Search Results - "Slingerland, Annabelle S."

Mutations in the Glucokinase Gene of the Fetus Result in Reduced Placental Weight by Shields, Beverley M, Spyer, Gill, Slingerland, Annabelle S, Knight, Bridget A, Ellard, Sian, Clark, Penelope M, Hauguel-de Mouzon, Sylvie, Hattersley, Andrew T

“…OBJECTIVE:--In human pregnancy, placental weight is strongly associated with birth weight. It is uncertain whether there is regulation of the placenta by the…”
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Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Due to Kir6.2 Mutations by Pearson, Ewan R, Flechtner, Isabelle, Njølstad, Pål R, Malecki, Maciej T, Flanagan, Sarah E, Larkin, Brian, Ashcroft, Frances M, Klimes, Iwar, Codner, Ethel, Iotova, Violeta, Slingerland, Annabelle S, Shield, Julian, Robert, Jean-Jacques, Holst, Jens J, Clark, Penny M, Ellard, Sian, Søvik, Oddmund, Polak, Michel, Hattersley, Andrew T

“…The beta-cell ATP-sensitive potassium channel is made up of two subunits — SUR1 and Kir6.2 — and its normal function is critical to insulin secretion. This…”
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Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes by Gloyn, Anna L, Pearson, Ewan R, Antcliff, Jennifer F, Proks, Peter, Bruining, G. Jan, Slingerland, Annabelle S, Howard, Neville, Srinivasan, Shubha, Silva, José M.C.L, Molnes, Janne, Edghill, Emma L, Frayling, Timothy M, Temple, I. Karen, Mackay, Deborah, Shield, Julian P.H, Sumnik, Zdenek, van Rhijn, Adrian, Wales, Jerry K.H, Clark, Penelope, Gorman, Shaun, Aisenberg, Javier, Ellard, Sian, Njølstad, Pål R, Ashcroft, Frances M, Hattersley, Andrew T

“…This study shows that some patients with permanent neonatal diabetes have an activating mutation in the gene encoding Kir6.2, a subunit of the ATP-sensitive…”
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Stratified Patient-Centered Care in Type 2 Diabetes: A cluster-randomized, controlled clinical trial of effectiveness and cost-effectiveness by SLINGERLAND, Annabelle S, HERMAN, William H, REDEKOP, William K, DIJKSTRA, Rob F, WOUTER JUKEMA, J, NIESSEN, Louis W

“…Diabetes treatment should be effective and cost-effective. HbA1c-associated complications are costly. Would patient-centered care be more (cost-) effective if…”
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Monogenic diabetes in children and young adults: Challenges for researcher, clinician and patient by Slingerland, Annabelle S

“…Monogenic diabetes results from one or more mutations in a single gene which might hence be rare but has great impact leading to diabetes at a very young age…”
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Aging, Retirement, and Changes in Physical Activity: Prospective Cohort Findings from the GLOBE Study by Slingerland, Annabelle S., van Lenthe, Frank J., Jukema, J. Wouter, Kamphuis, Carlijn B. M., Looman, Caspar, Giskes, Katrina, Huisman, Martijn, Narayan, K. M. Venkat, Mackenbach, Johan P., Brug, Johannes

“…There is increased recognition that determinants of health should be investigated in a life-course perspective. Retirement is a major transition in the life…”
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Mutations in the Kir6.2 subunit of the KATP channel and permanent neonatal diabetes: new insights and new treatment by Slingerland, Annabelle S, Hattersley, Andrew T

“…Permanent neonatal diabetes (PNDM) is diagnosed in the first three months of life and is a major management problem as patients require lifelong insulin…”
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Activating Mutations in the Gene Encoding Kir6.2 Alter Fetal and Postnatal Growth and Also Cause Neonatal Diabetes by Slingerland, Annabelle S., Hattersley, Andrew T.

“…Context: Birth weight is a bioassay for fetal insulin secretion because altered insulin secretion in utero alters insulin-mediated growth. Activating mutations…”
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PREVALENCE AND INCIDENCE OF A NEWLY DEFINED TYPE OF DIABETES IN CHILDREN, ADOLESCENTS, AND ADULTS IN THE LARGEST INTERNATIONAL SERIES TO DATE by Slingerland, Annabelle S., Hattersley, Andrew

“…INTRODUCTION: Recently, interest in “neonatal” diabetes has increased because patients could stop taking insulin and improve glycemic control and associated…”
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Then and now: hypes and hopes of regenerative medicine by Slingerland, Annabelle S, Smits, Anthal I.P.M, Bouten, Carlijn V.C

“…[...]the development of engineered tissues-on-chips for the discovery and screening of drugs reduces the need for animal studies or large-scale clinical trials…”
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Stratified Patient-Centered Care in Type 2 Diabetes by Slingerland, Annabelle S., Herman, William H., Redekop, William K., Dijkstra, Rob F., Jukema, J. Wouter, Niessen, Louis W.

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THE AUTHORS REPLY by Slingerland, Annabelle S, van Lenthe, Frank J, Jukema, J Wouter, Kamphuis, Carlijn B M, Looman, Caspar, Giskes, Kathrina, Huisman, Martijn, Narayan, K M Venkat, Mackenbach, Johan P, Brug, Johannes

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THE AUTHORS REPLY by Slingerland, Annabelle S., van Lenthe, Frank J., Jukema, J. Wouter, Kamphuis, Carlijn B. M., Looman, Caspar, Giskes, Kathrina, Huisman, Martijn, Narayan, K. M. Venkat, Mackenbach, Johan P., Brug, Johannes

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THE AUTHORS REPLY by Slingerland, Annabelle S., van Lenthe, Frank J., Jukema, J. Wouter, Kamphuis, Carlijn B. M., Looman, Caspar, Giskes, Kathrina, Huisman, Martijn, Narayan, K. M. Venkat, Mackenbach, Johan P., Brug, Johannes

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