Search Results - "Sleeper, Meg M"

The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution by Ríos, Luis, Sleeper, Meg M., Danforth, Marietta D., Murphy, Hayley Weston, Kutinsky, Ilana, Rosas, Antonio, Bastir, Markus, Gómez-Cambronero, José, Sanjurjo, Ricardo, Campens, Laurence, Rider, Oliver, Pastor, Francisco

“…Humans have a larger energy budget than great apes, allowing the combination of the metabolically expensive traits that define our life history. This budget is…”
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Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat by Bish, Lawrence T, Morine, Kevin, Sleeper, Meg M, Sanmiguel, Julio, Wu, Di, Gao, Guangping, Wilson, James M, Sweeney, H Lee

“…Heart disease is the leading cause of morbidity and mortality. Cardiac gene transfer may serve as a novel therapeutic approach. This investigation was…”
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Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse by Selsby, Joshua T, Acosta, Pedro, Sleeper, Meg M, Barton, Elisabeth R, Sweeney, H Lee

“…Dystrophin-deficient muscles suffer from free radical injury, mitochondrial dysfunction, apoptosis, and inflammation, among other pathologies that contribute…”
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Long-term Restoration of Cardiac Dystrophin Expression in Golden Retriever Muscular Dystrophy Following rAAV6-mediated Exon Skipping by Bish, Lawrence T, Sleeper, Meg M, Forbes, Sean C, Wang, Bingjing, Reynolds, Caryn, Singletary, Gretchen E, Trafny, Dennis, Morine, Kevin J, Sanmiguel, Julio, Cecchini, Sylvain, Virag, Tamas, Vulin, Adeline, Beley, Cyriaque, Bogan, Janet, Wilson, James M, Vandenborne, Krista, Kornegay, Joe N, Walter, Glenn A, Kotin, Robert M, Garcia, Luis, Sweeney, H Lee

“…Although restoration of dystrophin expression via exon skipping in both cardiac and skeletal muscle has been successfully demonstrated in the mdx mouse,…”
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Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice by Morine, Kevin J, Bish, Lawrence T, Pendrak, Klara, Sleeper, Meg M, Barton, Elisabeth R, Sweeney, H Lee

“…Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and…”
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Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice by Bish, Lawrence T, Yarchoan, Mark, Sleeper, Meg M, Gazzara, Jeffrey A, Morine, Kevin J, Acosta, Pedro, Barton, Elisabeth R, Sweeney, H Lee

“…Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension…”
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Long-term Amelioration of Feline Mucopolysaccharidosis VI After AAV-mediated Liver Gene Transfer by Cotugno, Gabriella, Annunziata, Patrizia, Tessitore, Alessandra, O'Malley, Thomas, Capalbo, Anita, Faella, Armida, Bartolomeo, Rosa, O'Donnell, Patricia, Wang, Ping, Russo, Fabio, Sleeper, Meg M, Knox, Van W, Fernandez, Steven, Levanduski, Leah, Hopwood, John, De Leonibus, Elvira, Haskins, Mark, Auricchio, Alberto

“…Mucopolysaccharidosis VI (MPS VI) is caused by deficient arylsulfatase B (ARSB) activity resulting in lysosomal storage of glycosaminoglycans (GAGs). MPS VI is…”
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Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model by Bish, Lawrence T, Morine, Kevin J, Sleeper, Meg M, Sweeney, H Lee

“…Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to…”
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Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of duchenne muscular dystrophy by Morine, Kevin J., Bish, Lawrence T., Selsby, Joshua T., Gazzara, Jeffery A., Pendrak, Klara, Sleeper, Meg M., Barton, Elisabeth R., Lee, Se-Jin, Sweeney, H. Lee

“…Modulation of transforming growth factor‐β (TGF‐β) signaling to promote muscle growth holds tremendous promise for the muscular dystrophies and other disorders…”
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Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques by Gao, Guangping, Bish, Lawrence T, Sleeper, Meg M, Mu, Xin, Sun, Lan, Lou, You, Duan, Jiachuan, Hu, Chunyan, Wang, Li, Sweeney, H Lee

“…Heart disease is the leading cause of morbidity and mortality, and cardiac gene transfer has potential as a novel therapeutic approach. We previously…”
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Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage by Morine, Kevin J, Sleeper, Meg M, Barton, Elisabeth R, Sweeney, H Lee

“…Although the precise pathophysiological mechanism of muscle damage in dystrophin-deficient muscle remains disputed, calcium appears to be a critical mediator…”
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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines by Bish, Lawrence T, Sleeper, Meg M, Reynolds, Caryn, Gazzara, Jeffrey, Withnall, Elanor, Singletary, Gretchen E, Buchlis, George, Hui, Daniel, High, Katherine A, Gao, Guangping, Wilson, James M, Sweeney, H Lee

“…Derangements in calcium cycling have been described in failing hearts, and preclinical studies have suggested that therapies aimed at correcting this defect…”
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Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs by Bigg, Paul W., Baldo, Guilherme, Sleeper, Meg M., O'Donnell, Patricia A., Bai, Hanqing, Rokkam, Venkata R.P., Liu, Yuli, Wu, Susan, Giugliani, Roberto, Casal, Margret L., Haskins, Mark E., Ponder, Katherine P.

“…Mucopolysaccharidosis VII (MPS VII) is due to the deficient activity of β-glucuronidase (GUSB) and results in the accumulation of glycosaminoglycans (GAGs) in…”
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Canine bacterial endocarditis: a review by Peddle, Gordon, Sleeper, Meg M

“…Bacterial endocarditis is a disease of primarily middle-aged to older, large-breed dogs that is associated with high morbidity and mortality. It presents many…”
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Sudden cardiac death in 13 captive chimpanzees (Pan troglodytes) by Lammey, Michael L, Lee, D. Rick, Ely, John J, Sleeper, Meg M

“…Sudden cardiac death (SCD), presumed secondary to fatal arrhythmias, is a common cause of mortality in captive chimpanzees at the Alamogordo Primate Facility…”
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Status of Therapeutic Gene Transfer to Treat Cardiovascular Disease in Dogs and Cats by Sleeper, Meg M

“…Gene therapy is a procedure resulting in the transfer of a gene into an individual's cells to treat a disease. One goal of gene transfer is to express a…”
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Equine Cardiovascular Therapeutics by Sleeper, Meg M

“…Heart disease can be defined as any abnormality of the heart whether it is a cardiac dysrhythmia or structural heart disease, either congenital or acquired…”
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Monitoring great ape heart health through innovative electrocardiogram technology: Training methodologies and welfare implications by Cloutier Barbour, Christina, Danforth, Marietta D., Murphy, Hayley, Sleeper, Meg M., Kutinsky, Ilana

“…Assessing and treating cardiovascular disease (or heart disease) is a growing concern for institutions housing great apes, as it is a major cause of mortality…”
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Pharmacokinetics of furosemide after intravenous, oral and transdermal administration to cats by Sleeper, Meg M, O’Donnell, Patricia, Fitzgerald, Caitlin, Papich, Mark G

“…Objectives The aim of this study was to determine the pharmacokinetics of furosemide in cats following intravenous (IV), oral and transdermal administration…”
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Use of the vertebral heart scale for differentiation of cardiac and noncardiac causes of respiratory distress in cats: 67 cases (2002–2003) by Sleeper, Meg M, Roland, Risa, Drobatz, Kenneth J

“…Objective-To assess the effectiveness of the vertebral heart scale (VHS) system to differentiate congestive heart failure from other causes of dyspnea in cats…”
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