Search Results - "Smiley, John"

The Thalamocortical Circuit of Auditory Mismatch Negativity by Lakatos, Peter, O’Connell, Monica N., Barczak, Annamaria, McGinnis, Tammy, Neymotin, Samuel, Schroeder, Charles E., Smiley, John F., Javitt, Daniel C.

“…Mismatch negativity (MMN) is an extensively validated biomarker of cognitive function across both normative and clinical populations and has previously been…”
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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease by Pensalfini, Anna, Kim, Seonil, Subbanna, Shivakumar, Bleiwas, Cynthia, Goulbourne, Chris N., Stavrides, Philip H., Jiang, Ying, Lee, Ju-Hyun, Darji, Sandipkumar, Pawlik, Monika, Huo, Chunfeng, Peddy, James, Berg, Martin J., Smiley, John F., Basavarajappa, Balapal S., Nixon, Ralph A.

“…Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer’s disease (AD), is mediated by the aberrant activation of Rab5 triggered…”
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Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development by Wilson, Donald A., Sullivan, Regina M., Smiley, John F., Saito, Mariko, Raineki, Charlis

“…Prenatal alcohol exposure is the leading nongenetic cause of human intellectual impairment. The long-term impacts of prenatal alcohol exposure on health and…”
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Estimates of total neuron number show that neonatal ethanol causes immediate and lasting neuron loss in cortical and subcortical areas by Smiley, John F, Bleiwas, Cynthia, Marino, Brandon M, Vaddi, Prerana, Canals-Baker, Stefanie, Wilson, Donald A, Saito, Mariko

“…In neonatal brain development there is a period of normal apoptotic cell death that regulates adult neuron number. At approximately the same period, ethanol…”
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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration by Jiang, Ying, Alam, John J., Gomperts, Stephen N., Maruff, Paul, Lemstra, Afina W., Germann, Ursula A., Stavrides, Philip H., Darji, Sandipkumar, Malampati, Sandeep, Peddy, James, Bleiwas, Cynthia, Pawlik, Monika, Pensalfini, Anna, Yang, Dun-Sheng, Subbanna, Shivakumar, Basavarajappa, Balapal S., Smiley, John F., Gardner, Amanda, Blackburn, Kelly, Chu, Hui-May, Prins, Niels D., Teunissen, Charlotte E., Harrison, John E., Scheltens, Philip, Nixon, Ralph A.

“…The endosome-associated GTPase Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a…”
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Primary Generators of Visually Evoked Field Potentials Recorded in the Macaque Auditory Cortex by Kajikawa, Yoshinao, Smiley, John F, Schroeder, Charles E

“…Prior studies have reported "local" field potential (LFP) responses to faces in the macaque auditory cortex and have suggested that such face-LFPs may be…”
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Mitonuclear mismatch alters performance and reproductive success in naturally introgressed populations of a montane leaf beetle by Rank, Nathan E., Mardulyn, Patrick, Heidl, Sarah J., Roberts, Kevin T., Zavala, Nicolas A., Smiley, John T., Dahlhoff, Elizabeth P.

“…Coordination between nuclear and mitochondrial genomes is critical to metabolic processes underlying animals’ ability to adapt to local environments, yet…”
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Microglia of Prefrontal White Matter in Suicide by Schnieder, Tatiana P, Trencevska, Iskra, Rosoklija, Gorazd, Stankov, Aleksandr, Mann, J John, Smiley, John, Dwork, Andrew J

“…ABSTRACTImmune functions in the brain are associated with psychiatric illness and temporary alteration of mental state. Microglia, the principal brain…”
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Neonatal Ethanol Disturbs the Normal Maturation of Parvalbumin Interneurons Surrounded by Subsets of Perineuronal Nets in the Cerebral Cortex: Partial Reversal by Lithium by Saito, Mariko, Smiley, John F, Hui, Maria, Masiello, Kurt, Betz, Judith, Ilina, Maria, Saito, Mitsuo, Wilson, Donald A

