Search Results - "Smeds, Johanna"

Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis by Sotiriou, Christos, Wirapati, Pratyaksha, Loi, Sherene, Harris, Adrian, Fox, Steve, Smeds, Johanna, Nordgren, Hans, Farmer, Pierre, Praz, Viviane, Haibe-Kains, Benjamin, Desmedt, Christine, Larsimont, Denis, Cardoso, Fatima, Peterse, Hans, Nuyten, Dimitry, Buyse, Marc, Van de Vijver, Marc J., Bergh, Jonas, Piccart, Martine, Delorenzi, Mauro

“…Background: Histologic grade in breast cancer provides clinically important prognostic information. However, 30%–60% of tumors are classified as histologic…”
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An Expression Signature for p53 Status in Human Breast Cancer Predicts Mutation Status, Transcriptional Effects, and Patient Survival by Miller, Lance D., Smeds, Johanna, George, Joshy, Vega, Vinsensius B., Vergara, Liza, Ploner, Alexander, Pawitan, Yudi, Hall, Per, Klaar, Sigrid, Liu, Edison T., Bergh, Jonas, White, Raymond L.

“…Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by…”
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Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer by Ivshina, Anna V, George, Joshy, Senko, Oleg, Mow, Benjamin, Putti, Thomas C, Smeds, Johanna, Lindahl, Thomas, Pawitan, Yudi, Hall, Per, Nordgren, Hans, Wong, John E L, Liu, Edison T, Bergh, Jonas, Kuznetsov, Vladimir A, Miller, Lance D

“…Histologic grading of breast cancer defines morphologic subtypes informative of metastatic potential, although not without considerable interobserver…”
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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts by Pawitan, Yudi, Bjöhle, Judith, Amler, Lukas, Borg, Anna-Lena, Egyhazi, Suzanne, Hall, Per, Han, Xia, Holmberg, Lars, Huang, Fei, Klaar, Sigrid, Liu, Edison T, Miller, Lance, Nordgren, Hans, Ploner, Alexander, Sandelin, Kerstin, Shaw, Peter M, Smeds, Johanna, Skoog, Lambert, Wedrén, Sara, Bergh, Jonas

“…Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast cancer expression profiling has…”
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Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients by Calza, Stefano, Hall, Per, Auer, Gert, Bjöhle, Judith, Klaar, Sigrid, Kronenwett, Ulrike, Liu, Edison T, Miller, Lance, Ploner, Alexander, Smeds, Johanna, Bergh, Jonas, Pawitan, Yudi

“…Molecular markers and the rich biological information they contain have great potential for cancer diagnosis, prognostication and therapy prediction. So far,…”
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Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study by Hall, Per, Ploner, Alexander, Bjöhle, Judith, Huang, Fei, Lin, Chin-Yo, Liu, Edison T, Miller, Lance D, Nordgren, Hans, Pawitan, Yudi, Shaw, Peter, Skoog, Lambert, Smeds, Johanna, Wedrén, Sara, Ohd, John, Bergh, Jonas

“…Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well…”
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Treatment of Breast Cancer with Trastuzumab Can Be Directed and Optimized by Level of Pdgf-Beta Receptor in Tumors by Liu, Tao, Smeds, Johanna, Ostman, Arne, Bergh, Jonas

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Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome by FRASOR, Jonna, CHANG, Edmund C, KOMM, Barry, LIN, Chin-Yo, VEGA, Vinsensius B, LIU, Edison T, MILLER, Lance D, SMEDS, Johanna, BERGH, Jonas, KATZENELLENBOGEN, Benita S

“…The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its…”
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Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer by Lin, Chin-Yo, Ström, Anders, Li Kong, Say, Kietz, Silke, Thomsen, Jane S, Tee, Jason B S, Vega, Vinsensius B, Miller, Lance D, Smeds, Johanna, Bergh, Jonas, Gustafsson, Jan-Ake, Liu, Edison T

“…The impact of interactions between the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, on gene expression in breast cancer biology is not clear. The…”
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Significant Impact of Promoter Hypermethylation and the 540 C>T Polymorphism of CDKN2A in Cutaneous Melanoma of the Vertical Growth Phase by Straume, Oddbjørn, Smeds, Johanna, Kumar, Rajiv, Hemminki, Kari, Akslen, Lars Andreas

