Search Results - "Slinkin, M A"

Terminal-modified polylysine-based chelating polymers: highly efficient coupling to antibody with minimal loss in immunoreactivity by Slinkin, M. A, Klibanov, A. L, Torchilin, V. P

“…A method is suggested for the preparation of chelating polymers containing a single terminal reactive group capable of interaction with proteins. These…”
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Gamma Imaging with Negatively Charge-Modified Monoclonal Antibody: Modification with Synthetic Polymers by Khaw, Ban-An, Klibanov, Alexander, O'Donnell, Sean M, Saito, Tomiyoshi, Nossiff, Naseem, Slinkin, Mikhail A, Newell, John B, Strauss, H. William, Torchilin, Vladimir P

“…Antimyosin Fab has been modified to carry highly negatively charged synthetic polymers containing DTPAs (DTPA-PL) as chelating agents, of starting molecular…”
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Endotoxin Reduces Specific Pulmonary Uptake of Radiolabeled Monoclonal Antibody to Angiotensin-Converting Enzyme by Muzykantov, Vladimir R, Puchnina, Elena A, Atochina, Elena N, Hiemish, Holger, Slinkin, Mikhail A, Meertsuk, Felix E, Danilov, Sergei M

“…The biodistribution of radiolabeled monoclonal antibody (Mab) to angiotensin-converting enzyme (ACE) was examined in normal and endotoxin-treated rats…”
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Biodistribution of anti-CEA F(ab')2 fragments conjugated with chelating polymers: influence of conjugate electron charge on tumor uptake and blood clearance by Slinkin, M A, Curtet, C, Faivre-Chauvet, A, Sai-Maurel, C, Gestin, J F, Torchilin, V P, Chatal, J F

“…F(ab')2 fragments of anti-carcinoembryonic antigen (CEA) monoclonal antibody (mAb) were modified with three chain-terminal polylysine-based chelating polymers…”
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Site-specific conjugation of chain-terminal chelating polymers to Fab' fragments of anti-CEA mAb: Effect of linkage type and polymer size on conjugate biodistribution in nude mice bearing human colorectal carcinoma by Slinkin, M. A, Curtet, C, Sai-Maurel, C, Gestin, J. F, Torchilin, V. P, Chatal, J. F

“…Polylysine-based chelating polymers were used for site-specific modification of anti-CEA mAb Fab' fragments via their SH group distal to the antigen-binding…”
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Succinylated polylysine as a possible link between an antibody molecule and deferoxamine by Slinkin, M. A, Klibanov, A. L, Khaw, B. A, Torchilin, V. P

“…Modification of antibodies with chelating polymers may be helpful for radioimmunoimaging, radioimmunotherapy, and NMR tomography. Succinylated polylysine was…”
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Radioimmunoimaging of lung vessels: an approach using indium-111-labeled monoclonal antibody to angiotensin-converting enzyme by Danilov, S M, Martynov, A V, Klibanov, A L, Slinkin, M A, Sakharov IYu, Malov, A G, Sergienko, V B, Vedernikov AYu, Muzykantov, V R, Torchilin, V P

“…A murine monoclonal antibody against human angiotensin-converting enzyme was radiolabeled with 111In via diethylenetriaminepentaacetic acid without substantial…”
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Blood Clearance of Radiolabeled Antibody: Enhancement by Lactosamination and Treatment with Biotin-Avidin or Anti-Mouse IgG Antibodies by Klibanov, Alexander L, Martynov, Andrei V, Slinkin, Mikhail A, Sakharov, Ivan Yu, Smirnov, Mikhail D, Muzykantov, Vladimir R, Danilov, Sergei M, Torchilin, Vladimir P

“…Methods of rapid blood clearance of 111In-labeled mouse monoclonal antibody 9B9 against angiotensin-converting enzyme were studied. Indium-111-9B9 is…”
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Lentivirus transduction of bone marrow hemopoietic precursor cells with Lin-c-kit+ phenotype ex vivo using a genetic construct containing green fluorescent protein gene by Radyukhina, N V, Rutkevich, P N, Aref'yeva, T I, Gurskaya, T Kh, Rybalkin, I N, Shevelyov, A Ya, Slinkin, M A, Vlasik, T N, Il'yinskaya, O P, Tararak, E M

