Search Results - "Sloetjes, Annet"

Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage by van den Bosch, Martijn H, Blom, Arjen B, Sloetjes, Annet W, Koenders, Marije I, van de Loo, Fons A, van den Berg, Wim B, van Lent, Peter L, van der Kraan, Peter M

“…Proteins from the Wnt signaling pathway are very important for joint development. Curiously, osteoarthritis (OA) is thought to be a recapitulation of…”
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S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium by van Kooten, Nienke J T, Blom, Arjen B, Teunissen van Manen, Iris J, Theeuwes, Wessel F, Roth, Johannes, Gorris, Mark A J, Walgreen, Birgitte, Sloetjes, Annet W, Helsen, Monique M, Vitters, Elly L, van Lent, Peter L E M, Koëter, Sander, van der Kraan, Peter M, Vogl, Thomas, van den Bosch, Martijn H J

“…Macrophages are key orchestrators of the osteoarthritis (OA)-associated inflammatory response. Macrophage phenotype is dependent on environmental cues like the…”
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S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll‐like receptor 4: Implications for bone destruction in murine antigen‐induced arthritis by Grevers, Lilyanne C., de Vries, Teun J., Vogl, Thomas, Abdollahi‐Roodsaz, Shahla, Sloetjes, Annet W., Leenen, Pieter J. M., Roth, Johannes, Everts, Vincent, van den Berg, Wim B., van Lent, Peter L. E. M.

“…Objective Rheumatoid arthritis, which is associated with elevated levels of S100A8 and S100A9, is characterized by severe bone erosions caused by enhanced…”
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Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis by Di Ceglie, Irene, Ascone, Giuliana, Cremers, Niels A J, Sloetjes, Annet W, Walgreen, Birgitte, Vogl, Thomas, Roth, Johannes, Verbeek, J Sjef, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van den Bosch, Martijn H J, van Lent, Peter L E M

“…Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ…”
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S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis by Geven, Edwin J W, van den Bosch, Martijn H J, Di Ceglie, Irene, Ascone, Giuliana, Abdollahi-Roodsaz, Shahla, Sloetjes, Annet W, Hermann, Sven, Schäfers, Michael, van de Loo, Fons A J, van der Kraan, Peter M, Koenders, Marije I, Foell, Dirk, Roth, Johannes, Vogl, Thomas, van Lent, Peter L E M

“…Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a…”
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High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis by Ascone, Giuliana, Di Ceglie, Irene, van den Bosch, Martijn H J, Kruisbergen, Nik N L, Walgreen, Birgitte, Sloetjes, Annet W, Lindhout, Ernst, Joosten, Leo A B, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van Lent, Peter L E M

“…In this study, we used hypercholesterolaemic apolipoprotein E-deficient (Apoe-/-) mice to investigate LDL/oxLDL effect on synovial inflammation and cartilage…”
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S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis by Cremers, Niels A. J., van den Bosch, Martijn H. J., van Dalen, Stephanie, Di Ceglie, Irene, Ascone, Giuliana, van de Loo, Fons, Koenders, Marije, van der Kraan, Peter, Sloetjes, Annet, Vogl, Thomas, Roth, Johannes, Geven, Edwin J. W., Blom, Arjen B., van Lent, Peter L. E. M.

“…Background Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets…”
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Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis by van den Bosch, Martijn H., Blom, Arjen B., Schelbergen, Rik F. P., Vogl, Thomas, Roth, Johannes P., Slöetjes, Annet W., van den Berg, Wim B., van der Kraan, Peter M., van Lent, Peter L. E. M.

“…Objective Both alarmins S100A8/A9 and canonical Wnt signaling have been found to play active roles in the development of experimental osteoarthritis (OA)…”
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Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis by van Lent, Peter L. E. M., Blom, Arjen B., Schelbergen, Rik F. P., Slöetjes, Annet, Lafeber, Floris P. J. G., Lems, Willem F., Cats, Hans, Vogl, Thomas, Roth, Johannes, van den Berg, Wim B.

“…Objective To investigate whether alarmins S100A8 and S100A9 are involved in mediating cartilage destruction during murine and human osteoarthritis (OA)…”
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Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4 by Schelbergen, Rik F. P., Blom, Arjen B., van den Bosch, Martijn H. J., Slöetjes, Annet, Abdollahi-Roodsaz, Shahla, Schreurs, B. Wim, Mort, John S., Vogl, Thomas, Roth, Johannes, van den Berg, Wim B., van Lent, Peter L. E. M.

