Search Results - "Sloan, Heather L."

Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient by Chapuis, Aude G, Lee, Sylvia M, Thompson, John A, Roberts, Ilana M, Margolin, Kim A, Bhatia, Shailender, Sloan, Heather L, Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D, Greenberg, Philip D, Yee, Cassian

“…Adoptive transfer of peripheral blood-derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky…”
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T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression by Chapuis, Aude G, Roberts, Ilana M, Thompson, John A, Margolin, Kim A, Bhatia, Shailender, Lee, Sylvia M, Sloan, Heather L, Lai, Ivy P, Farrar, Erik A, Wagener, Felecia, Shibuya, Kendall C, Cao, Jianhong, Wolchok, Jedd D, Greenberg, Philip D, Yee, Cassian

“…Purpose Peripheral blood-derived antigen-specific cytotoxic T cells (CTLs) provide a readily available source of effector cells that can be administered with…”
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Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I by Chapuis, Aude G, Afanasiev, Olga K, Iyer, Jayasri G, Paulson, Kelly G, Parvathaneni, Upendra, Hwang, Joo Ha, Lai, Ivy, Roberts, Ilana M, Sloan, Heather L, Bhatia, Shailender, Shibuya, Kendall C, Gooley, Ted, Desmarais, Cindy, Koelle, David M, Yee, Cassian, Nghiem, Paul

“…Merkel cell carcinoma (MCC) is an aggressive skin cancer that typically requires the persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins…”
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Abstract PR11: Enhanced in vivo persistence and therapeutic activity of combined transferred polyclonal melanoma-reactive CTL generated in presence of IL-21 and anti-CTLA4 by Chapuis, Aude G., Thompson, John A., Margolin, Kim A., Byrd, David, Bhatia, Shailender, Lee, Sylvia M., Lai, Ivy P., Roberts, Ilana M., Sloan, Heather L., Greenberg, Philip D., Yee, Cassian

“…Monotherapy with a blocking human anti-CTLA4 mAb achieves disease control in 20-28% of patients (pts), but failure to benefit in the remaining patients may…”
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