Search Results - "Smart, G."

Binding, activation and modulation of Cys-loop receptors by Miller, Paul S, Smart, Trevor G

“…It is over forty years since the major neurotransmitters and their protein receptors were identified, and over twenty years since determination of the first…”
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Cell surface expression of homomeric GABAA receptors depends on single residues in subunit transmembrane domains by Hannan, Saad, Smart, Trevor G.

“…Cell surface expression of type A GABA receptors (GABAARs) is a critical determinant of the efficacy of inhibitory neurotransmission. Pentameric GABAARs are…”
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Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses by Field, Martin, Dorovykh, Valentina, Thomas, Philip, Smart, Trevor G.

“…GABA A receptors (GABA A Rs) are pentameric ligand-gated ion channels distributed throughout the brain where they mediate synaptic and tonic inhibition…”
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Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties by Fedele, Laura, Newcombe, Joseph, Topf, Maya, Gibb, Alasdair, Harvey, Robert J., Smart, Trevor G.

“…Genetic and bioinformatic analyses have identified missense mutations in GRIN2B encoding the NMDA receptor GluN2B subunit in autism, intellectual disability,…”
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GABA and glycine as neurotransmitters: a brief history by Bowery, N G, Smart, T G

“…γ‐Aminobutyric acid (GABA) emerged as a potentially important brain chemical just over 50 years ago, but its significance as a neurotransmitter was not fully…”
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Synaptic neurotransmitter-gated receptors by Smart, Trevor G, Paoletti, Pierre

“…Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely…”
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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo by Richardson, Mike, Young, Holly, Kadoya, Kuniko, Baetge, Emmanuel E, Kelly, Olivia G, Carpenter, Melissa K, Smart, Nora G, Bang, Anne G, Eliazer, Susan, D'Amour, Kevin A, Agulnick, Alan D, Kroon, Evert, Martinson, Laura A, Cunningham, Justine

“…Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from…”
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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells by Baetge, Emmanuel E, D'Amour, Kevin A, Bang, Anne G, Eliazer, Susan, Kelly, Olivia G, Agulnick, Alan D, Smart, Nora G, Moorman, Mark A, Kroon, Evert, Carpenter, Melissa K

“…Of paramount importance for the development of cell therapies to treat diabetes is the production of sufficient numbers of pancreatic endocrine cells that…”
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Extrasynaptic αβ subunit GABAA receptors on rat hippocampal pyramidal neurons by Mortensen, Martin, Smart, Trevor G.

“…Extrasynaptic GABAA receptors that are tonically activated by ambient GABA are important for controlling neuronal excitability. In hippocampal pyramidal…”
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Distinct activities of GABA agonists at synaptic‐ and extrasynaptic‐type GABAA receptors by Mortensen, Martin, Ebert, Bjarke, Wafford, Keith, Smart, Trevor G.

“…The activation characteristics of synaptic and extrasynaptic GABAA receptors are important for shaping the profile of phasic and tonic inhibition in the…”
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Structural determinants and regulation of spontaneous activity in GABAA receptors by Sexton, Craig A., Penzinger, Reka, Mortensen, Martin, Bright, Damian P., Smart, Trevor G.

“…GABA A receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic…”
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Improving flood hazard prediction models by Smart, G. M.

“…Inaccurate components of hydrodynamic models can lead to inaccurate flood hazard simulations, particularly when models are applied to floods larger than the…”
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Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors by McLeod, Faye, Bossio, Alessandro, Marzo, Aude, Ciani, Lorenza, Sibilla, Sara, Hannan, Saad, Wilson, Gemma A., Palomer, Ernest, Smart, Trevor G., Gibb, Alasdair, Salinas, Patricia C.

“…The structural and functional plasticity of synapses is critical for learning and memory. Long-term potentiation (LTP) induction promotes spine growth and…”
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Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells by Blasius, Amanda L., Arnold, Carrie N., Georgel, Philippe, Rutschmann, Sophie, Xia, Yu, Lin, Pei, Ross, Charles, Li, Xiaohong, Smart, Nora G., Beutler, Bruce

“…Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The…”
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HEK293 cell line: A vehicle for the expression of recombinant proteins by Thomas, Philip, Smart, Trevor G.

“…The HEK cell line has been extensively used as an expression tool for recombinant proteins since it was generated over 25 years ago. Although of epithelial…”
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GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis by Sui, Yusheng, Mortensen, Martin, Yuan, Banghao, Nicholson, Martin W., Smart, Trevor G., Jovanovic, Jasmina N.

“…GABA A receptors (γ-aminobutyric acid-gated receptors type A; GABA A Rs), the major structural and functional postsynaptic components of inhibitory synapses in…”
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Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses by Smart, Trevor G, Duguid, Ian C

“…Synaptic inhibition is a vital component in the control of cell excitability within the brain. Here we report a newly identified form of inhibitory synaptic…”
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Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation by Hannan, Saad, Gerrow, Kim, Triller, Antoine, Smart, Trevor G.

“…Here, we uncover a mechanism for regulating the number of active presynaptic GABAB receptors (GABABRs) at nerve terminals, an important determinant of…”
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Optimal charging management and infrastructure planning for free-floating shared electric vehicles by Roni, Mohammad S., Yi, Zonggen, Smart, John G.

“…•Investigated infrastructure planning of free-floating electric vehicle (EV) car-sharing system.•Studied the tradeoffs between downtime of EVs and the number…”
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The impact of enzyme replacement therapy on the oral health manifestations of hypophosphatasia among children: a scoping review by Smart, G., Jensen, E. D., Poirier, B. F., Sethi, S.

“…Purpose A scoping review to describe the use of enzyme replacement therapy (ERT) in the form of asfotase alfa to decrease the severity of oral manifestations…”
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