Search Results - "Smart, Nora G."

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo by Richardson, Mike, Young, Holly, Kadoya, Kuniko, Baetge, Emmanuel E, Kelly, Olivia G, Carpenter, Melissa K, Smart, Nora G, Bang, Anne G, Eliazer, Susan, D'Amour, Kevin A, Agulnick, Alan D, Kroon, Evert, Martinson, Laura A, Cunningham, Justine

“…Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from…”
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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells by Baetge, Emmanuel E, D'Amour, Kevin A, Bang, Anne G, Eliazer, Susan, Kelly, Olivia G, Agulnick, Alan D, Smart, Nora G, Moorman, Mark A, Kroon, Evert, Carpenter, Melissa K

“…Of paramount importance for the development of cell therapies to treat diabetes is the production of sufficient numbers of pancreatic endocrine cells that…”
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Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells by Blasius, Amanda L., Arnold, Carrie N., Georgel, Philippe, Rutschmann, Sophie, Xia, Yu, Lin, Pei, Ross, Charles, Li, Xiaohong, Smart, Nora G., Beutler, Bruce

“…Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The…”
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Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis by Arnold, Carrie N, Xia, Yu, Lin, Pei, Ross, Charles, Schwander, Martin, Smart, Nora G, Müller, Ulrich, Beutler, Bruce

“…In a pedigree of C57BL/6J mice homozygous for germline mutations induced by the mutagen N-ethyl-N-nitrosourea (ENU), numerous animals died under specific…”
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Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus by Smart, Nora G, Apelqvist, Asa A, Gu, Xueying, Harmon, Erin B, Topper, James N, MacDonald, Raymond J, Kim, Seung K

“…Identification of signaling pathways that maintain and promote adult pancreatic islet functions will accelerate our understanding of organogenesis and improve…”
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Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function by Blasius, Amanda L, Brandl, Katharina, Crozat, Karine, Xia, Yu, Khovananth, Kevin, Krebs, Philippe, Smart, Nora G, Zampolli, Antonella, Ruggeri, Zaverio M, Beutler, Bruce A

“…The classical recessive coat color mutation misty (m) arose spontaneously on the DBA/J background and causes generalized hypopigmentation and localized…”
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ENU-induced phenovariance in mice: inferences from 587 mutations by Arnold, Carrie N, Barnes, Michael J, Berger, Michael, Blasius, Amanda L, Brandl, Katharina, Croker, Ben, Crozat, Karine, Du, Xin, Eidenschenk, Celine, Georgel, Philippe, Hoebe, Kasper, Huang, Hua, Jiang, Zhengfan, Krebs, Philippe, La Vine, Diantha, Li, Xiaohong, Lyon, Stephen, Moresco, Eva Marie Y, Murray, Anne R, Popkin, Daniel L, Rutschmann, Sophie, Siggs, Owen M, Smart, Nora G, Sun, Lei, Tabeta, Koichi, Webster, Victoria, Tomisato, Wataru, Won, Sungyong, Xia, Yu, Xiao, Nengming, Beutler, Bruce

“…We present a compendium of N-ethyl-N-nitrosourea (ENU)-induced mouse mutations, identified in our laboratory over a period of 10 years either on the basis of…”
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mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα by Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Nemazee, David, Beutler, Bruce

“…Null alleles of the gene encoding NEMO (NF-κB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a…”
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The Tpl2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease by Xiao, Nengming, Eidenschenk, Celine, Krebs, Philippe, Brandl, Katharina, Blasius, Amanda L, Xia, Yu, Khovananth, Kevin, Smart, Nora G, Beutler, Bruce

“…Sluggish was identified in a population of third generation mice descended from N-ethyl-N-nitrosourea-mutagenized sires. Macrophages from homozygotes exhibited…”
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GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development by Harmon, Erin B, Apelqvist, Asa A, Smart, Nora G, Gu, Xueying, Osborne, Douglas H, Kim, Seung K

“…Identification of endogenous signals that regulate expansion and maturation of organ-specific progenitor cells is a major goal in studies of organ development…”
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The Tpl2 mutation Sluggish impairs type I interferon production and increases susceptibility to group B streptococcal disease by Xiao, Nengming, Eidenschenk, Celine, Krebs, Philippe, Brandl, Katharina, Blasius, Amanda L., Xia, Yu, Khovananth, Kevin, Smart, Nora G., Beutler, Bruce

“…Sluggish was identified in a population of third generation mice descended from N-ethyl-N-nitrosourea (ENU 3 )-mutagenized sires. Macrophages from homozygotes…”
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A mutation of Ikbkg causes immune deficiency without impairing degradation of IkB[alpha] by Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Hedestam, Gunilla B Karlsson, Nemazee, David, Beutler, Bruce

“…Null alleles of the gene encoding NEMO (NF-kB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a…”
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A Mutation of Ikbkg Causes Immune Deficiency without Impairing Degradation of lkBα by Siggs, Owen M., Berger, Michael, Krebs, Philippe, Arnold, Carrie N., Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G., Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Hedestam, Gunilla B. Karlsson, Nemazee, David, Beutler, Bruce

“…Null alleles of the gene encoding NEMO (NF-κB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a…”
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A mutation of Ikbkg causes immune deficiency without impairing degradation of II[ordmBa by Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Nemazee, David, Beutler, Bruce

“…Null alleles of the gene encoding NEMO (NF-I[ordmB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a…”
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mutation of Ikbkg causes immune deficiency without impairing degradation of IκBΠby Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Nemazee, David, Beutler, Bruce

“…Null alleles of the gene encoding NEMO (NF-κB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a…”
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A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha by Siggs, Owen M, Berger, Michael, Krebs, Philippe, Arnold, Carrie N, Eidenschenk, Celine, Huber, Christoph, Pirie, Elaine, Smart, Nora G, Khovananth, Kevin, Xia, Yu, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Nemazee, David, Beutler, Bruce

“…Null alleles of the gene encoding NEMO (NF-kappaB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a…”
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GDF11 modulates NGN3 super(+) islet progenitor cell number and promotes beta- cell differentiation in pancreas development by Harmon, Erin B, Apelqvist, Aasa A, Smart, Nora G, Gu, Xueying, Osborne, Douglas H, Kim, Seung K

“…Identification of endogenous signals that regulate expansion and maturation of organ-specific progenitor cells is a major goal in studies of organ development…”
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GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development by Erin B. Harmon, Åsa A. Apelqvist, Nora G. Smart, Xueying Gu, Douglas H. Osborne, Seung K. Kim

“…Identification of endogenous signals that regulate expansion and maturation of organ-specific progenitor cells is a major goal in studies of organ development…”
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Conditional Expression of Smad7 in Pancreatic [beta] Cells Disrupts TGF-[beta] Signaling and Induces Reversible Diabetes Mellitus: e39 by Smart, Nora G, Apelqvist, Åsa A, Gu, Xueying, Harmon, Erin B, Topper, James N, MacDonald, Raymond J, Kim, Seung K

“…Identification of signaling pathways that maintain and promote adult pancreatic islet functions will accelerate our understanding of organogenesis and improve…”
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