Search Results - "Smallwood, P M"

Fibroblast Growth Factor (FGF) Homologous Factors: New Members of the FGF Family Implicated in Nervous System Development by Smallwood, Philip M., Munoz-Sanjuan, Ignacio, Tong, Patrick, Macke, Jennifer P., Stewart H. C. Hendry, Gilbert, Debra J., Copeland, Neal G., Jenkins, Nancy A., Nathans, Jeremy

“…Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a…”
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Vascular Development in the Retina and Inner Ear: Control by Norrin and Frizzled-4, a High-Affinity Ligand-Receptor Pair by Xu, Qiang, Wang, Yanshu, Dabdoub, Alain, Smallwood, Philip M, Williams, John, Woods, Chad, Kelley, Matthew W, Jiang, Li, Tasman, William, Zhang, Kang, Nathans, Jeremy

“…Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the protein product of the Norrie…”
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Frizzled-3 Is Required for the Development of Major Fiber Tracts in the Rostral CNS by Wang, Yanshu, Thekdi, Nupur, Smallwood, Philip M, Macke, Jennifer P, Nathans, Jeremy

“…Many ligand/receptor families are known to contribute to axonal growth and targeting. Thus far, there have been no reports implicating Wnts and Frizzleds in…”
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A new secreted protein that binds to Wnt proteins and inhibits their activities by Hsieh, J C, Kodjabachian, L, Rebbert, M L, Rattner, A, Smallwood, P M, Samos, C H, Nusse, R, Dawid, I B, Nathans, J

“…The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide…”
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Biochemical defects in ABCR protein variants associated with human retinopathies by Nathans, Jeremy, Sun, Hui, Smallwood, Philip M

“…Mutations in the gene encoding ABCR (ABCA4), a photoreceptor-specific ATP-binding cassette (ABC) transporter, are responsible for autosomal recessive Stargardt…”
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Identification and Characterization of All-trans-retinol Dehydrogenase from Photoreceptor Outer Segments, the Visual Cycle Enzyme That Reduces All-trans-retinal to All-trans-retinol by Rattner, Amir, Smallwood, Philip M., Nathans, Jeremy

“…Retinol dehydrogenase (RDH), the enzyme that catalyzes the reduction of all-trans-retinal to all-trans-retinol within the photoreceptor outer segment, was the…”
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Influence of thyroid hormone status on expression of genes encoding G protein subunits in the rat heart by Levine, M A, Feldman, A M, Robishaw, J D, Ladenson, P W, Ahn, T G, Moroney, J F, Smallwood, P M

“…We have studied the influence of thyroid hormone status in vivo on expression of the genes encoding guanine nucleotide-binding regulatory protein (G protein)…”
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Biochemical Characterization of Wnt-Frizzled Interactions Using a Soluble, Biologically Active Vertebrate Wnt Protein by Hsieh, Jen-Chih, Rattner, Amir, Smallwood, Philip M., Nathans, Jeremy

“…Biochemical studies of Wnt signaling have been hampered by difficulties in obtaining large quantities of soluble, biologically active Wnt proteins. In this…”
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Role of a Locus Control Region in the Mutually Exclusive Expression of Human Red and Green Cone Pigment Genes by Smallwood, Philip M., Wang, Yanshu, Nathans, Jeremy

“…Trichromacy in humans and other Old World primates evolved from a dichromatic color vision system ≈30-40 million years ago. One essential part of this…”
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A Family of Secreted Proteins Contains Homology to the Cysteine-Rich Ligand-Binding Domain of Frizzled Receptors by Rattner, Amir, Hsieh, Jen-Chih, Smallwood, Philip M., Gilbert, Debra J., Copeland, Neil G., Jenkins, Nancy A., Nathans, Jeremy

“…This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich…”
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Genetic Deficiency of the α Subunit of the Guanine Nucleotide-Binding Protein Gs as the Molecular Basis for Albright Hereditary Osteodystrophy by Levine, Michael A., Ahn, Thomas G., Klupt, Sharon F., Kaufman, Keith D., Smallwood, Philip M., Bourne, Henry R., Sullivan, Kathleen A., Van Dop, Cornelis

