Search Results - "Slusarchyk, D A"

BMS-201620: a selective beta 3 agonist by Washburn, W.N., Sun, C.-Q., Bisacchi, G., Wu, G., Cheng, P.T., Sher, P.M., Ryono, D., Gavai, A.V., Poss, K., Girotra, R.N., McCann, P.J., Mikkilineni, A.B., Dejneka, T.C., Wang, T.C., Merchant, Z., Morella, M., Arbeeny, C.M., Harper, T.W., Slusarchyk, D.A., Skwish, S., Russell, A.D., Allen, G.T., Tesfamariam, B., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Young, D., Dickinson, K.E., Seymour, A.A.

“…Graphic A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human β 3 adrenergic receptor agonist…”
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Beta 3 agonists. Part 1: evolution from inception to BMS-194449 by Washburn, W.N., Sher, P.M., Poss, K.M., Girotra, R.N., McCann, P.J., Gavai, A.V., Mikkilineni, A.B., Mathur, A., Cheng, P., Dejneka, T.C., Sun, C.Q., Wang, T.C., Harper, T.W., Russell, A.D., Slusarchyk, D.A., Skwish, S., Allen, G.T., Hillyer, D.E., Frohlich, B.H., Abboa-Offei, B.E., Cap, M., Waldron, T.L., George, R.J., Tesfamariam, B., Ciosek, C.P., Ryono, D., Young, D.A., Dickinson, K.E., Seymour, A.A., Arbeeny, C.M., Gregg, R.E.

“…Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with…”
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α-Phosphonosulfonic Acids:  Potent and Selective Inhibitors of Squalene Synthase by Magnin, David R, Biller, Scott A, Chen, Ying, Dickson, John K, Fryszman, Olga M, Lawrence, R. Michael, Logan, Janette V. H, Sieber-McMaster, Ellen S, Sulsky, Richard B, Traeger, Sarah C, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A, Ciosek, Carl P

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Arylpropanolamines : Selective β3 agonists arising from strategies to mitigate phase I metabolic transformations by WASHBURN, W. N, HARPER, T. W, DEJNEKA, T, AHMED, S, CARINGAL, Y, HANGELAND, J, ZHANG, M, CHENG, P. T. W, RUSSELL, A. D, SKWISH, S, SLUSARCHYK, D. A, ALLEN, G. T, WU, G, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, GEORGE, R. J, TESFAMARIAM, B, DICKINSON, K. E, SEYMOUR, A. A, SHER, P. M, GODFREY, J. D, MCCANN, P, GIROTRA, R, SHAO, C, ZHANG, H, GAVAI, A, MIKKILINENI, A

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BMS-196085 : A potent and selective full agonist of the human β3 adrenergic receptor by GAVAI, A. V, SHER, P. M, WANG, T. C, SUN, C. Q, SLUSARCHYK, D. A, SKWISH, S, ALLEN, G. T, HILLYER, D. E, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, MIKKILINENI, A. B, GEORGE, R. J, TESFAMARIAM, B, HARPER, T. W, CIOSEK, C. P, YOUNG, D. A, DICKINSON, K. E, SEYMOUR, A. A, ARBEENY, C. M, WASHBURN, W. N, POSS, K. M, MCCANN, P. J, GIROTRA, R. N, FISHER, L. G, WU, G, BEDNARZ, M. S, MATHUR, A

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Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo by Ciosek, C P, Magnin, D R, Harrity, T W, Logan, J V, Dickson, J K, Gordon, E M, Hamilton, K A, Jolibois, K G, Kunselman, L K, Lawrence, R M

“…Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl diphosphate to form squalene at the final branchpoint of the cholesterol…”
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BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor by Gavai, A V, Sher, P M, Mikkilineni, A B, Poss, K M, McCann, P J, Girotra, R N, Fisher, L G, Wu, G, Bednarz, M S, Mathur, A, Wang, T C, Sun, C Q, Slusarchyk, D A, Skwish, S, Allen, G T, Hillyer, D E, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Harper, T W, Ciosek, Jr, C P, Young, D A, Dickinson, K E, Seymour, A A, Arbeeny, C M, Washburn, W N

“…A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR…”
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1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate by Magnin, David R, Dickson, John K, Logan, Janette V, Lawrence, R. Michael, Chen, Ying, Sulsky, Richard B, Ciosek, Carl P, Biller, Scott A, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A

“…Inhibitors of squalene synthase have the potential to be superior cholesterol-lowering agents. We previously disclosed that lipophilic 1,1-bisphosphonates I…”
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Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety by Robl, Jeffrey A, Duncan, Laurelee A, Pluscec, Jelka, Karanewsky, Donald S, Gordon, Eric M, Ciosek, Carl P, Rich, Lois C, Dehmel, Viviane C, Slusarchyk, Dorothy A

“…A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionally have been prepared and were evaluated for their ability to inhibit…”
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Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations by Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, P T W, Russell, A D, Skwish, S, Slusarchyk, D A, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, K E, Seymour, A A, Sher, P M

“…Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta(3) agonists is complicated by their propensity to undergo…”
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Arylpropanolamines: Selective beta sub(3) agonists arising from strategies to mitigate phase I metabolic transformations by Washburn, W N, Harper, T W, Wu, G, Godfrey, J D, McCann, P, Girotra, R, Shao, C, Zhang, H, Gavai, A, Mikkilineni, A, Dejneka, T, Ahmed, S, Caringal, Y, Hangeland, J, Zhang, M, Cheng, PTW, Russell, AD, Skwish, S, Slusarchyk, DA, Allen, G T, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Dickinson, KE, Seymour, A A, Sher, P M

“…Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta sub(3) agonists is complicated by their propensity to undergo…”
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Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors:  Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase by Lawrence, R. Michael, Biller, Scott A, Dickson, John K, Logan, Janette V. H, Magnin, David R, Sulsky, Richard B, DiMarco, John D, Gougoutas, Jack Z, Beyer, Barbara D, Taylor, Susan C, Lan, Shih-Jung, Ciosek, Carl P, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Slusarchyk, Dorothy A

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Phosphorus-containing inhibitors of HMG-CoA reductase. II, Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety by ROBL, J. A, DUNCAN, L. A, OBRIEN, K. A, PLUSCEC, J, KARANEWSKY, D. S, GORDON, E. M, CIOSEK, C. P, RICH, L. C, DEHMEL, V. C, SLUSARCHYK, D. A, HARRITY, T. W

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