Search Results - "Smart, Trevor"

The desensitization gate of inhibitory Cys-loop receptors by Gielen, Marc, Thomas, Philip, Smart, Trevor G.

“…Cys-loop neurotransmitter-gated ion channels are vital for communication throughout the nervous system. Following activation, these receptors enter into a…”
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Binding, activation and modulation of Cys-loop receptors by Miller, Paul S, Smart, Trevor G

“…It is over forty years since the major neurotransmitters and their protein receptors were identified, and over twenty years since determination of the first…”
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Crystal structures of a GABA A -receptor chimera reveal new endogenous neurosteroid-binding sites by Laverty, Duncan, Thomas, Philip, Field, Martin, Andersen, Ole J, Gold, Matthew G, Biggin, Philip C, Gielen, Marc, Smart, Trevor G

“…γ-Aminobutyric acid receptors (GABA Rs) are vital for controlling excitability in the brain. This is emphasized by the numerous neuropsychiatric disorders that…”
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Physiological role for GABA A receptor desensitization in the induction of long-term potentiation at inhibitory synapses by Field, Martin, Dorovykh, Valentina, Thomas, Philip, Smart, Trevor G

“…GABA receptors (GABA Rs) are pentameric ligand-gated ion channels distributed throughout the brain where they mediate synaptic and tonic inhibition. Following…”
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GABA A R isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation by Hannan, Saad, Minere, Marielle, Harris, Joseph, Izquierdo, Pablo, Thomas, Philip, Tench, Becky, Smart, Trevor G

“…GABA receptors (GABA Rs) are the principal inhibitory neurotransmitter receptors in the central nervous system. They control neuronal excitability by synaptic…”
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GABAAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation by Hannan, Saad, Minere, Marielle, Harris, Joseph, Izquierdo, Pablo, Thomas, Philip, Tench, Becky, Smart, Trevor G.

“…GABAA receptors (GABAARs) are the principal inhibitory neurotransmitter receptors in the central nervous system. They control neuronal excitability by synaptic…”
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Cell surface expression of homomeric GABAA receptors depends on single residues in subunit transmembrane domains by Hannan, Saad, Smart, Trevor G.

“…Cell surface expression of type A GABA receptors (GABAARs) is a critical determinant of the efficacy of inhibitory neurotransmission. Pentameric GABAARs are…”
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Pre- and postsynaptic modulation of hippocampal inhibitory synaptic transmission by pregnenolone sulphate by Seljeset, Sandra, Liebowitz, Seth, Bright, Damian P., Smart, Trevor G.

“…Neurosteroids are important endogenous modulators of GABAA receptor-mediated neurotransmission within the CNS and play a vital role in maintaining normal…”
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Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses by Field, Martin, Dorovykh, Valentina, Thomas, Philip, Smart, Trevor G.

“…GABA A receptors (GABA A Rs) are pentameric ligand-gated ion channels distributed throughout the brain where they mediate synaptic and tonic inhibition…”
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CGP7930 - An allosteric modulator of GABABRs, GABAARs and inwardly-rectifying potassium channels by Hannan, Saad B., Penzinger, Reka, Mickute, Ginte, Smart, Trevor G.

“…Type-A and -B GABA receptors (GABAARs/GABABRs) control brain function and behaviour by fine tuning neurotransmission. Over-time these receptors have become…”
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Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties by Fedele, Laura, Newcombe, Joseph, Topf, Maya, Gibb, Alasdair, Harvey, Robert J., Smart, Trevor G.

“…Genetic and bioinformatic analyses have identified missense mutations in GRIN2B encoding the NMDA receptor GluN2B subunit in autism, intellectual disability,…”
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Forty Years Searching for Neurosteroid Binding Sites on GABAA Receptors by Mortensen, Martin, Bright, Damian P., Fagotti, Juliane, Dorovykh, Valentina, Cerna, Barbora, Smart, Trevor G.

“…•Neurosteroids are modulators of GABAA receptors.•Neurosteroids can potentiate, directly activate, and inhibit GABAAR function.•This review charts the…”
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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee by Huggins, John P., Smart, Trevor S., Langman, Stephen, Taylor, Louise, Young, Tim

“…A randomised, placebo-controlled clinical trial with PF-04457845, a novel irreversible fatty acid amide hydrolase-1 inhibitor, increases endocannabinoids, but…”
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Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors by Kasaragod, Vikram Babu, Mortensen, Martin, Hardwick, Steven W., Wahid, Ayla A., Dorovykh, Valentina, Chirgadze, Dimitri Y., Smart, Trevor G., Miller, Paul S.

“…Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-,…”
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GABA Potency at GABA(A) Receptors Found in Synaptic and Extrasynaptic Zones by Mortensen, Martin, Patel, Bijal, Smart, Trevor G

“…The potency of GABA is vitally important for its primary role in activating GABA(A) receptors and acting as an inhibitory neurotransmitter. Although numerous…”
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Extrasynaptic αβ subunit GABAA receptors on rat hippocampal pyramidal neurons by Mortensen, Martin, Smart, Trevor G.

“…Extrasynaptic GABAA receptors that are tonically activated by ambient GABA are important for controlling neuronal excitability. In hippocampal pyramidal…”
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Endogenous neurosteroids regulate GABA A receptors through two discrete transmembrane sites by Smart, Trevor G, da Silva, Helena M. A, Wilkins, Megan E, Hosie, Alastair M

“…Inhibitory neurotransmission mediated by GABAA receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone…”
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Distinct activities of GABA agonists at synaptic‐ and extrasynaptic‐type GABAA receptors by Mortensen, Martin, Ebert, Bjarke, Wafford, Keith, Smart, Trevor G.

“…The activation characteristics of synaptic and extrasynaptic GABAA receptors are important for shaping the profile of phasic and tonic inhibition in the…”
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Structural determinants and regulation of spontaneous activity in GABAA receptors by Sexton, Craig A., Penzinger, Reka, Mortensen, Martin, Bright, Damian P., Smart, Trevor G.

“…GABA A receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic…”
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Probing GABA A receptors with inhibitory neurosteroids by Seljeset, Sandra, Bright, Damian P, Thomas, Philip, Smart, Trevor G

“…γ-aminobutyric acid type A receptors (GABA Rs) are important components of the central nervous system and they are functionally tasked with controlling…”
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