“…We developed a technology of labeling bone marrow precursor cells with the Lin-c-kit+ phenotype in culture by green fluorescent protein gene using a lentivirus…”
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Targeting of macromolecular carriers and liposomes by antibodies to myosin heavy chain by Klibanov, A L, Khaw, B A, Nossiff, N, O'Donnell, S M, Huang, L, Slinkin, M A, Torchilin, V P

“…Macromolecular carriers and liposomes were covalently coupled to monoclonal antibodies against cardiac myosin heavy chain. Deferoxamine-modified polymers bound…”
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P3690Plasma levels of cardiac-specific micro-RNA mir-1 and mir-133a differ in patients with acute myocardial infarction and takotsubo cardiomyopathy by Novosadov, V, Vlasik, T N, Ruda, M Y A, Pevsner, D V, Rybalkin, I N, Titov, S E, Peklo, M M, Lipatova, L N, Slinkin, M A, Ivanov, M K

“…Abstract Background Takotsubo cardiomyopathy (TTC) is an acute, life-threatening condition which is typically induced by stress and manifested by chest pain…”
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Monoclonal antibody modification with chelate-linked high-molecular-weight polymers: major increases in polyvalent cation binding without loss of antigen binding by Torchilin, V P, Klibanov, A L, Nossiff, N D, Slinkin, M A, Strauss, H W, Haber, E, Smirnov, V N, Khaw, B A

“…Polyethyleneimine or polylysines of differing molecular sizes were substituted with either EDTA or DTPA and then with succinic acid groups. These polymers were…”
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Modification of monoclonal antibodies by polymers possessing chelating properties by Torchilin, V P, Khaw, B A, Klibanov, A L, Slinkin, M A, Haber, E

“…Monoclonal antibodies to heavy chains of the heart myosin were chemically modified by chelate polymers containing EDTA or DTPA residues. The modification…”
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Conjugation of monoclonal antibodies 5B4D6 immobilized on immunosorbent with chelating polymer by Mukhamedova, N. M., Slinkin, M. A.

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Conjugation of proteins with chelating polymers via water-soluble carbodiimide and N-hydroxysulfosuccinimide by KLIBANOV, A. L, SLINKIN, M. A, TORCHILIN, V. P

“…Water-soluble chelating polymers (CP) based on polylysine and diethylene-triaminepentaacetic acid (DTPA) have been prepared. The effect of the number of…”
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Chemical modification of immunoglobulins to accelerate their clearance from the blood stream during radioimmunodiagnosis by Mukhamedova, N. M., Obukhov, S. K., Slinkin, M. A., Klibanov, A. L., Torchilin, V. P.

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Triple interpolyelectrolyte complexes DNA-polycation-polyanion: a new approach to optimization of mixtures for transfection in eukaryotic cells by Slinkin, M A, Shevelev, A Ia

“…A new approach to optimization of mixtures for the condensation and introduction of plasmid DNA into eukaryotic cells is proposed, which is based on the…”
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The conjugation of preliminarily immunosorbent-immobilized 5B4D6 monoclonal antibodies with a chelating polymer by Mukhamedova, N M, Slinkin, M A

“…A study has been performed to investigate the change in antigen-binding capacity of antibodies as a result of their interaction with chelating agents, and…”
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Lentivirus transduction of bone marrow hemopoietic precursor cells with Lin-c-kit super(+) phenotype Ex Vivo using a genetic construct containing green fluorescent protein gene by Radyukhina, N V, Rutkevich, P N, Aref'yeva, TI, Gurskaya, TKh, Rybalkin, IN, Shevelyov, AYa, Slinkin, MA, Vlasik, T N, Il'yinskaya, O P, Tararak, E M

“…We developed a technology of labeling bone marrow precursor cells with the Lin super(-)c-kit super(+) phenotype in culture by green fluorescent protein gene…”
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The chemical modification of immunoglobulins for accelerating their elimination from the blood flow during radioimmunodiagnosis by Mukhamedova, N M, Obukhov, S K, Slinkin, M A, Klibanov, A L, Torchilin, V P

“…Immunoglobulins were modified by diethylenetriaminepentaacetic acid anhydride and sulfosuccinimidy 16-(biotinamido) hexanoate and were conjugated with modified…”
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