Search Results - "Sleight, J. A"

Prolonged sedation due to accumulation of conjugated metabolites of midazolam by Bauer, T M, Ritz, R, Haberthür, C, Ha, H R, Hunkeler, W, Sleight, A J, Scollo-Lavizzari, G, Haefeli, W E

“…Midazolam is a short-acting benzodiazepine routinely used in intensive-care medicine. Conjugates of its main metabolite, alpha-hydroxymidazolam, have been…”
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5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential by Martin, J R, Bös, M, Jenck, F, Moreau, J, Mutel, V, Sleight, A J, Wichmann, J, Andrews, J S, Berendsen, H H, Broekkamp, C L, Ruigt, G S, Köhler, C, Delft, A M

“…In vitro, (S)-2-(chloro-5-fluoro-indol-1-yl)-1-methylethylamine 1:1 C4H4O4 and (S)-2-(4,4,7-trimethyl-1,4-dihydro-indeno[1, 2-b]pyrrol-1-yl)-1-methylethylamine…”
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The movement history and fault rock evolution of a reactivated crustal-scale strike-slip fault; the Walls Boundary fault zone, Shetland by Watts, L. M, Holdsworth, R. E, Sleight, J. A, Strachan, R. A, Smith, S. A. F

“…The Walls Boundary Fault Zone is a crustal-scale strike-slip fault that cuts Precambrian-Caledonian basement terranes in Shetland and has been interpreted as…”
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Characterization of Ro 04‐6790 and Ro 63‐0563: potent and selective antagonists at human and rat 5‐HT6 receptors by Sleight, Andrew J, Boess, Frank G, Bös, Michael, Levet‐Trafit, Bernard, Riemer, Claus, Bourson, Anne

“…This study describes the in vitro characterization of two potent and selective 5‐HT6 receptor antagonists at the rat and human recombinant 5‐HT6 receptor. In…”
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Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides by Bourson, A, Borroni, E, Austin, R H, Monsma, Jr, F J, Sleight, A J

“…The purpose of the present study was to determine possible physiological functions of the 5-ht6 receptor using antisense oligonucleotides (AOs) in male rats…”
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Novel Agonists of 5HT2C Receptors. Synthesis and Biological Evaluation of Substituted 2-(Indol-1-yl)-1-methylethylamines and 2-(Indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved Therapeutics for Obsessive Compulsive Disorder by Bös, Michael, Jenck, François, Martin, James R, Moreau, Jean-Luc, Sleight, Andrew J, Wichmann, Jürgen, Widmer, Ulrich

“…The syntheses of a series of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines are reported. The binding…”
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Effects of the 5-HT1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis by SKINGLE, M, SLEIGHT, A. J, FENIUK, W

“…The involvement of 5-HT1D receptors in the regulation of 5-HT release in the guinea-pig brain was examined using the novel 5-HT1D receptor blocking drug…”
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Investigation of stretching behaviour induced by the selective 5‐HT6 receptor antagonist, Ro 04–6790, in rats by Bentley, Jane C, Bourson, Anne, Boess, Frank G, Fone, Kevin C F, Marsden, Charles A, Petit, Nadine, Sleight, Andrew J

“…The present study examined the effects of the selective 5‐HT6 receptor antagonist 4‐amino‐N‐(2, 6 bis‐methylamino‐pyrimidin‐4‐yl)‐benzene sulphonamide (Ro…”
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Involvement of 5‐HT6 receptors in nigro‐striatal function in rodents by Bourson, Anne, Boess, Frank G, Bös, Michael, Sleight, Andrew J

“…4‐Amino‐N‐(2,4 bis‐methylamino‐pyrimidin‐4‐yl) benzene sulphonamide (Ro 04‐6790) is a potent, selective and competitive antagonist for the 5‐HT6 receptor which…”
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Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells by Boess, F G, Monsma, Jr, F J, Carolo, C, Meyer, V, Rudler, A, Zwingelstein, C, Sleight, A J

