Search Results - "Smibert, Craig A."

An eIF4E1/4E-T Complex Determines the Genesis of Neurons from Precursors by Translationally Repressing a Proneurogenic Transcription Program by Yang, Guang, Smibert, Craig A., Kaplan, David R., Miller, Freda D.

“…Here, we have addressed the mechanisms that determine genesis of the correct numbers of neurons during development, focusing on the embryonic cortex. We…”
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Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors by Chen, Yung-Chia Ariel, Stuwe, Evelyn, Luo, Yicheng, Ninova, Maria, Le Thomas, Adrien, Rozhavskaya, Ekaterina, Li, Sisi, Vempati, Sivani, Laver, John D., Patel, Dinshaw J., Smibert, Craig A., Lipshitz, Howard D., Fejes Toth, Katalin, Aravin, Alexei A.

“…Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system that represses transposable elements in germ cells of Metazoa. In Drosophila…”
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RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes by Shen, Qingtang, Wang, Yifan E, Truong, Mathew, Mahadevan, Kohila, Wu, Jingze J, Zhang, Hui, Li, Jiawei, Smith, Harrison W, Smibert, Craig A, Palazzo, Alexander F

“…Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the…”
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Chemical entrapment and killing of insects by bacteria by Ho, Louis K., Daniel-Ivad, Martin, Jeedigunta, Swathi P., Li, Jing, Iliadi, Konstantin G., Boulianne, Gabrielle L., Hurd, Thomas R., Smibert, Craig A., Nodwell, Justin R.

“…Actinobacteria produce antibacterial and antifungal specialized metabolites. Many insects harbour actinobacteria on their bodies or in their nests and use…”
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The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes by Rissland, Olivia S, Subtelny, Alexander O, Wang, Miranda, Lugowski, Andrew, Nicholson, Beth, Laver, John D, Sidhu, Sachdev S, Smibert, Craig A, Lipshitz, Howard D, Bartel, David P

“…All mRNAs are bound in vivo by proteins to form mRNA-protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation…”
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Regulation and Function of Maternal Gene Products During the Maternal-to-Zygotic Transition in Drosophila by Laver, John D, Marsolais, Alexander J, Smibert, Craig A, Lipshitz, Howard D

“…Drosophila late-stage oocytes and early embryos are transcriptionally silent. Thus, control of gene expression during these developmental periods is…”
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Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition by Cao, Wen Xi, Kabelitz, Sarah, Gupta, Meera, Yeung, Eyan, Lin, Sichun, Rammelt, Christiane, Ihling, Christian, Pekovic, Filip, Low, Timothy C.H., Siddiqui, Najeeb U., Cheng, Matthew H.K., Angers, Stephane, Smibert, Craig A., Wühr, Martin, Wahle, Elmar, Lipshitz, Howard D.

“…In animal embryos, the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal…”
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Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte by Mohr, Sabine, Kenny, Andrew, Lam, Simon T Y, Morgan, Miles B, Smibert, Craig A, Lipshitz, Howard D, Macdonald, Paul M

“…Localization of oskar mRNA includes two distinct phases: transport from nurse cells to the oocyte, a process typically accompanied by cortical anchoring in the…”
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The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs by Laver, John D., Ly, Jimmy, Winn, Jamie K., Karaiskakis, Angelo, Lin, Sichun, Nie, Kun, Benic, Giulia, Jaberi-Lashkari, Nima, Cao, Wen Xi, Khademi, Alireza, Westwood, J. Timothy, Sidhu, Sachdev S., Morris, Quaid, Angers, Stephane, Smibert, Craig A., Lipshitz, Howard D.

“…G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed…”
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A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis by Amadei, Gianluca, Zander, Mark A, Yang, Guang, Dumelie, Jason G, Vessey, John P, Lipshitz, Howard D, Smibert, Craig A, Kaplan, David R, Miller, Freda D

“…Here, we have asked about post-transcriptional mechanisms regulating murine developmental neurogenesis, focusing upon the RNA-binding proteins Smaug2 and…”
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ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition by Wang, Miranda, Ly, Michael, Lugowski, Andrew, Laver, John D, Lipshitz, Howard D, Smibert, Craig A, Rissland, Olivia S

“…In animal embryos, control of development is passed from exclusively maternal gene products to those encoded by the embryonic genome in a process referred to…”
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SMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila and Its Translation Is Activated by the PAN GU Kinase by Tadros, Wael, Goldman, Aaron L., Babak, Tomas, Menzies, Fiona, Vardy, Leah, Orr-Weaver, Terry, Hughes, Timothy R., Westwood, J. Timothy, Smibert, Craig A., Lipshitz, Howard D.

“…In animals, egg activation triggers a cascade of posttranscriptional events that act on maternally synthesized RNAs. We show that, in Drosophila, the PAN GU…”
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An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition by Benoit, Beatrice, He, Chun Hua, Zhang, Fan, Votruba, Sarah M, Tadros, Wael, Westwood, J Timothy, Smibert, Craig A, Lipshitz, Howard D, Theurkauf, William E

“…Genetic control of embryogenesis switches from the maternal to the zygotic genome during the maternal-to-zygotic transition (MZT), when maternal mRNAs are…”
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The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators by Sicheri, Frank, Smibert, Craig A, Aviv, Tzvi, Lin, Zhen, Lau, Stefanie, Rendl, Laura M

“…Anteroposterior patterning in Drosophila melanogaster is dependent on the sequence-specific RNA-binding protein Smaug, which binds to and regulates the…”
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Drosophila Maternal Hsp83 mRNA Destabilization Is Directed by Multiple SMAUG Recognition Elements in the Open Reading Frame by Semotok, Jennifer L., Luo, Hua, Cooperstock, Ramona L., Karaiskakis, Angelo, Vari, Heli K., Smibert, Craig A., Lipshitz, Howard D.

“…ERRATUM ( vol. 28 , p. 7533 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay by Rendl, Laura M, Bieman, Melissa A, Vari, Heli K, Smibert, Craig A

“…Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization…”
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Mechanisms of RNA localization and translational regulation by Lipshitz, Howard D, Smibert, Craig A

“…Transcript localization and translational regulation are two post-transcriptional mechanisms for the spatial and temporal regulation of protein production…”
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Synthetic antibodies as tools to probe RNA-binding protein function by Laver, John D, Ancevicius, Kristin, Sollazzo, Pietro, Westwood, J Timothy, Sidhu, Sachdev S, Lipshitz, Howard D, Smibert, Craig A

“…RNA-binding proteins (RBPs) have essential roles in post-transcriptional regulation of gene expression. They bind sequence elements in specific mRNAs and…”
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A Multiprotein Complex That Mediates Translational Enhancement in Drosophila by Nelson, Meryl R., Luo, Hua, Vari, Heli K., Cox, Brian J., Simmonds, Andrew J., Krause, Henry M., Lipshitz, Howard D., Smibert, Craig A.

“…Modulating the efficiency of translation plays an important role in a wide variety of cellular processes and is often mediated by trans-acting factors that…”
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microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein by Pinder, Benjamin D, Smibert, Craig A

“…Argonaute (Ago) proteins are typically recruited to target messenger RNAs via an associated small RNA such as a microRNA (miRNA). Here, we describe a new…”
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