Search Results - "Smeets, Serge"

Application of systems biology-based in silico tools to optimize treatment strategy identification in Still's disease by Segú-Vergés, Cristina, Coma, Mireia, Kessel, Christoph, Smeets, Serge, Foell, Dirk, Aldea, Anna

“…Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are manifestations of an autoinflammatory disorder with complex…”
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A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen by Smeets, Serge J., Hesselink, Albertus T., Speel, Ernst‐Jan M., Haesevoets, Annick, Snijders, Peter J.F., Pawlita, Michael, Meijer, Chris J.L.M., Braakhuis, Boudewijn J.M., Leemans, C. René, Brakenhoff, Ruud H.

“…Human papillomavirus type 16 (HPV16) plays a role in the development of a subgroup of head and neck squamous cell carcinomas (HNSCC). However, uncertainty…”
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Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways by Smeets, Serge J., van der Plas, Marlon, Schaaij‐Visser, Tieneke B.M., van Veen, Eva A.M., van Meerloo, Johan, Braakhuis, Boudewijn J.M., Steenbergen, Renske D.M., Brakenhoff, Ruud H.

“…A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high‐risk human papillomavirus‐type 16 (HPV16). The viral E6 and E7 oncoproteins…”
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Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors by Franke, Niels E, Kaspers, Gertjan L, Assaraf, Yehuda G, van Meerloo, Johan, Niewerth, Denise, Kessler, Floortje L, Poddighe, Pino J, Kole, Jeroen, Smeets, Serge J, Ylstra, Bauke, Bi, Chonglei, Chng, Wee Joo, Horton, Terzah M, Menezes, Rene X, Musters, Renée J P, Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline

“…PSMB5 mutations and upregulation of the β5 subunit of the proteasome represent key determinants of acquired resistance to the proteasome inhibitor bortezomib…”
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Intensity-based analysis of dual-color gene expression data as an alternative to ratio-based analysis to enhance reproducibility by Bossers, Koen, Ylstra, Bauke, Brakenhoff, Ruud H, Smeets, Serge J, Verhaagen, Joost, van de Wiel, Mark A

“…Ratio-based analysis is the current standard for the analysis of dual-color microarray data. Indeed, this method provides a powerful means to account for…”
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CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material by Krijgsman, Oscar, Israeli, Danielle, Haan, Josien C., van Essen, Hendrik F., Smeets, Serge J., Eijk, Paul P., M. Steenbergen, Renske D., Kok, Klaas, Tejpar, Sabine, Meijer, Gerrit A., Ylstra, Bauke

“…Formalin‐fixed, paraffin‐embedded (FFPE) archival tissue is an important source of DNA material. The most commonly used technique to identify copy number…”
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To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic by SMEETS, Serge J, HARJES, Ulrike, VAN WIERINGEN, Wessel N, SIE, Daoud, BRAKENHOFF, Ruud H, MEIJER, Gerrit A, YLSTRA, Bauke

“…Genome-wide RNA expression profiling has yielded tumor subtypes with strong predictive or prognostic value for a wide variety of cancers. Recently, for breast…”
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Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck by Wilting, Saskia M, Smeets, Serge J, Snijders, Peter J F, van Wieringen, Wessel N, van de Wiel, Mark A, Meijer, Gerrit A, Ylstra, Bauke, Leemans, C René, Meijer, Chris J L M, Brakenhoff, Ruud H, Braakhuis, Boudewijn J M, Steenbergen, Renske D M

“…It is well known that a persistent infection with high-risk human papillomavirus (hrHPV) is causally involved in the development of squamous cell carcinomas of…”
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Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential by Zafrakas, Menelaos, Tarlatzis, Basil, Streichert, Thomas, Pournaropoulos, Fotios, Wölfle, Ute, Smeets, Serge, Wittek, Britta, Grimbizis, Grigorios, Brakenhoff, Ruud, Pantel, Klaus, Bontis, John, Günes, Cagatay

“…The aim of the present study was to investigate whether endometriosis and cancer share common molecular characteristics. Tissue samples were collected…”
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Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis by Smeets, Serge J, Brakenhoff, Ruud H, Ylstra, Bauke, van Wieringen, Wessel N, van de Wiel, Mark A, Leemans, C René, Braakhuis, Boudewijn J M

“…The common risk factors for oral and oropharyngeal cancer are tobacco smoking and alcohol consumption, and recently the human papillomavirus (HPV) was shown to…”
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Characterization of the human Ly‐6 antigens, the newly annotated member Ly‐6K included, as molecular markers for head‐and‐neck squamous cell carcinoma by de Nooij‐van Dalen, Arnolda G., van Dongen, Guus A.M.S., Smeets, Serge J., Nieuwenhuis, Eline J.C., Stigter‐van Walsum, Marijke, Snow, Gordon B., Brakenhoff, Ruud H.

