Search Results - "Smink, Alexandra M"

Acetate and Butyrate Improve β-cell Metabolism and Mitochondrial Respiration under Oxidative Stress by Hu, Shuxian, Kuwabara, Rei, de Haan, Bart J, Smink, Alexandra M, de Vos, Paul

“…Islet dysfunction mediated by oxidative and mitochondrial stress contributes to the development of type 1 and 2 diabetes. Acetate and butyrate, produced by gut…”
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Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation by Liu, Qingsheng, Chiu, Alan, Wang, Long-Hai, An, Duo, Zhong, Monica, Smink, Alexandra M., de Haan, Bart J., de Vos, Paul, Keane, Kevin, Vegge, Andreas, Chen, Esther Y., Song, Wei, Liu, Wendy F., Flanders, James, Rescan, Claude, Grunnet, Lars Groth, Wang, Xi, Ma, Minglin

“…Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and can compromise the function of implants or cause complications. For…”
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The directed differentiation of human iPS cells into kidney podocytes by Song, Bi, Smink, Alexandra M, Jones, Christina V, Callaghan, Judy M, Firth, Stephen D, Bernard, Claude A, Laslett, Andrew L, Kerr, Peter G, Ricardo, Sharon D

“…The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are…”
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A Retrievable, Efficacious Polymeric Scaffold for Subcutaneous Transplantation of Rat Pancreatic Islets by Smink, Alexandra M, Hertsig, Don T, Schwab, Leendert, van Apeldoorn, Aart A, de Koning, Eelco, Faas, Marijke M, de Haan, Bart J, de Vos, Paul

“…OBJECTIVE:We aim on developing a polymeric ectopic scaffold in a readily accessible site under the skin. SUMMARY BACKGROUND DATA:The liver as transplantation…”
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Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials by Eslami-Kaliji, Farshid, Hedayat Nia, Niloufar, Lakey, Jonathan R T, Smink, Alexandra M, Mohammadi, Mohammadreza

“…Long term function of implantable biomaterials are determined by their integration with the host's body. Immune reactions against these implants could impair…”
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Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence by de Vos, Paul, Smink, Alexandra M, Paredes, Genaro, Lakey, Jonathan R T, Kuipers, Jeroen, Giepmans, Ben N G, de Haan, Bart J, Faas, Marijke M

“…The primary aim of this study was to determine whether normal variations in enzyme-activities of collagenases applied for rat-islet isolation impact longevity…”
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Successful Islet Transplantation Into a Subcutaneous Polycaprolactone Scaffold in Mice and Pigs by Smink, Alexandra M., Rodriquez, Samuel, Li, Shiri, Ceballos, Bryan, Corrales, Nicole, Alexander, Michael, Koster, Taco, de Haan, Bart J., Lakey, Jonathan R.T., de Vos, Paul

“…Islet transplantation is a promising treatment for type 1 diabetes. It has the potential to improve glycemic control, particularly in patients suffering from…”
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In vitro determination of the immunosuppressive effect, internalization, and release mechanism of squalene-gusperimus nanoparticles for managing inflammatory responses by Navarro Chica, Carlos E., Qin, Tian, de Haan, Bart J., Faas, M.M, Smink, Alexandra M., Sierra, Ligia, López, Betty L., de Vos, Paul

“…Gusperimus is an anti-inflammatory drug that has shown to be effective in managing autoimmunity and preventing graft rejection. This is unstable and easily…”
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Impact of Exogenous Nitric Oxide Treatment on Vascularization of a Subcutaneous Device for Cell Transplantation by Smink, Alexandra M., Ceballos, Bryan, Koster, Taco, Rodriquez, Samuel, Alexander, Michael, Lakey, Jonathan R. T., de Vos, Paul

