Search Results - "Smart, Matthew J. K."

Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat by Carr, Amanda-Jayne, Vugler, Anthony A, Hikita, Sherry T, Lawrence, Jean M, Gias, Carlos, Chen, Li Li, Buchholz, David E, Ahmado, Ahmad, Semo, Ma'ayan, Smart, Matthew J K, Hasan, Shazeen, da Cruz, Lyndon, Johnson, Lincoln V, Clegg, Dennis O, Coffey, Pete J

“…Transformation of somatic cells with a set of embryonic transcription factors produces cells with the pluripotent properties of embryonic stem cells (ESCs)…”
Get full text

Stem cells in retinal regeneration: past, present and future by Ramsden, Conor M, Powner, Michael B, Carr, Amanda-Jayne F, Smart, Matthew J K, da Cruz, Lyndon, Coffey, Peter J

“…Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and…”
Get full text

Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs by Ramsden, Conor M., Nommiste, Britta, R. Lane, Amelia, Carr, Amanda-Jayne F., Powner, Michael B., J. K. Smart, Matthew, Chen, Li Li, Muthiah, Manickam N., Webster, Andrew R., Moore, Anthony T., Cheetham, Michael E., da Cruz, Lyndon, Coffey, Peter J.

“…Inherited retinal dystrophies are an important cause of blindness, for which currently there are no effective treatments. In order to study this heterogeneous…”
Get full text

Development of human embryonic stem cell therapies for age-related macular degeneration by Carr, Amanda-Jayne F, Smart, Matthew J.K, Ramsden, Conor M, Powner, Michael B, da Cruz, Lyndon, Coffey, Peter J

“…Highlights • Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults. Recent research for treating AMD has focused on…”
Get full text

Detection of residual pluripotent stem cells in cell therapy products utilizing droplet digital PCR: an international multisite evaluation study by Yasuda, Satoshi, Bando, Kiyoko, Henry, Marianne P, Libertini, Silvana, Watanabe, Takeshi, Bando, Hiroto, Chen, Connie, Fujimori, Koki, Harada, Kosuke, Kuroda, Takuya, Lemmens, Myriam, Marginean, Dragos, Moss, David, Pereira Mouriès, Lucilia, Nicholas, Nicole S, Smart, Matthew J K, Terai, Orie, Sato, Yoji

“…The presence of residual undifferentiated pluripotent stem cells (PSCs) in PSC-derived cell therapy products (CTPs) is a major safety issue for their clinical…”
Get full text

Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC) by Carter, David A., Smart, Matthew J. K., Letton, William V. G., Ramsden, Conor M., Nommiste, Britta, Chen, Li Li, Fynes, Kate, Muthiah, Manickam N., Goh, Pollyanna, Lane, Amelia, Powner, Michael B., Webster, Andrew R., da Cruz, Lyndon, Moore, Anthony T., Coffey, Peter J., Carr, Amanda-Jayne F.

“…Autosomal dominant vitreoretinochoroidopathy (ADVIRC) is a rare, early-onset retinal dystrophy characterised by distinct bands of circumferential pigmentary…”
Get full text

Neural retinal regeneration with pluripotent stem cells by Ramsden, Conor M, Powner, Michael B, Carr, Amanda-Jayne F, Smart, Matthew J K, da Cruz, Lyndon, Coffey, Peter J

“…Retinal degeneration represents a huge burden of blinding disease, and currently there are no effective treatments that reverse the most common causes of…”
Get more information

Experimental and clinical transplantation of pluripotent stem cells for cell therapy in retinal disease by Ramsden, Conor M, Powner, Michael B, Carr, Amanda-Jayne F, Smart, Matthew JK, da Cruz, Lyndon, Coffey, Peter J

“…Several clinical trials of cell based therapy for retinal degeneration are currently recruiting worldwide. This clinical translation is based on over a decade…”
Get full text