Search Results - "Small, Scott A"

Early Detection and Preventive Intervention in Schizophrenia: From Fantasy to Reality by Lieberman, Jeffrey A, Small, Scott A, Girgis, Ragy R

“…Scientific progress in understanding human disease can be measured by the effectiveness of its treatment. Antipsychotic drugs have been proven to alleviate…”
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Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability by Small, Scott A

“…Some of the most common and devastating disorders of the brain target the hippocampal formation. The hippocampal formation is a complex circuit of…”
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Trans-synaptic spread of tau pathology in vivo by Liu, Li, Drouet, Valerie, Wu, Jessica W, Witter, Menno P, Small, Scott A, Clelland, Catherine, Duff, Karen

“…Tauopathy in the brain of patients with Alzheimer's disease starts in the entorhinal cortex (EC) and spreads anatomically in a defined pattern. To test whether…”
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Imaging Patients with Psychosis and a Mouse Model Establishes a Spreading Pattern of Hippocampal Dysfunction and Implicates Glutamate as a Driver by Schobel, Scott A., Chaudhury, Nashid H., Khan, Usman A., Paniagua, Beatriz, Styner, Martin A., Asllani, Iris, Inbar, Benjamin P., Corcoran, Cheryl M., Lieberman, Jeffrey A., Moore, Holly, Small, Scott A.

“…The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced size. It remains unknown whether these abnormalities are mechanistically…”
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RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk by MacLeod, David A., Rhinn, Herve, Kuwahara, Tomoki, Zolin, Ari, Di Paolo, Gilbert, McCabe, Brian D., Marder, Karen S., Honig, Lawrence S., Clark, Lorraine N., Small, Scott A., Abeliovich, Asa

“…Recent genome-wide association studies have linked common variants in the human genome to Parkinson’s disease (PD) risk. Here we show that the consequences of…”
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Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease by Khan, Usman A, Liu, Li, Provenzano, Frank A, Berman, Diego E, Profaci, Caterina P, Sloan, Richard, Mayeux, Richard, Duff, Karen E, Small, Scott A

“…In the brains of Alzheimer's disease patients, the entorhinal cortex is known to show signs of early pathology. In this study, Khan et al . performed cerebral…”
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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures by Miranda, André Miguel Lopes, Lasiecka, Zofia M., Xu, Yimeng, Neufeld, Jessi, Shahriar, Sanjid, Simoes, Sabrina, Chan, Robin B., Oliveira, Tiago Gil, Small, Scott A., Di Paolo, Gilbert

“…Defects in endolysosomal and autophagic functions are increasingly viewed as key pathological features of neurodegenerative disorders. A master regulator of…”
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Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis by Small, Scott A., Gandy, Sam

“…During the first 100 years of Alzheimer's disease research, this devastating and intractable disorder has been characterized at the clinical, histological, and…”
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Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing by Knupp, Allison, Mishra, Swati, Martinez, Refugio, Braggin, Jacquelyn E., Szabo, Marcell, Kinoshita, Chizuru, Hailey, Dale W., Small, Scott A., Jayadev, Suman, Young, Jessica E.

“…SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer’s disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1…”
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Why Hippocampal Glutamate Levels Are Elevated in Schizophrenia by Guo, Jia, Rothman, Douglas L, Small, Scott A

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Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology by Nuriel, Tal, Angulo, Sergio L., Khan, Usman, Ashok, Archana, Chen, Qiuying, Figueroa, Helen Y., Emrani, Sheina, Liu, Li, Herman, Mathieu, Barrett, Geoffrey, Savage, Valerie, Buitrago, Luna, Cepeda-Prado, Efrain, Fung, Christine, Goldberg, Eliana, Gross, Steven S., Hussaini, S. Abid, Moreno, Herman, Small, Scott A., Duff, Karen E.

“…The ε4 allele of apolipoprotein E ( APOE ) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason APOE4 is associated…”
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Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia by Provenzano, Frank A., Guo, Jia, Wall, Melanie M., Feng, Xinyang, Sigmon, Hannah C., Brucato, Gary, First, Michael B., Rothman, Douglas L., Girgis, Ragy R., Lieberman, Jeffrey A., Small, Scott A.

“…We examined neuroimaging-derived hippocampal biomarkers in subjects at clinical high risk (CHR) for psychosis to further characterize the pathophysiology of…”
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Pharmacological chaperones in the age of proteomic pathology by Small, Scott A.

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in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus by Pereira, Ana C, Huddleston, Dan E, Brickman, Adam M, Sosunov, Alexander A, Hen, Rene, McKhann, Guy M, Sloan, Richard, Gage, Fred H, Brown, Truman R, Small, Scott A

“…With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal…”
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Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans by Simoes, Sabrina, Neufeld, Jessica L, Triana-Baltzer, Gallen, Moughadam, Setareh, Chen, Emily I, Kothiya, Milankumar, Qureshi, Yasir H, Patel, Vivek, Honig, Lawrence S, Kolb, Hartmuth, Small, Scott A

“…Endosomal trafficking has emerged as a defective biological pathway in Alzheimer's disease (AD), and the pathway is a source of cerebrospinal fluid (CSF)…”
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Brain regions vulnerable and resistant to aging without Alzheimer's disease by Feng, Xinyang, Guo, Jia, Sigmon, Hannah C, Sloan, Richard P, Brickman, Adam M, Provenzano, Frank A, Small, Scott A

“…'Normal aging' in the brain refers to age-related changes that occur independent of disease, in particular Alzheimer's disease. A major barrier to mapping…”
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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system by Morel, Etienne, Chamoun, Zeina, Lasiecka, Zofia M., Chan, Robin B., Williamson, Rebecca L., Vetanovetz, Christopher, Dall’Armi, Claudia, Simoes, Sabrina, Point Du Jour, Kimberly S., McCabe, Brian D., Small, Scott A., Di Paolo, Gilbert

“…Defects in endosomal sorting have been implicated in Alzheimer’s disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a…”
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Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau by Asadzadeh, Jamshid, Ruchti, Evelyne, Jiao, Wei, Limoni, Greta, MacLachlan, Catherine, Small, Scott A., Knott, Graham, Santa-Maria, Ismael, McCabe, Brian D.

“…Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many neurodegenerative…”
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Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial by Sloan, Richard P., Wall, Melanie, Yeung, Lok-Kin, Feng, Tianshu, Feng, Xinyang, Provenzano, Frank, Schroeter, Hagen, Lauriola, Vincenzo, Brickman, Adam M., Small, Scott A.

“…With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted…”
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The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport by Bhalla, Akhil, Vetanovetz, Christopher P, Morel, Etienne, Chamoun, Zeina, Di Paolo, Gilbert, Small, Scott A

“…Abstract The retromer complex plays an important role in intracellular transport, is highly expressed in the hippocampus, and has been implicated in the…”
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