Search Results - "Smeds, Emanuel"

Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics by Malmström, Erik, Kilsgård, Ola, Hauri, Simon, Smeds, Emanuel, Herwald, Heiko, Malmström, Lars, Malmström, Johan

“…The plasma proteome is highly dynamic and variable, composed of proteins derived from surrounding tissues and cells. To investigate the complex processes that…”
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The role of extracellular vesicle fusion with target cells in triggering systemic inflammation by Papareddy, Praveen, Tapken, Ines, Kroh, Keshia, Varma Bhongir, Ravi Kiran, Rahman, Milladur, Baumgarten, Maria, Cim, Eda Irem, Györffy, Lilla, Smeds, Emanuel, Neumann, Ariane, Veerla, Srinivas, Olinder, Jon, Thorlacus, Henrik, Ryden, Cecilia, Bartakova, Eva, Holub, Michal, Herwald, Heiko

“…Extracellular vesicles (EVs) play a crucial role in intercellular communication by transferring bioactive molecules from donor to recipient cells. As a result,…”
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Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo by Westman, Johannes, Papareddy, Praveen, Dahlgren, Madelene W, Chakrakodi, Bhavya, Norrby-Teglund, Anna, Smeds, Emanuel, Linder, Adam, Mörgelin, Matthias, Johansson-Lindbom, Bengt, Egesten, Arne, Herwald, Heiko

“…The innate immune system relies to a great deal on the interaction of pattern recognition receptors with pathogen- or damage-associated molecular pattern…”
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Structural and oxidative investigation of a recombinant high-yielding fetal hemoglobin mutant by Kettisen, Karin, Nyblom, Maria, Smeds, Emanuel, Fago, Angela, Bülow, Leif

“…Human fetal hemoglobin (HbF) is an attractive starting protein for developing an effective agent for oxygen therapeutics applications. This requires that HbF…”
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Site-Specific Introduction of Negative Charges on the Protein Surface for Improving Global Functions of Recombinant Fetal Hemoglobin by Kettisen, Karin, Dicko, Cedric, Smeds, Emanuel, Bülow, Leif

“…Due to its compatible oxygen-transporting abilities, hemoglobin (Hb) is a protein of interest in the development of artificial oxygen therapeutics. Despite…”
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A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics by Ganesh, Vannakambadi K, Rivera, Jose J, Smeds, Emanuel, Ko, Ya-Ping, Bowden, M Gabriela, Wann, Elisabeth R, Gurusiddappa, Shivasankarappa, Fitzgerald, J Ross, Höök, Magnus

“…The fibrinogen (Fg) binding MSCRAMM Clumping factor A (ClfA) from Staphylococcus aureus interacts with the C-terminal region of the fibrinogen (Fg)…”
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Molecular Characterization of the Interaction of Staphylococcal Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMM) ClfA and Fbl with Fibrinogen by Geoghegan, Joan A., Ganesh, Vannakambadi K., Smeds, Emanuel, Liang, Xiaowen, Höök, Magnus, Foster, Timothy J.

“…The ligand-binding domain of Fbl (the fibrinogen binding protein from Staphylococcuslugdunensis) shares 60% sequence identity with ClfA (clumping factor A) of…”
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An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity by Papareddy, Praveen, Kasetty, Gopinath, Alyafei, Saud, Smeds, Emanuel, Salo-Ahen, Outi M. H., Hansson, Stefan R., Egesten, Arne, Herwald, Heiko

“…Coagulation, complement, and innate immunity are tightly interwoven and form an alliance that can be traced back to early eukaryotic evolution. Here we…”
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Heparan Sulfate Synthesized by Mouse Embryonic Stem Cells Deficient in NDST1 and NDST2 Is 6-O-Sulfated but Contains No N-Sulfate Groups by Holmborn, Katarina, Ledin, Johan, Smeds, Emanuel, Eriksson, Inger, Kusche-Gullberg, Marion, Kjellén, Lena

“…Heparan sulfate structure differs significantly between various cell types and during different developmental stages. The diversity is created during…”
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Bacillus anthracis spore entry into epithelial cells is an actin-dependent process requiring c-Src and PI3K by Xue, Qiong, Jenkins, Sarah A, Gu, Chunfang, Smeds, Emanuel, Liu, Qing, Vasan, Ranga, Russell, Brooke H, Xu, Yi

“…Dissemination of Bacillus anthracis from the respiratory mucosa is a critical step in the establishment of inhalational anthrax. Recent in vitro and in vivo…”
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Overexpression of Heparan Sulfate 6-O-Sulfotransferases in Human Embryonic Kidney 293 Cells Results in Increased N-Acetylglucosaminyl 6-O-Sulfation by Do, Anh-Tri, Smeds, Emanuel, Spillmann, Dorothe, Kusche-Gullberg, Marion