“…Abstract Reduction in parvalbumin-positive (PV+) interneurons is observed in adult mice exposed to ethanol at postnatal day 7 (P7), a late gestation fetal…”
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Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF by Jiang, Ying, Rigoglioso, Andrew, Peterhoff, Corrinne M, Pawlik, Monika, Sato, Yutaka, Bleiwas, Cynthia, Stavrides, Philip, Smiley, John F, Ginsberg, Stephen D, Mathews, Paul M, Levy, Efrat, Nixon, Ralph A

“…Abstract β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly implicated in Alzheimer's disease (AD) pathogenesis, although recent…”
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Cortical thickness, neuron density and size in the inferior parietal lobe in schizophrenia by Smiley, John F, Konnova, Kira, Bleiwas, Cynthia

“…Abstract The inferior parietal lobe (IPL) is a center of multisensory integration, and both functional and structural MRI studies have found evidence that…”
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Multisensory connections of monkey auditory cerebral cortex by Smiley, John F., Falchier, Arnaud

“…Functional studies have demonstrated multisensory responses in auditory cortex, even in the primary and early auditory association areas. The features of…”
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Understanding construction reform discourses by Smiley, John-Paul, Fernie, Scott, Dainty, Andrew

“…Attempts to drive change and reform of the UK construction industry have been an ongoing concern for numerous stakeholders, both in government and across…”
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Selective reduction of cerebral cortex GABA neurons in a late gestation model of fetal alcohol spectrum disorder by Smiley, John F, Saito, Mariko, Bleiwas, Cynthia, Masiello, Kurt, Ardekani, Babak, Guilfoyle, David N, Gerum, Scott, Wilson, Donald A, Vadasz, Csaba

“…Abstract Fetal alcohol spectrum disorders (FASD) are associated with cognitive and behavioral deficits, and decreased volume of the whole brain and cerebral…”
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Getting chased up the mountain: High elevation may limit performance and fitness characters in a montane insect by Dahlhoff, Elizabeth P., Dahlhoff, Victoria C., Grainger, Corrine A., Zavala, Nicolas A., Otepola‐Bello, Dami, Sargent, Brynn A., Roberts, Kevin T., Heidl, Sarah J., Smiley, John T., Rank, Nathan E., Overgaard, Johannes

“…Climate change is expected to shift species distributions as populations grow in favourable habitats and decline in harsh ones. Montane animals escape warming…”
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Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission by Cunha, Catarina, Smiley, John F., Chuhma, Nao, Shah, Relish, Bleiwas, Cynthia, Menezes, Edenia C., Seal, Rebecca P., Edwards, Robert H., Rayport, Stephen, Ansorge, Mark S., Castellanos, Francisco X., Teixeira, Catia M.

“…Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown…”
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Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome by Kaur, Gurjinder, Gauthier, Sebastien A., Perez-Gonzalez, Rocio, Pawlik, Monika, Singh, Amol Bikram, Cosby, Benjamin, Mohan, Panaiyur S., Smiley, John F., Levy, Efrat

“…Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies…”
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Effects of neonatal ethanol on cerebral cortex development through adolescence by Smiley, John F., Bleiwas, Cynthia, Masiello, Kurt, Petkova, Eva, Betz, Judith, Hui, Maria, Wilson, Donald A., Saito, Mariko

“…Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better…”
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Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer’s Disease by Zhang, Xiuli, Subbanna, Shivakumar, Williams, Colin R. O., Canals-Baker, Stefanie, Smiley, John F., Wilson, Donald A., Das, Bhaskar C., Saito, Mariko

“…BT75, a boron-containing retinoid, is a novel retinoic acid receptor (RAR)α agonist synthesized by our group. Previous studies indicated that activation of…”
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Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals by Smiley, John F., Bleiwas, Cynthia, Canals-Baker, Stefanie, Williams, Sharifa Z., Sears, Robert, Teixeira, Catia M., Wilson, Donald A., Saito, Mariko

“…In animal models that mimic human third-trimester fetal development, ethanol causes substantial cellular apoptosis in the brain, but for most brain structures,…”
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