Search Results - "Slot, Jason"

The evolution of fungal metabolic pathways by Wisecaver, Jennifer H, Slot, Jason C, Rokas, Antonis

“…Fungi contain a remarkable range of metabolic pathways, sometimes encoded by gene clusters, enabling them to digest most organic matter and synthesize an array…”
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CLOCI: unveiling cryptic fungal gene clusters with generalized detection by Konkel, Zachary, Kubatko, Laura, Slot, Jason C

“…Abstract Gene clusters are genomic loci that contain multiple genes that are functionally and genetically linked. Gene clusters collectively encode diverse…”
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Horizontal Transfer of a Large and Highly Toxic Secondary Metabolic Gene Cluster between Fungi by Slot, Jason C., Rokas, Antonis

“…Genes involved in intermediary and secondary metabolism in fungi are frequently physically linked or clustered. For example, in Aspergillus nidulans the entire…”
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Metabolic gene clusters, fungal diversity, and the generation of accessory functions by Slot, Jason C, Gluck-Thaler, Emile

“…•Many of life’s adaptive accessory functions are encoded in metabolic gene clusters.•Cluster evolution is intertwined with the processes generating accessory…”
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Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens by Gluck-Thaler, Emile, Slot, Jason C

“…  First in bacteria, and more recently in microscopic and even multicellular eukaryotes, horizontal gene transfer (HGT) has been implicated in genomic and…”
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Fungal Gene Cluster Diversity and Evolution by Slot, Jason C

“…Metabolic gene clusters (MGCs) have provided some of the earliest glimpses at the biochemical machinery of yeast and filamentous fungi. MGCs encode diverse…”
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The Evolutionary Imprint of Domestication on Genome Variation and Function of the Filamentous Fungus Aspergillus oryzae by Gibbons, John G., Salichos, Leonidas, Slot, Jason C., Rinker, David C., McGary, Kriston L., King, Jonas G., Klich, Maren A., Tabb, David L., McDonald, W. Hayes, Rokas, Antonis

“…The domestication of animals, plants, and microbes fundamentally transformed the lifestyle and demography of the human species [1]. Although the genetic and…”
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Multiple GAL pathway gene clusters evolved independently and by different mechanisms in fungi by Slot, Jason C, Rokas, Antonis

“…A notable characteristic of fungal genomes is that genes involved in successive steps of a metabolic pathway are often physically linked or clustered. To…”
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Specialized plant biochemistry drives gene clustering in fungi by Gluck-Thaler, Emile, Slot, Jason C.

“…The fitness and evolution of prokaryotes and eukaryotes are affected by the organization of their genomes. In particular, the physical clustering of genes can…”
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Comparative genomics of biotechnologically important yeasts by Riley, Robert, Haridas, Sajeet, Wolfe, Kenneth H., Lopes, Mariana R., Hittinger, Chris Todd, Göker, Markus, Salamov, Asaf A., Wisecaver, Jennifer H., Long, Tanya M., Calvey, Christopher H., Aerts, Andrea L., Barry, Kerrie W., Choi, Cindy, Clum, Alicia, Coughlan, Aisling Y., Deshpande, Shweta, Douglass, Alexander P., Hanson, Sara J., Klenk, Hans-Peter, LaButti, Kurt M., Lapidus, Alla, Lindquist, Erika A., Lipzen, Anna M., Meier-Kolthoff, Jan P., Ohm, Robin A., Otillar, Robert P., Pangilinan, Jasmyn L., Peng, Yi, Rokas, Antonis, Rosa, Carlos A., Scheuner, Carmen, Sibirny, Andriy A., Slot, Jason C., Stielow, J. Benjamin, Sun, Hui, Kurtzman, Cletus P., Blackwell, Meredith, Grigoriev, Igor V., Jeffries, Thomas W.

