Search Results - "Smiley, David L."

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents by Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H

“…A rationally designed peptide agonist that targets three key hormone receptors reduces obesity and its complications in a manner superior to other agonists. We…”
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Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors by Heppner, Kristy M, Piechowski, Carolin L, Müller, Anne, Ottaway, Nickki, Sisley, Stephanie, Smiley, David L, Habegger, Kirk M, Pfluger, Paul T, Dimarchi, Richard, Biebermann, Heike, Tschöp, Matthias H, Sandoval, Darleen A, Perez-Tilve, Diego

“…Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence…”
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Ghrelin‐induced adiposity is independent of orexigenic effects by Perez‐Tilve, Diego, Heppner, Kristy, Kirchner, Henriette, Lockie, Sarah H., Woods, Stephen C., Smiley, David L., Tschöp, Matthias, Pfluger, Paul

“…ABSTRACT Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive…”
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A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1 by Patterson, James T, Ottaway, Nickki, Gelfanov, Vasily M, Smiley, David L, Perez-Tilve, Diego, Pfluger, Paul T, Tschöp, Matthias H, DiMarchi, Richard D

“…Ex-4 (9-39)a is a well characterized GLP-1 receptor antagonist that suffers from two notable limitations, its nonhuman amino acid sequence and its relatively…”
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Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents by Heppner, Kristy M, Chaudhary, Nilika, Müller, Timo D, Kirchner, Henriette, Habegger, Kirk M, Ottaway, Nickki, Smiley, David L, DiMarchi, Richard, Hofmann, Susanna M, Woods, Stephen C, Sivertsen, Bjørn, Holst, Birgitte, Pfluger, Paul T, Perez-Tilve, Diego, Tschöp, Matthias H

“…Ghrelin is a gastrointestinal polypeptide that acts through the ghrelin receptor (GHSR) to promote food intake and increase adiposity. Activation of GHSR…”
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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans by Finan, Brian, Ma, Tao, Ottaway, Nickki, Müller, Timo D, Habegger, Kirk M, Heppner, Kristy M, Kirchner, Henriette, Holland, Jenna, Hembree, Jazzminn, Raver, Christine, Lockie, Sarah H, Smiley, David L, Gelfanov, Vasily, Yang, Bin, Hofmann, Susanna, Bruemmer, Dennis, Drucker, Daniel J, Pfluger, Paul T, Perez-Tilve, Diego, Gidda, Jaswant, Vignati, Louis, Zhang, Lianshan, Hauptman, Jonathan B, Lau, Michele, Brecheisen, Mathieu, Uhles, Sabine, Riboulet, William, Hainaut, Emmanuelle, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, DiMarchi, Richard D, Tschöp, Matthias H

“…We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones…”
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Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells by Kuna, Ramya S, Girada, Shravan Babu, Asalla, Suman, Vallentyne, Joyprashant, Maddika, Subbareddy, Patterson, James T, Smiley, David L, DiMarchi, Richard D, Mitra, Prasenjit

“…Glucagon-like peptide-1 receptor (GLP-1R) plays a major role in promoting glucose-stimulated insulin secretion in pancreatic β-cells. In the present study, we…”
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Ghrelin induces adiposity in rodents by Tschöp, Matthias, Smiley, David L, Heiman, Mark L

“…The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the…”
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Design and synthesis of statine-containing BACE inhibitors by JINGDAN HU, CWI, Cynthia L, MCCARTHY, James R, SMILEY, David L, TIMM, David, ERICKSON, Jon A, MCGEE, James E, YANG, Hsiu-Chiung, MENDEL, David, MAY, Patrick C, SHAPIRO, Mike

“…Utilizing structure-based techniques and solid-phase synthesis, statine-based tetrapeptide BACE inhibitors were designed and synthesized using a heptapeptide…”
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A new quorum‐sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster by Hoover, Sharon E., Perez, Amilcar J., Tsui, Ho‐Ching T., Sinha, Dhriti, Smiley, David L., DiMarchi, Richard D., Winkler, Malcolm E., Lazazzera, Beth A.

