Search Results - "Slott, Valerie L."

Semen Quality and Reproductive Health of Young Czech Men Exposed to Seasonal Air Pollution by Selevan, Sherry G., Borkovec, Libor, Slott, Valerie L., Zudová, Zdena, Rubes̆, Jir̆í, Evenson, Donald P., Perreault, Sally D.

“…This study of male reproductive health in the Czech Republic resulted from community concern about potential adverse effects of air pollution. We compared…”
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Importance of glutathione in the acquisition and maintenance of sperm nuclear decondensing activity in maturing hamster oocytes by Perreault, Sally D., Barbee, Randy R., Slott, Valerie L.

“…Sperm nuclear decondensing activity in mammalian oocytes is dependent upon the maturational state of the oocyte. It is maximal in mature, metaphase II oocytes…”
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Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants by Linder, R E, Strader, L F, Slott, V L, Suarez, J D

“…Multiple endpoints of spermatotoxicity in short duration tests (1-5 days exposure; 2.5-week assay interval) were investigated in a number of chemicals reported…”
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Rat sperm motility analysis: methodologic considerations by Slott, V L, Suarez, J D, Perreault, S D

“…The objective of these studies was to optimize conditions for computer-assisted sperm analysis (CASA) of rat epididymal spermatozoa. Methodologic issues…”
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Protection of rat embryos in culture against the embryotoxicity of acrolein using exogenous glutathione by Slott, V L, Hales, B F

“…The aldehyde acrolein is embryotoxic in vivo and in vitro. Since acrolein is reactive towards thiols, glutathione was evaluated for its protective effects…”
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Method of euthanasia does not affect sperm motility in the laboratory rat by Slott, V L, Linder, R E, Dyer, C J

“…To determine if anesthetic agents used in laboratory animal euthanasia affected sperm motion parameters, rats (n = 10 per group) were euthanized by one of 5…”
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Enhancement of the embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitro by Slott, V L, Hales, B F

“…The intracellular thiol glutathione is known to protect cells against the toxicity of certain drugs and reactive intermediates. In this study, the role of…”
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Effect of glutathione depletion by buthionine sulfoximine on rat embryonic development in vitro by Slott, V L, Hales, B F

“…The intracellular thiol glutathione has many functions within cells including protection against xenobiotic and oxidative damage, and a role in protein and DNA…”
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Sperm motion predicts fertility in male hamsters treated with alpha-chlorohydrin by Slott, V. L, Jeffay, S. C, Dyer, C. J, Barbee, R. R, Perreault, S. D

“…An understanding of the relationship between altered sperm motion and sperm function (fertility) is important when interpreting the biological significance of…”
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Regulation of the teratogenicity of acrolein in the rat by Slott, Valerie L

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Role of the 4-hydroxy intermediate in the in vitro embryotoxicity of cyclophosphamide and dechlorocyclophosphamide by Slott, V L, Hales, B F

“…Cyclophosphamide must be metabolically activated to produce malformations in cultured rat embryos. A 4-hydroxylated intermediate, 4-hydroxycyclophosphamide is…”
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Synchronous assessment of sperm motility and fertilizing ability in the hamster following treatment with alpha-chlorohydrin by Slott, V. L, Jeffay, S. C, Suarez, J. D, Barbee, R. R, Perreault, S. D

“…To Investigate the relationship between sperm motion parameters and fertilizing ability, a model was developed to assess both of these endpoints synchronously…”
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Sodium 2-mercaptoethane sulfonate protection against cyclophosphamide-induced teratogenicity in rats by Slott, V L, Hales, B F

“…Certain deleterious effects of cyclophosphamide, for example urotoxicity, can be prevented by the administration of thiol compounds such as 2-mercaptoethane…”
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Unilateral depletion of testicular glutathione levels in the rat following intratesticular injections of diethylmaleate and buthionine sulfoximine by Slott, V L, Linder, R E, Strader, L F, Perreault, S D

“…A method was developed to selectively deplete glutathione (GSH) in a single rat testis. Using intratesticular injections of a mixture of two GSH-depleting…”
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Optimization of the Hamilton-Thorn computerized sperm motility analysis system for use with rat spermatozoa in toxicological studies by Slott, V L, Suarez, J D, Poss, P M, Linder, R E, Strader, L F, Perreault, S D

“…To optimize the Hamilton-Thorn Motility Analyzer (HTM; Hamilton-Thorn Research, Beverly, MA) for use in reproductive toxicology studies with rat spermatozoa,…”
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Teratogenicity and embryolethality of acrolein and structurally related compounds in rats by Slott, V L, Hales, B F

“…Acrolein, a metabolite of the anticancer agent cyclophosphamide, is teratogenic to rats after intraamniotic administration. It is not known whether acrolein or…”
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Acute inhalation exposure to epichlorohydrin transiently decreases rat sperm velocity by Slott, V L, Suarez, J D, Simmons, J E, Perreault, S D

“…The effect of inhaled epichlorohydrin on rat sperm motility characteristics was evaluated. Male F-344 rats were exposed to 100 ppm epichlorhydrin via…”
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The embryolethality and teratogenicity of acrolein in cultured rat embryos by Slott, V L, Hales, B F

“…Acrolein, a three-carbon unsaturated aldehyde, is teratogenic to rats in vivo following intraamniotic administration but has been reported not to be…”
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