Search Results - "Slomiany, Mark G."

Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells by Toole, Bryan P, Slomiany, Mark G

“…Abstract Hyaluronan not only is an important structural component of extracellular matrices but also interacts instructively with cells during embryonic…”
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Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells by SLOMIANY, Mark G, DANIEL GRASS, G, ROBERTSON, Angela D, YANG, Xiao Y, MARIA, Bernard L, BEESON, Craig, TOOLE, Bryan P

“…Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug resistance. Emmprin (CD147;…”
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Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides by SLOMIANY, Mark G, LU DAI, TOLLIVER, Lauren B, DANIEL GRASS, G, YIPING ZENG, TOOLE, Bryan P

“…Purpose: CD44 is one of the most common markers used for identification of highly tumorigenic subpopulations of human carcinoma cells, but little is known…”
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Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion by Slomiany, Mark G, Rosenzweig, Steven A

“…Hypoxia-induced stress plays a central role in retinal vascular disease and cancer. Increased hypoxia-inducible factor-1 alpha (Hif-1 alpha) expression leads…”
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Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma by Slomiany, Mark G, Black, Leigh Ann, Kibbey, Megan M, Tingler, Melissa A, Day, Terry A, Rosenzweig, Steven A

“…Abstract IGF-1 receptor (IGF-1R) signaling is associated with increased tumorigenesis of epithelial cancers. In light of recent epidemiological studies…”
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Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance by Toole, Bryan P, Slomiany, Mark G

“…Abstract Hyaluronan not only is an important structural component of extracellular matrices but also interacts with cells during dynamic cell processes such as…”
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IGF‐dependent dynamic modulation of a protease cleavage site in the intrinsically disordered linker domain of human IGFBP2 by Jaipuria, Garima, Shet, Divya, Malik, Shahid, Swain, Monalisa, Atreya, Hanudatta S., Galea, Charles A., Slomiany, Mark G., Rosenzweig, Steven A., Forbes, Briony E., Norton, Raymond S., Mondal, Somnath

“…Functional regulation via conformational dynamics is well known in structured proteins but less well characterized in intrinsically disordered proteins and…”
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Direct Activation of Emmprin and Associated Pathogenesis by an Oncogenic Herpesvirus by ZHIQIANG QIN, LU DAI, SLOMIANY, Mark G, TOOLE, Bryan P, PARSONS, Chris

“…Emmprin (extracellular matrix metalloproteinase inducer) is a multifunctional glycoprotein expressed by cancer cells and stromal cells in the tumor…”
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CD147-Dependent Heterogeneity in Malignant and Chemoresistant Properties of Cancer Cells by Dai, Lu, Guinea, Maria C, Slomiany, Mark G, Bratoeva, Momka, Grass, G. Daniel, Tolliver, Lauren B, Maria, Bernard L, Toole, Bryan P

“…CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a member of the Ig superfamily, is widespread in normal tissues, but highly…”
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Abrogating Drug Resistance in Malignant Peripheral Nerve Sheath Tumors by Disrupting Hyaluronan-CD44 Interactions with Small Hyaluronan Oligosaccharides by SLOMIANY, Mark G, LU DAI, BOMAR, Paul A, KNACKSTEDT, Thomas J, KRANC, D. Alex, TOLLIVER, Lauren, MARIA, Bernard L, TOOLE, Bryan P

“…Malignant peripheral nerve sheath tumors (MPNST) develop in approximately 10% of neurofibromatosis type-1 patients and are a major contributing factor to…”
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IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1α expression and activity in retinal pigment epithelial cell line D407 by SLOMIANY, Mark G, ROSENZWEIG, Steven A

“…To examine insulin-like growth factor (IGF)-1 stimulation of expression of hypoxia inducible factor (HIF)-1 alpha and secretion of vascular endothelial growth…”
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High-yield bacterial expression and structural characterization of recombinant human insulin-like growth factor binding protein-2 by Swain, Monalisa, Slomiany, Mark G., Rosenzweig, Steven A., Atreya, Hanudatta S.

“…The diverse biological activities of the insulin-like growth factors (IGF-1 and IGF-2) are mediated by the IGF-1 receptor (IGF-1R). These actions are modulated…”
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Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19 by Slomiany, Mark G, Rosenzweig, Steven A

“…Hypoxia-induced physiological stress plays a central role in various neovascular diseases of the eye. Increased expression of hypoxia-inducible factor 1alpha…”
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IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma by Slomiany, Mark G., Black, Leigh Ann, Kibbey, Megan M., Day, Terry A., Rosenzweig, Steven A.

“…Elevated vascular endothelial growth factor (VEGF) levels correlate with increased progression and poor prognosis of head and neck squamous cell carcinomas…”
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Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent by Lucas, J T, Salimath, B P, Slomiany, M G, Rosenzweig, S A

“…We previously reported a vascular endothelial growth factor (VEGF) autocrine loop in head and neck squamous cell carcinoma (HNSCC) cell lines, supporting a…”
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IGF-1-Induced VEGF and IGFBP-3 Secretion Correlates with Increased HIF-1{alpha} Expression and Activity in Retinal Pigment Epithelial Cell Line D407 by Slomiany, Mark G, Rosenzweig, Steven A

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CHAPTER 2 - Hyaluronan–CD44 Interactions and Chemoresistance in Cancer Cells by Slomiany, Mark G., Toole, Bryan P.

“…Hyaluronan and CD44 influence drug resistance at several different levels, namely, cell survival signaling pathways, drug transporter expression and activity,…”
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