“…Heparan sulfate (HS) interacts with a variety of proteins and thus mediates numerous complex biological processes. These interactions critically depend on the…”
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Oligosaccharide Library-based Assessment of Heparan Sulfate 6-O-Sulfotransferase Substrate Specificity by Jemth, Per, Smeds, Emanuel, Do, Anh-Tri, Habuchi, Hiroko, Kimata, Koji, Lindahl, Ulf, Kusche-Gullberg, Marion

“…Heparan sulfate mediates numerous complex biological processes. Its action critically depends on the amount and the positions of O -sulfate groups (iduronyl 2-…”
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SLUSH peptides of the PSMβ family enable Staphylococcus lugdunensis to use erythrocytes as a sole source of nutrient iron by Sekar, Sharmila, Schwarzbach, Selina, Nega, Mulugeta, Bloes, Dominik Alexander, Smeds, Emanuel, Kretschmer, Dorothee, Foster, Timothy J., Heilbronner, Simon

“…During infection, the host employs nutritional immunity to restrict access to iron. Staphylococcus lugdunensis has been recognized for its ability to utilize…”
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Fibrinogen Is a Ligand for the Staphylococcus aureus Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMM) Bone Sialoprotein-binding Protein (Bbp) by Vazquez, Vanessa, Liang, Xiaowen, Horndahl, Jenny K., Ganesh, Vannakambadi K., Smeds, Emanuel, Foster, Timothy J., Hook, Magnus

“…Microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) are bacterial surface proteins mediating adherence of the microbes to components…”
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Vertebrate TFPI-2 C-terminal peptides exert therapeutic applications against Gram-negative infections by Kasetty, Gopinath, Smeds, Emanuel, Holmberg, Emelie, Wrange, Louise, Adikesavan, Selvi, Papareddy, Praveen

“…Tissue factor pathway inhibitor-2 (TFPI-2) is a serine protease inhibitor that exerts multiple physiological and patho-physiological activities involving the…”
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Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia by Flick, Matthew J., Du, XinLi, Prasad, Joni M., Raghu, Harini, Palumbo, Joseph S., Smeds, Emanuel, Höök, Magnus, Degen, Jay L.

“…Fibrinogen can support host antimicrobial containment/clearance mechanisms, yet selected pathogens appear to benefit from host procoagulants to drive bacterial…”
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Production of functional human fetal hemoglobin in Nicotiana benthamiana for development of hemoglobin-based oxygen carriers by Kanagarajan, Selvaraju, Carlsson, Magnus L.R., Chakane, Sandeep, Kettisen, Karin, Smeds, Emanuel, Kumar, Ranjeet, Ortenlöf, Niklas, Gram, Magnus, Åkerström, Bo, Bülow, Leif, Zhu, Li-Hua

“…Hemoglobin-based oxygen carriers have long been pursued to meet clinical needs by using native hemoglobin (Hb) from human or animal blood, or recombinantly…”
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Toll-like Receptor 11 (TLR11) Prevents Salmonella Penetration into the Murine Peyer Patches by Shi, Zhongcheng, Cai, Zhenyu, Yu, Jingcui, Zhang, Tingting, Zhao, Shu, Smeds, Emanuel, Zhang, Qingyuan, Wang, Fen, Zhao, Changhong, Fu, Songbin, Ghosh, Sankar, Zhang, Dekai

“…Toll-like receptors (TLRs) are key molecular sensors used by the mammalian innate immune system to detect microorganisms. Although TLR functions in colonic…”
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Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo: e1005319 by Westman, Johannes, Papareddy, Praveen, Dahlgren, Madelene W, Chakrakodi, Bhavya, Norrby-Teglund, Anna, Smeds, Emanuel, Linder, Adam, Mörgelin, Matthias, Johansson-Lindbom, Bengt, Egesten, Arne, Herwald, Heiko

“…The innate immune system relies to a great deal on the interaction of pattern recognition receptors with pathogen- or damage-associated molecular pattern…”
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A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection by Papareddy, Praveen, Rossnagel, Madlen, Doreen Hollwedel, Femke, Kilic, Gülcan, Veerla, Srinivas, Naudin, Clément, Smeds, Emanuel, Westman, Johannes, Martinez-Martinez, Irene, Egesten, Arne, de la Morena-Barrio, Maria Eugenia, Corral, Javier, Linder, Adam, Artoni, Andrea, Abbattista, Maria, Novembrino, Cristina, Herbert Brakebusch, Cord, Martinelli, Ida, Kasetty, Gopinath, Herwald, Heiko

“…Severe infectious diseases are often characterized by an overwhelming and unbalanced systemic immune response to microbial infections. Human antithrombin (hAT)…”
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