Redisplacement of reduced distal radius fractures in adults: does the type of casting play a role? The CAST study, a multicentre cluster randomized controlled trial

Redisplacement of reduced distal radius fractures in adults: does the type of casting play a role? The CAST study, a multicentre cluster randomized controlled trial

It is not clear which type of casting provides the best initial treatment in adults with a distal radial fracture. Given that between 32% and 64% of adequately reduced fractures redisplace during immobilization in a cast, preventing redisplacement and a disabling malunion or secondary surgery is an...

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Bibliographic Details
Published in:The bone & joint journal Vol. 106-B; no. 7; p. 696
Main Authors: Barvelink, Britt, Reijman, Max, Smidt, Sanne, Miranda Afonso, Pedro, Verhaar, Jan A N, Colaris, Joost W, van Beek, Flip, Bouwhuis, Marna G, Bruijninckx, Milko M M, Greeven, Alexander P A, Gosens, Taco, Kok, Mirte J, Kokke, Marike C, Kraan, Gerald A, van Lakwijk, Kevin, Leijnen, Michiel, van Loon, Merel, van Rijssel, Daphne A, Schep, Niels W L, Scholtens, Lenneke, Wijffels, Mathieu M E, Slebioda, Ninka, van der Zwaal, Peer, Zwets, Egon
Format: Journal Article
Language:English
Published: England 01-07-2024
Subjects:
Adult
Aged
Casts, Surgical
Female
Humans
Male
Middle Aged
Patient Reported Outcome Measures
Radius Fractures - therapy
Splints
Treatment Outcome
Wrist Fractures
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Summary:It is not clear which type of casting provides the best initial treatment in adults with a distal radial fracture. Given that between 32% and 64% of adequately reduced fractures redisplace during immobilization in a cast, preventing redisplacement and a disabling malunion or secondary surgery is an aim of treatment. In this study, we investigated whether circumferential casting leads to fewer the redisplacement of fewer fractures and better one-year outcomes compared with plaster splinting. In a pragmatic, open-label, multicentre, two-period cluster-randomized superiority trial, we compared these two types of casting. Recruitment took place in ten hospitals. Eligible patients aged ≥ 18 years with a displaced distal radial fracture, which was acceptably aligned after closed reduction, were included. The primary outcome measure was the rate of redisplacement within five weeks of immobilization. Secondary outcomes were the rate of complaints relating to the cast, clinical outcomes at three months, patient-reported outcome measures (PROMs) (using the numerical rating scale (NRS), the abbreviated version of the Disabilities of the Arm, Shoulder and Hand (QuickDASH), and Patient-Rated Wrist/Hand Evaluation (PRWHE) scores), and adverse events such as the development of compartment syndrome during one year of follow-up. We used multivariable mixed-effects logistic regression for the analysis of the primary outcome measure. The study included 420 patients. There was no significant difference between the rate of redisplacement of the fracture between the groups: 47% (n = 88) for those treated with a plaster splint and 49% (n = 90) for those treated with a circumferential cast (odds ratio 1.05 (95% confidence interval (CI) 0.65 to 1.70); p = 0.854). Patients treated in a plaster splint reported significantly more pain than those treated with a circumferential cast, during the first week of treatment (estimated mean NRS 4.7 (95% CI 4.3 to 5.1) vs 4.1 (95% CI 3.7 to 4.4); p = 0.014). The rate of complaints relating to the cast, clinical outcomes and PROMs did not differ significantly between the groups (p > 0.05). Compartment syndrome did not occur. Circumferential casting did not result in a significantly different rate of redisplacement of the fracture compared with the use of a plaster splint. There were comparable outcomes in both groups.
ISSN:2049-4408
DOI:10.1302/0301-620X.106B7.BJJ-2024-0014.R1