Search Results - "Smedley, James"

Structure of the Claudin-binding Domain of Clostridium perfringens Enterotoxin by Van Itallie, Christina M., Betts, Laurie, Smedley, James G., McClane, Bruce A., Anderson, James M.

“…Clostridium perfringens enterotoxin is a common cause of food-borne and antibiotic-associated diarrhea. The toxin's receptors on intestinal epithelial cells…”
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Development of a platform-based approach for the clinical production of HIV gp120 envelope glycoprotein vaccine candidates by Wolfe, Leslie S., Smedley, James G., Bubna, Niket, Hussain, Althaf, Harper, Richard, Mostafa, Sigma

“…Preclinical development of vaccine candidates is an important link between the discovery and manufacture of vaccines for use in human clinical trials. Here, an…”
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Identification of a Claudin-4 Residue Important for Mediating the Host Cell Binding and Action of Clostridium perfringens Enterotoxin by Robertson, Susan L, Smedley, James G. III, McClane, Bruce A

“…The 24-member claudin protein family plays a key role in maintaining the normal structure and function of epithelial tight junctions. Previous studies with…”
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Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins by Briggs, David C., Naylor, Claire E., Smedley, James G., Lukoyanova, Natalya, Robertson, Susan, Moss, David S., McClane, Bruce A., Basak, Ajit K.

“…Clostridium perfringens enterotoxin (CPE) is a major cause of food poisoning and antibiotic-associated diarrhea. Upon its release from C. perfringens spores,…”
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Identification of a Prepore Large-Complex Stage in the Mechanism of Action of Clostridium perfringens Enterotoxin by Smedley, James G. III, Uzal, Francisco A, McClane, Bruce A

“…Clostridium perfringens enterotoxin (CPE) is the etiological agent of the third most common food-borne illness in the United States. The enteropathogenic…”
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Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis by KOMINSKY, Scott L, TYLER, Betty, SOSNOWSKI, Jeffrey, BRADY, Kelly, DOUCET, Michele, NELL, Delissa, SMEDLEY, James G, MCCLANE, Bruce, BREM, Henry, SUKUMAR, Saraswati

“…Brain metastasis is the most commonly occurring intracranial tumor whose incidence seems to be increasing. With standard therapy, the average survival time of…”
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Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity by Smedley, James G. III, Saputo, Juliann, Parker, Jacquelyn C, Fernandez-Miyakawa, Mariano E, Robertson, Susan L, McClane, Bruce A, Uzal, Francisco A

“…Clostridium perfringens enterotoxin (CPE) causes the symptoms of a very common food poisoning. To assess whether CPE-induced cytotoxicity is necessary for…”
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Cysteine-Scanning Mutagenesis Supports the Importance of Clostridium perfringens Enterotoxin Amino Acids 80 to 106 for Membrane Insertion and Pore Formation by JIANWU CHEN, THEORET, James R, SHRESTHA, Archana, SMEDLEY, James G, MCCLANE, Bruce A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial by Madanitsa, Mwayiwawo, Kalilani, Linda, Mwapasa, Victor, van Eijk, Anna M, Khairallah, Carole, Ali, Doreen, Pace, Cheryl, Smedley, James, Thwai, Kyaw-Lay, Levitt, Brandt, Wang, Duolao, Kang'ombe, Arthur, Faragher, Brian, Taylor, Steve M, Meshnick, Steve, Ter Kuile, Feiko O

“…In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends…”
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The Cooking and Pneumonia Study (CAPS) in Malawi: Implementation of Remote Source Data Verification by Weston, William, Smedley, James, Bennett, Andrew, Mortimer, Kevin

“…Source data verification (SDV) is a data monitoring procedure which compares the original records with the Case Report Form (CRF). Traditionally, on-site SDV…”
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Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants by Robertson, Susan L, Smedley, James G. III, Singh, Usha, Chakrabarti, Ganes, Van Itallie, Christina M, Anderson, James M, McClane, Bruce A

“…Clostridium perfringens enterotoxin (CPE) binds to host cell receptors, forming a small complex precursor for two large complexes reportedly having molecular…”
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Influence of Pilin Glycosylation on Pseudomonas aeruginosa 1244 Pilus Function by Smedley, James G, Jewell, Erica, Roguskie, Jennifer, Horzempa, Joseph, Syboldt, Andrew, Stolz, Donna Beer, Castric, Peter

