Search Results - "Smee, Penny A."

p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression by Aston, Nicola M, Bamborough, Paul, Buckton, Jacqueline B, Edwards, Christopher D, Holmes, Duncan S, Jones, Katherine L, Patel, Vipulkumar K, Smee, Penny A, Somers, Donald O, Vitulli, Giovanni, Walker, Ann L

“…p38α MAP kinase is a key anti-inflammatory target for rheumatoid arthritis, influencing biosynthesis of pro-inflammatory cytokines TNFα and IL-1β at a…”
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Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity by Angell, Richard, Aston, Nicola M., Bamborough, Paul, Buckton, Jacky B., Cockerill, Stuart, deBoeck, Suzanne J., Edwards, Chris D., Holmes, Duncan S., Jones, Katherine L., Laine, Dramane I., Patel, Shila, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L.

“…The biphenyl amides (BPAs) are a novel series of p38α MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an vivo disease…”
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Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes by Angell, Richard M., Angell, Tony D., Bamborough, Paul, Bamford, Mark J., Chung, Chun-wa, Cockerill, Stuart G., Flack, Stephen S., Jones, Katherine L., Laine, Dramane I., Longstaff, Timothy, Ludbrook, Steve, Pearson, Rosannah, Smith, Kathryn J., Smee, Penny A., Somers, Don O., Walker, Ann L.

“…The biphenyl amides (BPAs) are a series of p38α MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation,…”
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Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR by Angell, Richard M., Angell, Tony D., Bamborough, Paul, Brown, David, Brown, Murray, Buckton, Jacky B., Cockerill, Stuart G., Edwards, Chris D., Jones, Katherine L., Longstaff, Tim, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L., Willson, Malcolm

“…Structure–activity relationships of the biphenyl amide (BPA) series against p38α are discussed with reference to the X-ray crystal structure of an example. The…”
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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility by Douthwaite, Julie A., Brown, Christopher A., Ferdinand, John R., Sharma, Rahul, Elliott, Jane, Taylor, Molly A., Malintan, Nancy T., Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L., Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J., Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K., DeWildt, Ruud M., Weaver, Shane, Smee, Penny A., van Kempen, Joost, Bartlett, Jon G., Allen, Paula M., Koppe, Emma L., Ashby, Charlotte A., Phipps, Julian D., Mehta, Nalini, Brierley, David J., Tew, David G., Leveridge, Melanie V., Baddeley, Stuart M., Goodfellow, Ian G., Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H., Pangalos, Menelas N., Howes, Rob, Clark, Roger

“…On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of…”
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p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression by Aston, Nicola M, Bamborough, Paul, Buckton, Jacqueline B, Edwards, Christopher D, Holmes, Duncan S, Jones, Katherine L, Patel, Vipulkumar K, Smee, Penny A, Somers, Donald O, Vitulli, Giovanni, Walker, Ann L

“…p38alpha MAP kinase is a key anti-inflammatory target for rheumatoid arthritis, influencing biosynthesis of pro-inflammatory cytokines TNFalpha and IL-1beta at…”
Get full text