Search Results - "Slezak, Anna J."

Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds by Lauterbach, Abigail L., Wallace, Rachel P., Alpar, Aaron T., Refvik, Kirsten C., Reda, Joseph W., Ishihara, Ako, Beckman, Taryn N., Slezak, Anna J., Mizukami, Yukari, Mansurov, Aslan, Gomes, Suzana, Ishihara, Jun, Hubbell, Jeffrey A.

“…Non-healing wounds have a negative impact on quality of life and account for many cases of amputation and even early death among patients. Diabetic patients…”
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Author Correction: Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds by Lauterbach, Abigail L., Wallace, Rachel P., Alpar, Aaron T., Refvik, Kirsten C., Reda, Joseph W., Ishihara, Ako, Beckman, Taryn N., Slezak, Anna J., Mizukami, Yukari, Mansurov, Aslan, Gomes, Suzana, Ishihara, Jun, Hubbell, Jeffrey A.

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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker by Mansurov, Aslan, Hosseinchi, Peyman, Chang, Kevin, Lauterbach, Abigail L., Gray, Laura T., Alpar, Aaron T., Budina, Erica, Slezak, Anna J., Kang, Seounghun, Cao, Shijie, Solanki, Ani, Gomes, Suzana, Williford, John-Michael, Swartz, Melody A., Mendoza, Juan L., Ishihara, Jun, Hubbell, Jeffrey A.

“…Immune-checkpoint inhibitors have shown modest efficacy against immunologically ‘cold’ tumours. Interleukin-12 (IL-12)—a cytokine that promotes the recruitment…”
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Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics by Wallace, Rachel P, Refvik, Kirsten C, Antane, Jennifer T, Brünggel, Kym, Tremain, Andrew C, Raczy, Michal R, Alpar, Aaron T, Nguyen, Mindy, Solanki, Ani, Slezak, Anna J, Watkins, Elyse A, Lauterbach, Abigail L, Cao, Shijie, Wilson, D Scott, Hubbell, Jeffrey A

“…Immunogenic biologics trigger an anti-drug antibody (ADA) response in patients that reduces efficacy and increases adverse reactions. Our laboratory has shown…”
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Mannose-Decorated Co-Polymer Facilitates Controlled Release of Butyrate to Accelerate Chronic Wound Healing by Lauterbach, Abigail L, Slezak, Anna J, Wang, Ruyi, Cao, Shijie, Raczy, Michal M, Watkins, Elyse A, Jimenez, Carlos J Medina, Hubbell, Jeffrey A

“…Butyrate is a key bacterial metabolite that plays an important and complex role in modulation of immunity and maintenance of epithelial barriers. Its…”
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Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses by Tremain, Andrew C., Wallace, Rachel P., Lorentz, Kristen M., Thornley, Thomas B., Antane, Jennifer T., Raczy, Michal R., Reda, Joseph W., Alpar, Aaron T., Slezak, Anna J., Watkins, Elyse A., Maulloo, Chitavi D., Budina, Erica, Solanki, Ani, Nguyen, Mindy, Bischoff, David J., Harrington, Jamie L., Mishra, Rabinarayan, Conley, Gregory P., Marlin, Romain, Dereuddre-Bosquet, Nathalie, Gallouët, Anne-Sophie, LeGrand, Roger, Wilson, D. Scott, Kontos, Stephan, Hubbell, Jeffrey A.

“…Inducing antigen-specific tolerance during an established immune response typically requires non-specific immunosuppressive signalling molecules. Hence,…”
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A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice by Cao, Shijie, Budina, Erica, Raczy, Michal M., Solanki, Ani, Nguyen, Mindy, Beckman, Taryn N., Reda, Joseph W., Hultgren, Kevin, Ang, Phillip S., Slezak, Anna J., Hesser, Lauren A., Alpar, Aaron T., Refvik, Kirsten C., Shores, Lucas S., Pillai, Ishita, Wallace, Rachel P., Dhar, Arjun, Watkins, Elyse A., Hubbell, Jeffrey A.

“…Butyrate—a metabolite produced by commensal bacteria—has been extensively studied for its immunomodulatory effects on immune cells, including regulatory T…”
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Cysteine-binding adjuvant enhances survival and promotes immune function in a murine model of acute myeloid leukemia by Slezak, Anna J., Chang, Kevin, Beckman, Taryn N., Refvik, Kirsten C., Alpar, Aaron T., Lauterbach, Abigail L., Solanki, Ani, Kwon, Jung Woo, Gomes, Suzana, Mansurov, Aslan, Hubbell, Jeffrey A.

“…•We present a novel immunotherapy platform for hematological cancers that exploits fundamental metabolic dysregulation of cancer cells.•Our multivalent,…”
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Glycosylation-modified antigens as a tolerance-inducing vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy by Cao, Shijie, Maulloo, Chitavi D, Raczy, Michal M, Sabados, Matthew, Slezak, Anna J, Nguyen, Mindy, Solanki, Ani, Wallace, Rachel P, Shim, Ha-Na, Wilson, D Scott, Hubbell, Jeffrey A

“…The only FDA-approved oral immunotherapy for a food allergy provides protection against accidental exposure to peanuts. However, this therapy often causes…”
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Tumor Cell-Surface Binding of Immune Stimulating Polymeric Glyco-Adjuvant via Cysteine-Reactive Pyridyl Disulfide Promotes Antitumor Immunity by Slezak, Anna J., Mansurov, Aslan, Raczy, Michal M., Chang, Kevin, Alpar, Aaron T., Lauterbach, Abigail L., Wallace, Rachel P., Weathered, Rachel K., Medellin, Jorge E.G., Battistella, Claudia, Gray, Laura T., Marchell, Tiffany M., Gomes, Suzana, Swartz, Melody A., Hubbell, Jeffrey A.

“…Immune stimulating agents like Toll-like receptor 7 (TLR7) agonists induce potent antitumor immunity but are limited in their therapeutic window due to…”
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Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity by Kang, Seounghun, Mansurov, Aslan, Kurtanich, Trevin, Chun, Hye Rin, Slezak, Anna J, Volpatti, Lisa R, Chang, Kevin, Wang, Thomas, Alpar, Aaron T, Refvik, Kirsten C, Hansen, O Isabella, Borjas, Gustavo J, Shim, Ha-Na, Hultgren, Kevin T, Gomes, Suzana, Solanki, Ani, Ishihara, Jun, Swartz, Melody A, Hubbell, Jeffrey A

“…Cancer immunotherapy is moving toward combination regimens with agents of complementary mechanisms of action to achieve more frequent and robust efficacy…”
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Delivery of butyrate to the lower gut by polymeric micelles prolongs survival of distal skin allografts by Sepulveda, Martin, Kwan, Montserrat, Chen, Luqiu, Cassano, Alexandra, Cao, Shijie, Wang, Ruyi, Slezak, Anna J., Hubbell, Jeffrey A., Nagler, Cathryn R., Alegre, Maria-Luisa

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