“…Ascomycete yeasts are metabolically diverse, with great potential for biotechnology. Here, we report the comparative genome analysis of 29 taxonomically and…”
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Horizontal transfer of a nitrate assimilation gene cluster and ecological transitions in fungi: a phylogenetic study by Slot, Jason C, Hibbett, David S

“…High affinity nitrate assimilation genes in fungi occur in a cluster (fHANT-AC) that can be coordinately regulated. The clustered genes include nrt2, which…”
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Diversification of Fungal Chitinases and Their Functional Differentiation in Histoplasma capsulatum by Goughenour, Kristie D, Whalin, Janice, Slot, Jason C, Rappleye, Chad A

“…Abstract Chitinases enzymatically hydrolyze chitin, a highly abundant and utilized polymer of N-acetyl-glucosamine. Fungi are a rich source of chitinases;…”
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Giant Starship Elements Mobilize Accessory Genes in Fungal Genomes by Gluck-Thaler, Emile, Ralston, Timothy, Konkel, Zachary, Ocampos, Cristhian Grabowski, Ganeshan, Veena Devi, Dorrance, Anne E., Niblack, Terry L., Wood, Corlett W., Slot, Jason C., Lopez-Nicora, Horacio D., Vogan, Aaron A.

“…Abstract Accessory genes are variably present among members of a species and are a reservoir of adaptive functions. In bacteria, differences in gene…”
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Ecology: Fungal Mimics Dupe Animals by Transforming Plants by Slot, Jason C., Kasson, Matt T.

“…Many fungi transform host tissues to benefit their own reproduction. A recent study investigates a fungus that converts its plant host’s reproductive tissues…”
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Ecology: Fungal mimics dupe animals by transforming plants by Slot, Jason C., Kasson, Matt T.

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Physical linkage of metabolic genes in fungi is an adaptation against the accumulation of toxic intermediate compounds by McGary, Kriston L., Slot, Jason C., Rokas, Antonis

“…Genomic analyses have proliferated without being tied to tangible phenotypes. For example, although coordination of both gene expression and genetic linkage…”
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A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry by Castro-Moretti, Fernanda R, Cocuron, Jean-Christophe, Castillo-Gonzalez, Humberto, Escudero-Leyva, Efrain, Chaverri, Priscila, Guerreiro-Filho, Oliveiro, Slot, Jason C, Alonso, Ana Paula

“…Products of plant secondary metabolism, such as phenolic compounds, flavonoids, alkaloids, and hormones, play an important role in plant growth, development,…”
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Iterative l‐Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication by Blei, Felix, Fricke, Janis, Wick, Jonas, Slot, Jason C., Hoffmeister, Dirk

“…Psilocybe mushrooms are best known for their l‐tryptophan‐derived psychotropic alkaloid psilocybin. Dimethylation of norbaeocystin, the precursor of…”
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The Architecture of Metabolism Maximizes Biosynthetic Diversity in the Largest Class of Fungi by Gluck-Thaler, Emile, Haridas, Sajeet, Binder, Manfred, Grigoriev, Igor V, Crous, Pedro W, Spatafora, Joseph W, Bushley, Kathryn, Slot, Jason C

“…Abstract Ecological diversity in fungi is largely defined by metabolic traits, including the ability to produce secondary or “specialized” metabolites (SMs)…”
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Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes by Franco, Mario E. E., Wisecaver, Jennifer H., Arnold, A. Elizabeth, Ju, Yu‐Ming, Slot, Jason C., Ahrendt, Steven, Moore, Lillian P., Eastman, Katharine E., Scott, Kelsey, Konkel, Zachary, Mondo, Stephen J., Kuo, Alan, Hayes, Richard D., Haridas, Sajeet, Andreopoulos, Bill, Riley, Robert, LaButti, Kurt, Pangilinan, Jasmyn, Lipzen, Anna, Amirebrahimi, Mojgan, Yan, Juying, Adam, Catherine, Keymanesh, Keykhosrow, Ng, Vivian, Louie, Katherine, Northen, Trent, Drula, Elodie, Henrissat, Bernard, Hsieh, Huei‐Mei, Youens‐Clark, Ken, Lutzoni, François, Miadlikowska, Jolanta, Eastwood, Daniel C., Hamelin, Richard C., Grigoriev, Igor V., U’Ren, Jana M.

“…Summary Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the…”
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