“…The E48 antigen is a successfully explored molecular marker for the diagnosis and therapy of HNSCC. The applicability of E48 as an HNSCC‐associated antigen,…”
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CGHMultiArray: exact P-values for multi-array comparative genomic hybridization data by van de Wiel, Mark A., Smeets, Serge J., Brakenhoff, Ruud H., Ylstra, Bauke

“…We compute P-values, based on the Wilcoxon test with ties, to compare two conditions with array comparative genomic hybridization data, and we provide a simple…”
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Identification of genes putatively involved in the pathogenesis of diffuse large B-cell lymphomas by integrative genomics by Oudejans, Joost J., van Wieringen, Wessel N., Smeets, Serge J., Tijssen, Marianne, Vosse, Sjoerd J., Meijer, Chris J. L. M., Meijer, Gerrit A., van de Wiel, Mark A., Ylstra, Bauke

“…Diffuse large B‐cell lymphomas (DLBCL) are highly heterogeneous with regard to clinical presentation and outcome. DLBCL copy number aberrations have been…”
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DNA quality assessment for array CGH by isothermal whole genome amplification by Buffart, Tineke E, Tijssen, Marianne, Krugers, Thijs, Carvalho, Beatriz, Smeets, Serge J, Brakenhoff, Ruud H, Grabsch, Heike, Meijer, Gerrit A, Sadowski, Henry B, Ylstra, Bauke

“…Array Comparative Genomic Hybridization (array CGH) is increasingly applied on DNA obtained from formalin-fixed paraffin-embedded (FFPE) tissue, but in a…”
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Comparative proteome analysis to explore p53 pathway disruption in head and neck carcinogenesis by Schaaij-Visser, Tieneke B.M., Brakenhoff, Ruud H., Jansen, Jeroen W.A., O’Flaherty, Martina C., Smeets, Serge J., Heck, Albert J.R., Slijper, Monique

“…The 5-year-survival rate of head and neck squamous cell carcinoma (HNSCC) has been only moderately improved over the last few decades. HNSCC develops in…”
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Treatment of IgA Nephropathy in Chinese Patients: Evidence from Real-World Data: SA-PO900 by Wang, Weiming, Li, Runqin, Li, Ping, Gao, Fei, Smeets, Serge, George, Aneesh T., de Courcy, Jonathan

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5424 SYMPTOM CONTROL WITH CURRENTLY AVAILABLE IMMUNOGLOBULIN A NEPHROPATHY TREATMENT: RESULTS FROM A REAL-WORLD SURVEY IN EIGHT COUNTRIES by Chen, Wei, Smeets, Serge, Prieto, Luis, Kroes, Michel, George, Aneesh Thomas, Decourcy, Jonathan, Garratt-Wheeldon, Jade

“…Abstract Background and Aims Immunoglobulin A nephropathy (IgAN) is the most prevalent form of primary glomerulonephritis worldwide with an estimated annual…”
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5392 THE DIAGNOSTIC JOURNEY OF PATIENTS WITH IMMUNOGLOBULIN A NEPHROPATHY: DATA ANALYSIS OF A REAL-WORLD SURVEY by Kroes, Michel, Smeets, Serge, George, Aneesh Thomas, Prieto, Luis, Decourcy, Jonathan, Garratt-Wheeldon, Jade

“…Abstract Background and Aims Although rare (estimated global annual incidence of 25 cases per million people), immunoglobulin A nephropathy (IgAN) is the most…”
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Persistence of Signs and Symptoms in Treated Patients with C3 Glomerulopathy (C3G): Evidence from Real-World Data: TH-PO646 by Lafayette, Richard A., Libby, Susanna, Pannagl, Katharina, Ndife, Briana C., Smeets, Serge, Murphy, Kathleen, de Courcy, Jonathan, Proudfoot, Clare

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Real-World Time to Diagnosis in C3 Glomerulopathy (C3G): TH-PO647 by Lafayette, Richard A., Pannagl, Katharina, Ndife, Briana C., Smeets, Serge, Murphy, Kathleen, de Courcy, Jonathan, Libby, Susanna, Proudfoot, Clare

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