The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction

The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction

Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse. The aim of this study was to evaluat...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine Vol. 9; pp. 89 - 95
Main Authors: Sychev, Dmitry Alekseevich, Zastrozhin, Mikhail Sergeevich, Smirnov, Valery Valerieevich, Grishina, Elena Anatolievna, Savchenko, Ludmila Mikhailovna, Bryun, Evgeny Alekseevich
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2016
Taylor & Francis Ltd
Dove Medical Press
Subjects:
Addictions
Alcohol abuse
alcohol addiction
Alcoholism
Anxiety
biotransformation
Care and treatment
CYP2D6
Cytochrome P-450
Drug dosages
Enzymes
Haloperidol
Isoenzymes
Metabolism
Metabolites
Original Research
Polymorphism
Psychotropic drugs
Public health
Schizophrenia
side effects
Substance abuse treatment
United States > US
Russia
haloperidol
side effects
alcohol addiction
biotransformation
CYP2D6
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Summary:Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse. The aim of this study was to evaluate the correlation between the activity of CYP2D6 and the efficacy and safety of haloperidol in patients with diagnosed alcohol abuse. The study involved 70 men (average age: 40.83±9.92 years) with alcohol addiction. A series of psychometric scales were used in the research. The activity of CYP2D6 was evaluated by high-performance liquid chromatography with mass spectrometry using the ratio of 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline to pinoline. Genotyping of CYP2D6 (1846G>A) was performed using real-time polymerase chain reaction. According to results of correlation analysis, statistically significant values of Spearman correlation coefficient ( ) between the activity of CYP2D6 and the difference of points in psychometric scale were obtained in patients receiving haloperidol in injection form (Sheehan Clinical Anxiety Rating Scale =-0.721 [ <0.001] and Udvald for Kliniske Undersogelser Side Effect Rating Scale =0.692 [ <0.001]) and in those receiving haloperidol in tablet form (Covi Anxiety Scale =-0.851 [ <0.001] and Udvald for Kliniske Undersogelser Side Effect Rating Scale =0.797 [ <0.001]). This study demonstrated the correlations between the activity of CYP2D6 isozyme and the efficacy and safety of haloperidol in patients with alcohol addiction.
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ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S110385