“…Subcutaneous polymer scaffolds have shown potential for creating an optimal transplantation site in cellular replacement therapy, e.g., when transplanting…”
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In Vitro Studies of Squalene‐Gusperimus Nanoparticles in Islet‐Containing Alginate Microcapsules to Regulate the Immune Response in the Immediate Posttransplant Period by Navarro Chica, Carlos E., Qin, Tian, de Haan, Bart J., Faas, Marijke M., Smink, Alexandra M., Sierra, Ligia, López, Betty L., de Vos, Paul

“…Grafting of microencapsulated pancreatic islets has been proposed as an alternative to exogenous insulin for the treatment of type 1 diabetes mellitus…”
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Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment by Qin, Tian, Smink, Alexandra M., de Vos, Paul

“…Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated…”
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Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation by Smink, Alexandra M., de Vos, Paul

“…Purposes of Review Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to…”
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The Effect of a Fast-Releasing Hydrogen Sulfide Donor on Vascularization of Subcutaneous Scaffolds in Immunocompetent and Immunocompromised Mice by Smink, Alexandra M, Najdahmadi, Avid, Alexander, Michael, Li, Shiri, Rodriquez, Samuel, van Goor, Harry, Hillebrands, Jan-Luuk, Botvinick, Elliot, Lakey, Jonathan R T, Vos, Paul de

“…Islet transplantation into subcutaneous polymer scaffolds has shown to successfully induce normoglycemia in type 1 diabetes models. Vascularization of these…”
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230-LB: A Composite Capsule Strategy Support Longevity of Microencapsulated Pancreatic ß Cells by QIN, TIAN, SMINK, ALEXANDRA M., DE VOS, PAUL

“…Microencapsulation of islets in immunoprotective membranes offers an alternative treatment for type 1 diabetes in absence of systemic immunosuppression…”
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Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3 by Hu, Shuxian, Kuwabara, Rei, Beukema, Martin, Ferrari, Michela, de Haan, Bart J., Walvoort, Marthe T.C., de Vos, Paul, Smink, Alexandra M.

“…•Pectins prevent pancreatic β-cell damage during oxidative and inflammatory stress.•Pectin with lower DM value is more efficacious than higher-DM pectins in…”
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Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival by Hu, Shuxian, Kuwabara, Rei, Navarro Chica, Carlos E., Smink, Alexandra M., Koster, Taco, Medina, Juan D., de Haan, Bart J., Beukema, Martin, Lakey, Jonathan R.T., García, Andrés J., de Vos, Paul

“…Encapsulation of pancreatic islets in alginate-microcapsules is used to reduce or avoid the application of life-long immunosuppression in preventing rejection…”
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Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo by Kuwabara, Rei, Qin, Tian, Alberto Llacua, L., Hu, Shuxian, Boekschoten, Mark V, de Haan, Bart J., Smink, Alexandra M., de Vos, Paul

“…Immunoisolation of pancreatic-islets in alginate-microcapsules is applied to treat diabetes. However, long-term islet function is limited, which might be due…”
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Necrostatin‐1 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes by Smink, Alexandra M., Medina, Juan D., Haan, Bart J., García, Andrés J., Vos, Paul

“…Immunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in the absence of immunosuppression but graft survival time is still…”
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Applying Immunomodulation to Promote Longevity of Immunoisolated Pancreatic Islet Grafts by Kuwabara, Rei, Hu, Shuxian, Smink, Alexandra M, Orive, Gorka, Lakey, Jonathan R T, de Vos, Paul

“…Islet transplantation is a promising therapy for insulin-dependent diabetes, but large-scale application is hampered by the lack of a consistent source of…”
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Inclusion of extracellular matrix molecules and necrostatin-1 in the intracapsular environment of alginate-based microcapsules synergistically protects pancreatic β cells against cytokine-induced inflammatory stress by Qin, Tian, Hu, Shuxian, Smink, Alexandra M., de Haan, Bart J., Silva-Lagos, Luis A., Lakey, Jonathan R.T., de Vos, Paul

“…Immunoisolation of pancreatic islets in alginate-based microcapsules is a promising approach for grafting of islets in absence of immunosuppression. However,…”
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