“…Summary The Phr peptides of the Bacillus species mediate quorum sensing, but their identification and function in other species of bacteria have not been…”
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Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala by Sajdyk, Tammy J, Schober, Douglas A, Smiley, David L, Gehlert, Donald R

“…The behavioral effects of direct injection of the neuropeptide Y (NPY) Y2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was…”
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A Novel and Selective β-Melanocyte-Stimulating Hormone-Derived Peptide Agonist for Melanocortin 4 Receptor Potently Decreased Food Intake and Body Weight Gain in Diet-Induced Obese Rats by Hsiung, Hansen M, Hertel, JeAnne, Zhang, Xing-yue, Smith, Dennis P, Smiley, David L, Heiman, Mark L, Yang, Derek D, Husain, Saba, Mayer, John P, Zhang, Lianshan, Mo, Huaping, Yan, Liang Zeng

“…αMSH has generally been accepted as the endogenous ligand for melanocortin 4 receptor (MC4R), which plays a major role in energy homeostasis. Targeting MC4R to…”
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Discovery of a β-MSH-Derived MC-4R Selective Agonist by Mayer, John P, Hsiung, Hansen M, Flora, David B, Edwards, Patrick, Smith, Dennis P, Zhang, Xing-Yue, Gadski, Robert A, Heiman, Mark L, Hertel, JeAnne L, Emmerson, Paul J, Husain, Saba, O'Brien, Thomas P, Kahl, Steven D, Smiley, David L, Zhang, Lianshan, DiMarchi, Richard D, Yan, Liang Zeng

“…A series of novel, disulfide-constrained human β-melanocyte stimulating hormone (β-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor…”
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Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2 by Gao, Xiaoying, Hsu, Chiun-King, Heinz, Lawrence J, Morin, John, Shi, Yuguang, Shukla, Nikhil K, Smiley, David L, Xu, Jie, Zhong, Boyu, Slieker, Lawrence J

“…We investigated the use of Eu 3+ chelate-labeled analogues of melanin-concentrating hormone (MCH) as ligands for both human MCH receptors (MCHR1 and MCHR2)…”
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Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human β-MSH(5–22) by dipeptidyl peptidase I and dipeptidyl peptidase IV by Hsiung, Hansen M., Smiley, David L., Zhang, Xing-yue, Zhang, Lianshan, Yan, Liang Zeng, Craft, Libbey, Heiman, Mark L., Smith, Dennis P.

“…Human β-MSH(1–22) was first isolated from human pituitary as a 22-amino acid (aa) peptide derived from a precursor protein, pro-opiomelanocortin (POMC)…”
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Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold by Yan, Liang Z., Flora, David, Edwards, Patrick, Smiley, David L., Emmerson, Paul J., Hsiung, Hansen M., Gadski, Robert, Hertel, JeAnne, Heiman, Mark L., Husain, Saba, O’Brien, Thomas P., Kahl, Steven D., Zhang, Lianshan, DiMarchi, Richard D., Mayer, John P.

“…Extensive structure–activity relationship studies utilizing a β-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His- d-Phe-Arg-Trp-Cys]-NH 2 ( 3), led to…”
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The neuropeptide Y Y1 antagonist, 1229U91, a potent agonist for the human pancreatic polypeptide-preferring (NPY Y4) receptor by Schober, D A, Van Abbema, A M, Smiley, D L, Bruns, R F, Gehlert, D R

“…Recently, a novel high-affinity peptide antagonist, 1229U91, was published as a selective neuropeptide Y Y1 antagonist. The selectivity of 1229U91 was…”
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Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution by Jin, L, Briggs, S L, Chandrasekhar, S, Chirgadze, N Y, Clawson, D K, Schevitz, R W, Smiley, D L, Tashjian, A H, Zhang, F

“…The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH…”
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A new quorum‐sensing system ( TprA / PhrA ) for S treptococcus pneumoniae   D 39 that regulates a lantibiotic biosynthesis gene cluster by Hoover, Sharon E., Perez, Amilcar J., Tsui, Ho‐Ching T., Sinha, Dhriti, Smiley, David L., DiMarchi, Richard D., Winkler, Malcolm E., Lazazzera, Beth A.

“…Summary The Phr peptides of the B acillus species mediate quorum sensing, but their identification and function in other species of bacteria have not been…”
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Neuropeptide Y-Y 2 receptors mediate anxiety in the amygdala by Sajdyk, Tammy J., Schober, Douglas A., Smiley, David L., Gehlert, Donald R.

“…The behavioral effects of direct injection of the neuropeptide Y (NPY) Y 2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was…”
Get full text