“…Patients who have pseudohypoparathyroidism type I associated with Albright hereditary osteodystrophy commonly have a genetic deficiency of the α subunit of the…”
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A Photoreceptor-Specific Cadherin Is Essential for the Structural Integrity of the Outer Segment and for Photoreceptor Survival by Rattner, Amir, Smallwood, Philip M., Williams, John, Cooke, Carol, Savchenko, Andrey, Lyubarsky, Arkady, Pugh, Edward N., Nathans, Jeremy

“…A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing. prCAD is expressed only in retinal…”
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Genetically Engineered Mice with an Additional Class of Cone Photoreceptors: Implications for the Evolution of Color Vision by Smallwood, Philip M., Ölveczky, Bence P., Williams, Gary L., Jacobs, Gerald H., Reese, Benjamin E., Meister, Markus, Nathans, Jeremy

“…Among eutherian mammals, only primates possess trichromatic color vision. In Old World primates, trichromacy was made possible by a visual pigment gene…”
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Isoform Diversity among Fibroblast Growth Factor Homologous Factors Is Generated by Alternative Promoter Usage and Differential Splicing by Munoz-Sanjuan, Ignacio, Smallwood, Philip M., Nathans, Jeremy

“…Fibroblast growth factor (FGF) homologous factors-1, -2, -3, and -4 (FHFs 1–4; also referred to as FGFs 11–14) comprise a separate branch of the FGF family and…”
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Mutually Exclusive Expression of Human Red and Green Visual Pigment-Reporter Transgenes Occurs at High Frequency in Murine Cone Photoreceptors by Wang, Yanshu, Smallwood, Philip M., Cowan, Mitra, Blesh, Diane, Lawler, Ann, Nathans, Jeremy

“…This study examines the mechanism of mutually exclusive expression of the human X-linked red and green visual pigment genes in their respective cone…”
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Proximal and Distal Sequences Control UV Cone Pigment Gene Expression in Transgenic Zebrafish by Luo, Wenqin, Williams, John, Smallwood, Philip M, Touchman, Jeffrey W, Roman, Laura M, Nathans, Jeremy

“…The molecular basis of cone photoreceptor-specific gene expression is largely unknown. In this study, we define cis-acting DNA sequences that control the cell…”
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Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization by Ye, Xin, Wang, Yanshu, Cahill, Hugh, Yu, Minzhong, Badea, Tudor C., Smallwood, Philip M., Peachey, Neal S., Nathans, Jeremy

“…Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5…”
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Mutation in the Gene Encoding the Stimulatory G Protein of Adenylate Cyclase in Albright's Hereditary Osteodystrophy by Patten, Jennifer L, Johns, Donald R, Valle, David, Eil, Charles, Gruppuso, Philip A, Steele, Gary, Smallwood, Philip M, Levine, Michael A

“…Albright's hereditary osteodystrophy is an autosomal dominant disorder characterized by a short stature, brachydactyly, subcutaneous ossifications, and reduced…”
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Identification and Characterization of a Conserved Family of Protein Serine/Threonine Phosphatases Homologous to Drosophila Retinal Degeneration C (rdgC) by Sherman, Patti M., Sun, Hui, Macke, Jennifer P., Williams, John, Smallwood, Philip M., Nathans, Jeremy

“…The Drosophila retinal degeneration C (rdgC) gene encodes an unusual protein serine/threonine phosphatase in that it contains at least two EF-hand motifs at…”
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A new secreted protein that binds to Wnt proteins and inhibits their activites by Nathans, Jeremy, Hsieh, Jen-Chih, Kodjabachian, Laurent, Rebbert, Martha L, Rattner, Amir, Smallwood, Philip M, Samos, Cynthia Harryman, Nusse, Roel, Dawid, Igor B

“…The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide…”
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