“…We have stably expressed the rat 5-HT6 receptor in HEK293 cells at a density of > 2 pmol/mg protein, as determined in equilibrium binding studies with [3H]-LSD…”
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Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task by King, M V, Spicer, C H, Sleight, A J, Marsden, C A, Fone, K C F

“…Selective 5-ht(6) receptor antagonists like Ro 04-6790 prolong memory in many rodent preclinical paradigms, possibly by blocking tonic 5-HT-evoked GABA release…”
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Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht6 receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task by King, M. V., Spicer, C. H., Sleight, A. J., Marsden, C. A., Fone, K. C. F.

“…Rationale Selective 5-ht 6 receptor antagonists like Ro 04-6790 prolong memory in many rodent preclinical paradigms, possibly by blocking tonic 5-HT-evoked…”
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Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice by Bourson, A, Kapps, V, Zwingelstein, C, Rudler, A, Boess, F G, Sleight, A J

“…Audiogenic seizures can be induced in DBA/2J mice following intense auditory stimulation. A number of neurotransmitters, including 5-hydroxytryptamine (5-HT),…”
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Identification of Residues in Transmembrane Regions III and VI that Contribute to the Ligand Binding Site of the Serotonin 5‐HT6 Receptor by Boess, Frank G., Monsma, Frederick J., Sleight, Andrew J.

“…: We have examined the ligand binding site of the serotonin 5‐HT6 receptor using site‐directed mutagenesis. Replacing the highly conserved Asp106 in…”
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Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist : effects of apparent agonist affinities by SLEIGHT, A. J, STAM, N. J, MUTEL, V, VANDERHEYDEN, P. M. L

“…Previous work has shown that 5-hydroxytryptamine (5-HT)2A receptors can be radiolabelled with various radioligands, including partial agonists, such as…”
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In vivo evidence that 5-hydroxytryptamine (5-HT) neuronal firing and release are not necessarily correlated with 5-HT metabolism by Crespi, F, Garratt, J C, Sleight, A J, Marsden, C A

“…The relationship between 5-hydroxytryptamine release, metabolism and unit activity has been investigated in the anaesthetized rat. 5-Hydroxytryptamine release…”
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In vivo effects of sumatriptan (GR 43175) on extracellular levels of 5-HT in the guinea pig by Sleight, A J, Cervenka, A, Peroutka, S J

“…The effect of sumatriptan, a selective 5-HT1D receptor agent, on extracellular levels of 5-HT in the frontal cortex of the guinea pig was measured by…”
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Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment by Sleight, A J, Carolo, C, Petit, N, Zwingelstein, C, Bourson, A

“…Due to the high level of expression of mRNA for the 5-hydroxytrytamine (5-ht7) receptor in the hypothalamus and the high affinity of 5-HT for this receptor,…”
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Relationship between extracellular 5‐hydroxytryptamine and behaviour following monoamine oxidase inhibition and l‐tryptophan by Sleight, A.J., Marsden, C.A., Martin, K.F., Palfreyman, M.G.

“…1 The present study investigates the effects of selective and a non‐selective monoamine oxidase (MAO) inhibitors combined with l‐tryptophan on MAO‐A and ‐B…”
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Characterization of (R,S)‐5,7‐di‐tert‐butyl‐3‐hydroxy‐3‐trifluoromethyl‐3H‐benzofuran‐2‐one as a positive allosteric modulator of GABAB receptors by Malherbe, P, Masciadri, R, Norcross, R D, Knoflach, F, Kratzeisen, C, Zenner, M‐T, Kolb, Y, Marcuz, A, Huwyler, J, Nakagawa, T, Porter, R H P, Thomas, A W, Wettstein, J G, Sleight, A J, Spooren, W, Prinssen, E P

“…Background and purpose: As baclofen is active in patients with anxiety disorders, GABAB receptors have been implicated in the modulation of anxiety. To avoid…”
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