Antioxidant role of plasma carotenoids in bronchopulmonary dysplasia in preterm infants

Oxidative stress is implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) and consequently, it might be theorized that sufficient antioxidant defenses are needed to prevent BPD. We hypothesized that, except for vitamins E and A, carotenoids may be important in this defense. Carotenoids...

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Bibliographic Details
Published in:	International journal for vitamin and nutrition research Vol. 79; no. 5-6; pp. 288 - 296
Main Authors:	Vogelsang, Annelies, Lingen, Richard A. van, Slootstra, Janine, Dikkeschei, Bert D, Kollen, Boudewijn J, Schaafsma, Anne, Zoeren-Grobben, Diny van
Format:	Journal Article
Language:	English
Published:	Bern Huber 01-09-2009
Subjects:	alpha-Tocopherol - blood antioxidant activity antioxidants Antioxidants - metabolism Biological and medical sciences blood plasma bronchopulmonary dysplasia Bronchopulmonary Dysplasia - blood carotenoids Carotenoids - blood Cholesterol - blood Cohort Studies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans infant feeding infant nutrition Infant, Newborn Infant, Premature infants Logistic Models Male Multivariate Analysis nutrition assessment nutritional status oxidative stress Oxidative Stress - physiology parenteral feeding premature birth Prospective Studies Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin A - blood Human Premature Lung disease carotenoids Respiratory disease antioxidants preterm infants bronchopulmonary disease Antioxidant Bronchopulmonary Blood plasma Newborn diseases Prematurity Bronchus disease Bronchopulmonary dysplasia Carotenoid
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Summary:	Oxidative stress is implicated in the pathogenesis of bronchopulmonary dysplasia (BPD) and consequently, it might be theorized that sufficient antioxidant defenses are needed to prevent BPD. We hypothesized that, except for vitamins E and A, carotenoids may be important in this defense. Carotenoids are present in human milk; however, they are not added to parenteral nutrition, the main food source of preterm infants in the first week of life. To evaluate prospectively the role of carotenoids in BPD in a cohort of preterm infants. The plasma concentrations of F(2alpha)-isoprostane, alpha- and beta-carotene, lycopene, lutein, vitamin A, and the vitamin E/cholesterol ratio were studied at days 1, 3, and 7 in a cohort of 109 preterm infants, of whom 19 had BPD. When comparing the BPD and control group, infants in the BPD group were younger (p<0.001) and beta-carotene (day 7, p<0.01) and vitamin A concentrations were lower (days 3 and 7, p<0.001). Lycopene, lutein, alpha-carotene, vitamin E, and F(2alpha)-isoprostane concentrations did not differ between groups. Plasma beta-carotene and vitamin A concentrations are lower in BPD infants which may result in a reduction of their antioxidant protection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0300-9831 1664-2821
DOI:	10.1024/0300-9831.79.56.288