Search Results - "Sloan, Kenneth B."

Design for optimized topical delivery : Prodrugs and a paradigm change by SLOAN, Kenneth B, WASDO, Scott C, RAUTIO, Jarkko

“…In theory, topical delivery has substantial potential to treat local and some systemic disease states more effectively than systemic delivery. Unfortunately…”
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Imaging the Prodrug-to-Drug Transformation of a 5-Fluorouracil Derivative in Skin by Confocal Raman Microscopy by Zhang, Guojin, Moore, David J., Sloan, Kenneth B., Flach, Carol R., Mendelsohn, Richard

“…The widespread adoption of transdermal drug delivery has been limited by the barrier properties of the outermost layer of the epidermis, the stratum corneum…”
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Prodrugs – Recent approvals and a glimpse of the pipeline by Rautio, Jarkko, Kärkkäinen, Jussi, Sloan, Kenneth B.

“…Prodrugs offer a versatile strategy to overcome flaws of viable drug candidates or clinically approved drugs. However, the strategic importance of prodrugs in…”
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2-O-Acyl-3-O-(1-acyloxyalkyl) Prodrugs of 5,6-Isopropylidene-l-Ascorbic Acid and l-Ascorbic Acid: Antioxidant Activity and Ability to Permeate Silicone Membranes by Thiele, Nikki A, McGowan, Jennifer, Sloan, Kenneth B

“…2-O-Acyl-3-O-(1-acyloxyalkyl) prodrug derivatives, 15, of 5,6-isopropylidene-l-ascorbic acid, VCA, and l-ascorbic acid, VC, have been characterized by…”
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The Flux of Phenolic Compounds through Silicone Membranes by Prybylski, John, Sloan, Kenneth B

“…Phenols as a class of molecules have been reported to exhibit higher log maximum fluxes through human stratum corneum, SC, from water, log JMHAQ, than other…”
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A surrogate for topical delivery in human skin: silicone membranes by Sloan, Kenneth B, Synovec, Jennifer, Ketha, Hemamalini

“…We have identified, for any surrogate membrane and human skin in vitro, the maximum flux through the membrane (output) should be measured if a correlation…”
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Polyethylene Prodrugs Using Precisely Placed Pharmaceutical Agents by Leonard, James K., Turek, Diane, Sloan, Kenneth B., Wagener, Kenneth B.

“…Polyethylene‐based polymeric prodrugs have been prepared by acyclic diene metathesis (ADMET) polymerization; this condensation type, step growth…”
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The Flux of Select NSAIDs through Silicone Membranes from Mineral Oil by Mertz, Paul S, Sloan, Kenneth B

“…Here we report the experimental log maximum fluxes of n = 9 non-steroidal anti-inflammatory drugs (NSAID) through silicone membranes from the lipid mineral oil…”
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Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug by Thiele, Nikki A., Kärkkäinen, Jussi, Sloan, Kenneth B., Rautio, Jarkko, Huttunen, Kristiina M.

“…[Display omitted] •Drugs can be targeted into the brain via l-type amino acid transporter 1 (LAT1).•LAT1-utilizing prodrug of dopamine (dopa-CBT) is reported…”
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Regioselective synthesis of 2-O-acyl-3-O-(1-acyloxyalkyl) prodrugs of 5,6-isopropylidene-l-ascorbic acid by Prybylski, John, Thiele, Nikki A., Sloan, Kenneth B.

“…[Display omitted] •Regioselective 2-O-acylation of 5,6-isopropylidene-l-ascorbic acid.•3-O-soft alkyl derivatives of 5,6-isopropylidene-l-ascorbic…”
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Novel double prodrugs of the iron chelator N,N′-bis(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid (HBED): Synthesis, characterization, and investigation of activation by chemical hydrolysis and oxidation by Thiele, Nikki A., Abboud, Khalil A., Sloan, Kenneth B.

“…The development of iron chelators suitable for the chronic treatment of diseases where iron accumulation and subsequent oxidative stress are implicated in…”
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A Double Prodrug with Improved Membrane Permeability over the Parent Chelator HBED Provides Superior Cytoprotection against Hydrogen Peroxide by Thiele, Nikki A., Sloan, Kenneth B.

“…The clinical use of N,N′‐bis(2‐hydroxybenzyl)ethylenediamine‐N,N′‐diacetic acid (HBED) has been hindered by its lack of bioavailability. N,N′‐bis(2‐boronic…”
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The effect of lipid and aqueous solubilities on flux of nicotinic acid esters from water through silicone membrane by Synovec, Jennifer, Wasdo, Scott C., Sloan, Kenneth B.

“…Objective: The maximum fluxes (JM) of nicotinic acid esters (NAE) across silicone membranes from water (JMPAQ) have been measured to determine how well they…”
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Flux through silicone and human skin fitted to a series/parallel model by Prybylski, John, Sloan, Kenneth B

“…Recent reports of the good correlation between maximum flux through human skin in vitro from water, JMHAQ, and maximum flux through silicone from water, JMPAQ,…”
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Prodrugs of Theophylline Incorporating Ethyleneoxy Groups in the Promoiety: Synthesis, Characterization, and Transdermal Delivery by Majumdar, Susruta, Mueller-Spaeth, Maren, Sloan, Kenneth B.

“…Two different types of derivatives of theophylline (Th-H) incorporating ethyleneoxy groups into the promoiety have been synthesized. One is a soft alkyl type…”
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Designing for topical delivery: Prodrugs can make the difference by Sloan, Kenneth B., Wasdo, Scott

“…It has been shown for homologous series of prodrugs that those members who were the more water soluble ones gave the greatest enhancement in topical delivery…”
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Evaluation of alkyloxycarbonyloxymethyl (AOCOM) ethers as novel prodrugs of phenols for topical delivery: AOCOM prodrugs of acetaminophen by Thomas, Joshua D., Sloan, Kenneth B.

“…The maximum fluxes of a series of alkyloxycarbonyloxymethyl (AOCOM) ethers of acetaminophen (APAP) through hairless mouse skin from isopropyl myristate, IPM (…”
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Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs by Majumdar, Susruta, Sloan, Kenneth B.

“…The ability of N-alkyl-N-alkyloxycarbonylaminomethyl promoiety to act as soft alkylating agent and its influence in increasing membrane permeation for phenols,…”
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In vitro evaluation of alkylcarbonyloxymethyl (ACOM) ethers as novel prodrugs of phenols for topical delivery: ACOM prodrugs of acetaminophen by Thomas, Joshua D., Sloan, Kenneth B.

“…The fluxes ( J IPM) of a series of alkylcarbonyloxymethyl (ACOM) ethers of acetaminophen (APAP) were measured through hairless mouse skin from suspensions of…”
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Fit of fluxes of sunscreens and other compounds from propylene glycol:water (30:70) through human skin and silicone membrane to the Roberts-Sloan equation: the effect of polar vehicle (or water) solubility by Sloan, Kenneth B, Devarajan-Ketha, Hemamalini, Synovec, Jennifer, Majumdar, Susruta

“…It would be useful to develop a surrogate for animal skin, which could be use to predict flux through human skin. The fluxes (and physicochemical properties)…”
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