“…Promoter hypermethylation, mutations, and loss of heterozygosity in the CDKN2A gene as well as polymorphisms at the 3′-untranslated region were determined in…”
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A single nucleotide polymorphism in the 3′untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare by Kumar, Rajiv, Smeds, Johanna, Berggren, Petra, Straume, Oddbjørn, Rozell, Barbro Lundh, Akslen, Lars A., Hemminki, Kari

“…In this report we present the results of mutational analysis of the CDKN2B, CDKN2C, CDK4, p53 genes and 5′UTR of the CDKN2A gene in a set of 44 sporadic…”
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Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation by Smeds, Johanna, Berggren, Petra, Ma, Xin, Xu, Zhijian, Hemminki, Kari, Kumar, Rajiv

“…We determined inactivation of the CDKN2A (p16(INK4a) and p14(ARF)) gene in 21 cases of oesophageal squamous cell carcinoma (OSCC). The tumours were also…”
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Low frequency of BRAF and CDKN2A mutations in endometrial cancer by Salvesen, Helga B., Kumar, Rajiv, Stefansson, Ingunn, Angelini, Sabrina, MacDonald, Nicola, Smeds, Johanna, Jacobs, Ian J., Hemminki, Kari, Das, Soma, Akslen, Lars A.

“…Several pathways have been implicated in the pathogenesis of endometrial carcinoma. Based on recent reports, BRAF mutations provide an alternative route for…”
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Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16INK4a and p14ARF ) and p53 genes are major targets for inactivation by Smeds, Johanna, Berggren, Petra, Ma, Xin, Xu, Zhijian, Hemminki, Kari, Kumar, Rajiv

“…We determined inactivation of the CDKN2A (p16INK4a and p14ARF) gene in 21 cases of oesophageal squamous cell carcinoma (OSCC). The tumours were also analysed…”
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Analysis of G1/S checkpoint regulators in metastatic melanoma by Sauroja, Ilari, Smeds, Johanna, Vlaykova, Tatyana, Kumar, Rajiv, Talve, Lauri, Hahka-Kemppinen, Marjo, Punnonen, Kari, Jansèn, Christer T., Hemminki, Kari, Pyrhönen, Seppo

“…We have analyzed the expression of the CDKN1A (p21CIP1), CDKN1B (p27Kip1), TP53, RB1 and MDM2 proteins and tumor cell proliferation by immunohistochemical…”
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Gene expression in 16q is associated with survival and differs between Sørlie breast cancer subtypes by Wennmalm, Kristian, Calza, Stefano, Ploner, Alexander, Hall, Per, Bjöhle, Judith, Klaar, Sigrid, Smeds, Johanna, Pawitan, Yudi, Bergh, Jonas

“…We have investigated the relationship between gene expression and chromosomal positions in 402 breast cancer patients. Using an overrepresentation approach…”
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Ductal carcinoma in situ of the breast with different histopathological grades and corresponding new breast tumour events: analysis of loss of heterozygosity by Smeds, Johanna, Wärnberg, Fredrik, Norberg, Torbjörn, Nordgren, Hans, Holmberg, Lars, Bergh, Jonas

“…To compare chromosomal alterations in ductal carcinoma in situ (DCIS) of different histopathological grades and to study aberrations between primary DCIS and…”
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Polymorphic insertion of additional repeat within an area of direct 8 bp tandem repeats in the 5′-untranslated region of the p53R2 gene and cancer risk by Smeds, Johanna, Kumar, Rajiv, Hemminki, Kari

“…p53R2 is a recently cloned gene that functions in p53-induced DNA repair. In the 5′-untranslated region of the p53R2 gene two direct tandem 8 bp repeats are…”
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A novel polymorphism (-88 C>A) in the 5′ UTR of the p53R2 gene by Smeds, Johanna, Nava, Mariachiara, Kumar, Rajiv, Hemminki, Kari

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A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and P53 genes are rare by KUMAR, Rajiv, SMEDS, Johanna, BERGGREN, Petra, STRAUME, Oddbjørn, ROZELL, Barbro Lundh, AKSLEN, Lars A, HEMMINKI, Kari

“…In this report we present the results of mutational analysis of the CDKN2B, CDKN2C, CDK4, p53 genes and 5'UTR of the CDKN2A gene in a set of 44 sporadic…”
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