Search Results - "Smethurst, P"

A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder by HERMANS, C., WITTEVRONGEL, C., THYS, C., SMETHURST, P. A., VAN GEET, C., FRESON, K.

“…Background: The physiological relevance of the collagen glycoprotein VI (GPVI) receptor was known prior to its recognition as a platelet membrane receptor as…”
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Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain by Basu, B., Correa de Sampaio, P., Mohammed, H., Fogarasi, M., Corrie, P., Watkins, N.A., Smethurst, P.A., English, W.R., Ouwehand, W.H., Murphy, G.

“…The membrane associated MMP, MT1-MMP, is a critical pericellular protease involved in tumour cell invasion and angiogenesis and is highly up-regulated in…”
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Defining the relation between soil water content and net nitrogen mineralization by Paul, K.I, Polglase, P.J, O'Connell, A.M, Carlyle, J.C, Smethurst, P.J, Khanna, P.K

“…Summary Simulation models of net mineralization of nitrogen (N) in soil need to be able to incorporate the effect of soil water. Our objective was to identify…”
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Growth responses of Eucalyptus globulus Labill. to nitrogen application and severity, pattern and frequency of artificial defoliation by Pinkard, E.A., Baillie, C.C., Patel, V., Paterson, S., Battaglia, M., Smethurst, P.J., Mohammed, C.L., Wardlaw, T., Stone, C.

“…Defoliation from herbivores can reduce growth of affected plants, and this has been demonstrated for plantation-grown Eucalyptus globulus. We undertook a field…”
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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma by Linette, Gerald P., Stadtmauer, Edward A., Maus, Marcela V., Rapoport, Aaron P., Levine, Bruce L., Emery, Lyndsey, Litzky, Leslie, Bagg, Adam, Carreno, Beatriz M., Cimino, Patrick J., Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Gerry, Andrew B., Pumphrey, Nick J., Bennett, Alan D., Brewer, Joanna E., Dukes, Joseph, Harper, Jane, Tayton-Martin, Helen K., Jakobsen, Bent K., Hassan, Namir J., Kalos, Michael, June, Carl H.

“…An obstacle to cancer immunotherapy has been that the affinity of T-cell receptors (TCRs) for antigens expressed in tumors is generally low. We initiated…”
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Role of light fraction soil organic matter in the phosphorus nutrition of Eucalyptus globulus seedlings by O'Hara, C.P., Bauhus, J., Smethurst, P.J.

“…Different fractions of soil organic matter (SOM) may contribute to varying degrees to phosphorus (P) recycling and supply. This study investigated the…”
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Gain‐ and loss‐of‐function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen by O'CONNOR, M. N., SMETHURST, P. A., FARNDALE, R. W., OUWEHAND, W. H.

“…Background: By site‐directed mutagenesis of recombinant receptor fragments, we have previously identified residue lysine59 of the platelet collagen receptor…”
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Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in‐depth exon resequencing and genotyping with tag single nucleotide polymorphisms by WATKINS, N. A., O'CONNOR, M. N., RANKIN, A., JENNINGS, N., WILSON, E., HARMER, I. J., DAVIES, L., SMETHURST, P. A., DUDBRIDGE, F., FARNDALE, R. W., OUWEHAND, W. H.

“…Background: Common genetic variants of cell surface receptors contribute to differences in functional responses and disease susceptibility. We have previously…”
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Surface soil changes in base cation concentrations in fertilised hardwood and softwood plantations in Australia by Mitchell, A.D, Smethurst, P.J

“…Soils at seven nitrogen (N) and phosphorus (P) fertiliser experiments in Australia were sampled to determine the changes in exchangeable and soil solution…”
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The impact of timing and duration of grass control on growth of a young Eucalyptus globulus Labill. plantation by ADAMS, P. R, BEADLE, C. L, MENDHAM, N. J, SMETHURST, P. J

“…Interference by an introduced grass, Holcus lanatus L. (Yorkshire fog grass) in a young E. globulus (Tasmanian blue gum) plantation was investigated. The…”
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Soil temperature under forests: a simple model for predicting soil temperature under a range of forest types by Paul, Keryn I, Polglase, Philip J, Smethurst, Philip J, O’Connell, Anthony M, Carlyle, Clive J, Khanna, Partap K

“…A new model (soil temperature under forests—STUF) is described for predicting the seasonal variation of daily average temperature within surface soil layers…”
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Soil water under forests (SWUF): a model of water flow and soil water content under a range of forest types by Paul, K.I., Polglase, P.J., O’Connell, A.M., Carlyle, J.C., Smethurst, P.J., Khanna, P.K., Worledge, D.

“…A new model (soil water under forest, SWUF) is suitable for predicting the daily water content within both surface soil layers and the sub-soil under a range…”
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Soil solution and other soil analyses as indicators of nutrient supply: a review by Smethurst, Philip J

“…This review examines the potential for using soil solution as a tool for managing soil fertility. A review of the current use of other types of soil analyses…”
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Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy by Bjarnason, I, Hayllar, J, Smethurst, P, Price, A, Gumpel, M J

“…This study assessed the effect of metronidazole on the gastroduodenal mucosa, intestinal permeability, blood loss, and inflammation in patients on…”
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Power laws Are hospital waiting lists self-regulating? by Smethurst, D. P, Williams, H. C

“…We have discovered that waiting lists to see hospital consultants are subject to the power laws of complexity theory, and so are likely to be an essential…”
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First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: A Phase I/II open-label and double-blind study by Demetri, George D, Le Cesne, Axel, Chawla, Sant P, Brodowicz, Thomas, Maki, Robert G, Bach, Bruce A, Smethurst, Dominic P, Bray, Sarah, Hei, Yong-jiang, Blay, Jean-Yves

“…Abstract Background Conatumumab is a fully human monoclonal agonist antibody that binds to death receptor 5 and induces apoptosis in sensitive cells. This…”
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Soil supply and nutrient demand (SSAND): A general nutrient uptake model and an example of its application to forest management by Comerford, N.B, Cropper, W.P. Jr, Li, H, Smethurst, P.J, Van Rees, K.C.J, Jokela, E.J, Adegbidi, H, Barros, N.F

“…Models of soil nutrient bioavailability and uptake assist in nutrient management and lead to a better understanding of nutrient dynamics in the soil-plant…”
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Characteristics of tree seedlings and neighbouring vegetation have an additive influence on browsing by generalist herbivores by Miller, Alison M., McArthur, Clare, Smethurst, Philip J.

“…Browsing of commercial tree seedlings by mammalian herbivores can reduce long-term plantation productivity, and is an economic problem worldwide…”
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Fertilization Effects on Soil Solution Chemistry in Three Eucalypt Plantations by Smethurst, P.J., Herbert, A.M., Ballard, L.M.

“…Concentrations of nutrients in soil solution may by important indicators of nutrient availability for forest plantations, but we were unaware of the extent to…”
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Review: Prion-like mechanisms of transactive response DNA binding protein of 43kDa (TDP-43) in amyotrophic lateral sclerosis (ALS) by Smethurst, Phillip, Sidle, Katie Claire Louise, Hardy, John

“…Amyotrophic lateral sclerosis (ALS) is a fatal devastating neurodegenerative disorder which predominantly affects the motor neurons in the brain and spinal…”
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