Search Results - "Smeyne, Richard J."

Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo by Kozina, Elena, Sadasivan, Shankar, Jiao, Yun, Dou, Yuchen, Ma, Zhijun, Tan, Haiyan, Kodali, Kiran, Shaw, Timothy, Peng, Junmin, Smeyne, Richard J

“…Mutations in LRRK2 are the most common cause of familial Parkinson's disease, but display incomplete penetrance in humans and in mouse models. Kozina et al…”
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In memorium, Michael Zigmond, PhD by Smeyne, Richard J.

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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte by Chen, Pei-Chun, Vargas, Marcelo R, Pani, Amar K, Smeyne, Richard J, Johnson, Delinda A, Kan, Yuet Wai, Johnson, Jeffrey A

“…Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of…”
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Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice by Rocha, Savannah M., Bantle, Collin M., Aboellail, Tawfik, Chatterjee, Debotri, Smeyne, Richard J., Tjalkens, Ronald B.

“…Rotenone is a naturally occurring insecticide that inhibits mitochondrial complex I and leads to neurochemical and neuropathological deficits closely…”
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Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus by Sadasivan, Shankar, Zanin, Mark, O'Brien, Kevin, Schultz-Cherry, Stacey, Smeyne, Richard J

“…Although influenza is primarily a respiratory disease, it has been shown, in some cases, to induce encephalitis, including people acutely infected with the…”
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Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration by Jang, Haeman, Boltz, David, Sturm-Ramirez, Katharine, Shepherd, Kennie R, Jiao, Yun, Webster, Robert, Smeyne, Richard J

“…One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of the 433 known human…”
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Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models by Chun, Sungkun, Westmoreland, Joby J., Bayazitov, Ildar T., Eddins, Donnie, Pani, Amar K., Smeyne, Richard J., Yu, Jing, Blundon, Jay A., Zakharenko, Stanislav S.

“…Auditory hallucinations in schizophrenia are alleviated by antipsychotic agents that inhibit D2 dopamine receptors (Drd2s). The defective neural circuits and…”
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Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier by Muldoon, Leslie L, Alvarez, Jorge I, Begley, David J, Boado, Ruben J, del Zoppo, Gregory J, Doolittle, Nancy D, Engelhardt, Britta, Hallenbeck, John M, Lonser, Russell R, Ohlfest, John R, Prat, Alexandre, Scarpa, Maurizio, Smeyne, Richard J, Drewes, Lester R, Neuwelt, Edward A

“…The brain is in many ways an immunologically and pharmacologically privileged site. The blood–brain barrier (BBB) of the cerebrovascular endothelium and its…”
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Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice by Sadasivan, Shankar, Pond, Brooks B, Pani, Amar K, Qu, Chunxu, Jiao, Yun, Smeyne, Richard J

“…Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the…”
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Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus by Bantle, Collin M, French, C Tenley, Cummings, Jason E, Sadasivan, Shankar, Tran, Kevin, Slayden, Richard A, Smeyne, Richard J, Tjalkens, Ronald B

“…Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration…”
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Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice by Heyer, Mary P, Pani, Amar K, Smeyne, Richard J, Kenny, Paul J, Feng, Guoping

“…Midbrain dopaminergic (mDA) neurons control movement and emotion, and their degeneration leads to motor and cognitive defects in Parkinson's disease (PD)…”
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Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling by Blundon, Jay A., Roy, Noah C., Teubner, Brett J. W., Yu, Jing, Eom, Tae-Yeon, Sample, K. Jake, Pani, Amar, Smeyne, Richard J., Han, Seung Baek, Kerekes, Ryan A., Rose, Derek C., Hackett, Troy A., Vuppala, Pradeep K., Freeman, Burgess B., Zakharenko, Stanislav S.

“…Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively…”
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GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults by Cheslow, Lara, Byrne, Matthew, Kopenhaver, Jessica S., Iacovitti, Lorraine, Smeyne, Richard J., Snook, Adam E., Waldman, Scott A.

“…Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the substantia nigra pars compacta (SNpc) are central drivers of dopaminergic…”
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Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta by Jiao, Yun, Lu, Lu, Williams, Robert W, Smeyne, Richard J

“…The etiology of the vast majority of Parkinson's disease (PD) cases is unknown. It is generally accepted that there is an interaction between exposures to…”
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Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice by Pani, Amar K, Jiao, Yun, Sample, Kenneth J, Smeyne, Richard J

“…Adenosine (ADO), a non-classical neurotransmitter and neuromodulator, and its metabolites adenosine triphosphate (ATP), adenosine diphosphate (ADP) and…”
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Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior by Humann, Jessica, Mann, Beth, Gao, Geli, Moresco, Philip, Ramahi, Joseph, Loh, Lip Nam, Farr, Arden, Hu, Yunming, Durick-Eder, Kelly, Fillon, Sophie A., Smeyne, Richard J., Tuomanen, Elaine I.

“…Maternal infection during pregnancy is associated with adverse outcomes for the fetus, including postnatal cognitive disorders. However, the underlying…”
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Exercise: Is it a neuroprotective and if so, how does it work? by Zigmond, Michael J, Smeyne, Richard J

“…Summary There is clinical evidence that the symptoms of Parkinson's disease can be ameliorated by physical exercise, and we have been using animal models to…”
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Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons by Wei, Peng, Smeyne, Richard J., Bao, Dashi, Parris, Jennifer, Morgan, James I.

“…Cbln1 is a secreted glycoprotein essential for synapse structure and function in cerebellum that is also expressed in extracerebellar structures where its…”
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Glia cell number modulates sensitivity to MPTP in mice by Smeyne, Michelle, Jiao, Yun, Shepherd, Kennie R., Smeyne, Richard J.

“…Free radical damage has been shown to play a significant role in the pathogenesis of a number of neurodegenerative diseases including Parkinson's disease. One…”
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COVID‐19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism by Smeyne, Richard J., Eells, Jeffrey B., Chatterjee, Debotri, Byrne, Matthew, Akula, Shaw M., Sriramula, Srinivas, O'Rourke, Dorcas P., Schmidt, Peter

“…ABSTRACT Background Viral induction of neurological syndromes has been a concern since parkinsonian‐like features were observed in patients diagnosed with…”
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