“…The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of nosocomial pneumonia. Among its virulence factors, the type IV pili of P. aeruginosa…”
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Effectiveness of antenatal clinics to deliver intermittent preventive treatment and insecticide treated nets for the control of malaria in pregnancy in Kenya by Hill, Jenny, Dellicour, Stephanie, Bruce, Jane, Ouma, Peter, Smedley, James, Otieno, Peter, Ombock, Maurice, Kariuki, Simon, Desai, Meghna, Hamel, Mary J, ter Kuile, Feiko O, Webster, Jayne

“…Malaria in pregnancy can have devastating consequences for mother and baby. Coverage with the WHO prevention strategy for sub-Saharan Africa of…”
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Claudin-4 Overexpression in Epithelial Ovarian Cancer Is Associated with Hypomethylation and Is a Potential Target for Modulation of Tight Junction Barrier Function Using a C-Terminal Fragment of Clostridium perfringens Enterotoxin by Litkouhi, Babak, Kwong, Joseph, Lot, Chun-Min, Smedley, James G., McClane, Bruce A., Aponte, Margarita, Gao, Zhijian, Sarno, Jennifer L., Hinners, Jennifer, Welch, William R., Berkowitz, Ross S., Mok, Samuel C., Garner, Elizabeth I.O.

“…BACKGROUND: Claudin-4, a tight junction (TJ) protein and receptor for the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE), is overexpressed…”
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Effectiveness of antenatal clinics to deliver intermittent preventive treatment and insecticide treated nets for the control of malaria in pregnancy in Mali: a household survey by Hill, Jenny, Kayentao, Kassoum, Touré, Mahamoudou, Diarwara, Sory, Bruce, Jane, Smedley, James, Doumbo, Ogobara K, ter Kuile, Feiko O, Webster, Jayne

“…WHO recommends intermittent-preventive-treatment (IPTp) with sulphadoxine-pyrimethamine (SP) and insecticide-treated-nets (ITNs) to prevent malaria in…”
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Probing the pH-Dependent Prepore to Pore Transition of Bacillus anthracis Protective Antigen with Differential Oxidative Protein Footprinting by Smedley, James G, Sharp, Joshua S, Kuhn, Jeffrey F, Tomer, Kenneth B

“…The protective antigen (PA) component of the anthrax toxin (ATx) plays an essential role in the pathogenesis of the bioterrorism bacterium Bacillus anthracis…”
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Fine Mapping of the N-Terminal Cytotoxicity Region of Clostridium perfringens Enterotoxin by Site-Directed Mutagenesis by SMEDLEY, James G, MCCLANE, And Bruce A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Crystallization and preliminary crystallographic analysis of the Clostridium perfringens enterotoxin by Briggs, David C., Smedley III, James G., McClane, Bruce A., Basak, Ajit K.

“…Clostridium perfringens is a Gram‐positive anaerobic species of bacterium that is notable for its ability to produce a plethora of toxins, including…”
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Efficacy and safety of intermittent preventive treatment and intermittent screening and treatment versus single screening and treatment with dihydroartemisinin–piperaquine for the control of malaria in pregnancy in Indonesia: a cluster-randomised, open-label, superiority trial by Ahmed, Rukhsana, Poespoprodjo, Jeanne R, Syafruddin, Din, Khairallah, Carole, Pace, Cheryl, Lukito, Theda, Maratina, Sylvia S, Asih, Puji B S, Santana-Morales, Maria A, Adams, Emily R, Unwin, Vera T, Williams, Christopher T, Chen, Tao, Smedley, James, Wang, Duolao, Faragher, Brian, Price, Richard N, ter Kuile, Feiko O

“…Plasmodium falciparum and Plasmodium vivax infections are important causes of adverse pregnancy outcomes in the Asia-Pacific region. We hypothesised that…”
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Effectiveness of Antenatal Clinics to Deliver Intermittent Preventive Treatment and Insecticide Treated Nets for the Control of Malaria in Pregnancy in Mali: A Household Survey: e92102 by Hill, Jenny, Kayentao, Kassoum, Toure, Mahamoudou, Diarwara, Sory, Bruce, Jane, Smedley, James, Doumbo, Ogobara K, Kuile, Feiko Oter, Webster, Jayne

“…Background WHO recommends intermittent-preventive-treatment (IPTp) with sulphadoxine-pyrimethamine (SP) and insecticide-treated-nets (ITNs) to prevent malaria…”
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