“…Objective S100A8 and S100A9 are two Ca2+ binding proteins classified as damage‐associated molecular patterns or alarmins that are found in high amounts in the…”
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IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology by van Dalen, Stephanie C M, Blom, Arjen B, Walgreen, Birgitte, Slöetjes, Annet W, Helsen, Monique M A, Geven, Edwin J W, Ter Huurne, Menno, Vogl, Thomas, Roth, Johannes, van de Loo, Fons A J, Koenders, Marije I, Casteilla, Louis, van der Kraan, Peter M, van den Bosch, Martijn H J, van Lent, Peter L E M

“…Injection of adipose-derived mesenchymal stromal cells (ASCs) into murine knee joints after induction of inflammatory collagenase-induced osteoarthritis (CiOA)…”
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Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy by van Lent, Peter L E M, Krijger, Gerard C, Hofkens, Wouter, Nievaart, Victor A, Sloetjes, Annet W, Moss, Ray L, Koning, Gerben A, van den Berg, Wim B

“…To investigate whether macrophages in the synovial lining can be selectively eliminated by local administration of an improved boron-10 ((10)B) containing…”
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Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy by van Lent, Peter L. E. M., Krijger, Gerard C., Hofkens, Wouter, Nievaart, Victor A., Sloetjes, Annet W., Moss, Ray L., Koning, Gerben A., van den Berg, Wim B.

“…Objective: To investigate whether macrophages in the synovial lining can be selectively eliminated by local administration of an improved boron-10 (10B)…”
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Nox2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis by Kruisbergen, Nik N. L., Di Ceglie, Irene, van Gemert, Yvonne, Walgreen, Birgitte, Helsen, Monique M. A., Slöetjes, Annet W., Koenders, Marije I., van de Loo, Fons A. J., Roth, Johannes, Vogl, Thomas, van der Kraan, Peter M., Blom, Arjen B., van Lent, Peter L. E. M., van den Bosch, Martijn H. J.

“…Osteoarthritis (OA) is a destructive disease of the joint with age and obesity being its most important risk factors. Around 50% of OA patients suffer from…”
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544 - S100A8/A9 DRIVES MONOCYTES TOWARDS M2-LIKE MACROPHAGE DIFFERENTIATION AND ASSOCIATES WITH M2-LIKE MACROPHAGES IN OSTEOARTHRITIC SYNOVIUM by Kooten, Nienke van, Blom, Arjen, Manen, Iris Teunissen van, Theeuwes, Wessel, Roth, Johannes, Gorris, Mark, Walgreen, Birgitte, Sloetjes, Annet, Helsen, Monique, Vitters, Elly, Lent, Peter van, Koëter, Sander, Kraan, Peter van der, Vogl, Thomas, Bosch, Martijn van den

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S100A8/A9 DRIVES MONOCYTES TOWARDS M2-LIKE MACROPHAGE DIFFERENTIATION AND ASSOCIATES WITH M2-LIKE MACROPHAGES IN OSTEOARTHRITIC SYNOVIUM by Kooten, Nienke van, Blom, Arjen, Manen, Iris Teunissen van, Theeuwes, Wessel, Roth, Johannes, Gorris, Mark, Walgreen, Birgitte, Sloetjes, Annet, Helsen, Monique, Vitters, Elly, Lent, Peter van, Koëter, Sander, Kraan, Peter van der, Vogl, Thomas, Bosch, Martijn van den

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Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation by Nabbe, Karin C A M, van Lent, Peter L E M, Holthuysen, Astrid E M, Sloëtjes, Annet W, Koch, Alisa E, Radstake, Timothy R D J, van den Berg, Wim B

“…During immune-complex-mediated arthritis (ICA), severe cartilage destruction is mediated by Fcgamma receptors (FcgammaRs) (mainly FcgammaRI), cytokines (e.g…”
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S100A8/A9 increases the mobilization of pro-inflammatory Ly6C high monocytes to the synovium during experimental osteoarthritis by Cremers, Niels A J, van den Bosch, Martijn H J, van Dalen, Stephanie, Di Ceglie, Irene, Ascone, Giuliana, van de Loo, Fons, Koenders, Marije, van der Kraan, Peter, Sloetjes, Annet, Vogl, Thomas, Roth, Johannes, Geven, Edwin J W, Blom, Arjen B, van Lent, Peter L E M

“…Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are…”
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The Inhibitory Receptor FcγRII Reduces Joint Inflammation and Destruction in Experimental Immune Complex-Mediated Arthritides Not Only by Inhibition of FcγRI/III but Also by Efficient Clearance and Endocytosis of Immune Complexes by van Lent, Peter, Nabbe, Karin C., Boross, Peter, Blom, Arjen B., Roth, Johannes, Holthuysen, Astrid, Sloetjes, Annet, Verbeek, Sjef, van den Berg, Wim

“…Studies of FcγRII−/− mice identified the inhibitory function of this receptor in joint inflammation and cartilage destruction induced with immune complexes…”
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Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis by Van Lent, Peter L.E.M., Nabbe, Karin, Blom, Arjen B., Holthuysen, Astrid E.M., Sloetjes, Annet, Van De Putte, Leo B.A., Verbeek, Sjef, Van Den Berg, Wim B.

“…IgG-containing immune complexes, which are found in most RA joints, communicate with hematopoietic cells using three classes of Fc receptors(FcγRI, -II, -III)…”
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