Alla, Wang, Bing, Bourque, Andre J

“…The separation of novel diastereomeric trimers (3M) and pentamers (5M), derived from quaternary ammonium salts, was studied in conventional, uncoated and…”
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Gel and free solution electrophoresis of variably charged polymers by Hoagland, D A, Smisek, D L, Chen, D Y

“…To assess the role of charge density on polyelectrolyte mobility, both gel and free solution electrophoresis experiments are performed on poly(acrylic acid)…”
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Agarose gel electrophoresis of high molecular weight, synthetic polyelectrolytes by Smisek, David L, Hoagland, David A

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Study of phosphorothioate-modified oligonucleotide resistance to 3′-exonuclease using capillary electrophoresis by Gilar, Martin, Belenky, Alexei, Budman, Yeva, Smisek, David L, Cohen, Aharon S

“…The effect of phosphorothioate (PS) internucleotide linkages on the stability of phosphodiester oligodeoxyribonucleotides (ODNs) was investigated using 25-mer…”
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Capillary electrophoresis with polymeric separation media: considerations for theory by Smisek, D L

“…The theory of capillary electrophoresis with polymeric separation media is reviewed. Some of the major theories of gel electrophoresis are examined in terms of…”
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Sequencing of antisense DNA analogues by capillary gel electrophoresis with laser-induced fluorescence detection by Belenky, Alexei, Smisek, David L., Cohen, Aharon S.

“…A method using capillary gel electrophoresis with laser-induced fluorescence detection is described which permits complete sequence determination of antisense…”
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Electrophoresis of flexible macromolecules: evidence for a mew mode of transport in gels by Smisek, David L, Hoagland, David A

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Emerging technologies for sequencing antisense oligonucleotides: capillary electrophoresis and mass spectrometry by Cohen, A S, Smisek, D L, Wang, B H

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Impact of 3'-exonuclease stereoselectivity on the kinetics of phosphorothioate oligonucleotide metabolism by Gilar, M, Belenky, A, Budman, Y, Smisek, D L, Cohen, A S

“…For the enzymatic digestion of a 25-mer phosphorothioate (PS) oligonucleotide, the reaction kinetics was previously determined to be the sum of two parallel…”
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A nonradioisotope approach to study the in vivo metabolism of phosphorothioate oligonucleotides by Cohen, A S, Bourque, A J, Wang, B H, Smisek, D L, Belenky, A

“…A 25-mer phosphorothioate oligodeoxynucleotide (GEM 91) complementary to the gag gene mRNA of HIV-1 virus was administered intravenously (i.v.) at a dose of 10…”
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