Search Results - "Sleeper, M."

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat by Bish, Lawrence T, Morine, Kevin, Sleeper, Meg M, Sanmiguel, Julio, Wu, Di, Gao, Guangping, Wilson, James M, Sweeney, H Lee

“…Heart disease is the leading cause of morbidity and mortality. Cardiac gene transfer may serve as a novel therapeutic approach. This investigation was…”
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The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution by Ríos, Luis, Sleeper, Meg M., Danforth, Marietta D., Murphy, Hayley Weston, Kutinsky, Ilana, Rosas, Antonio, Bastir, Markus, Gómez-Cambronero, José, Sanjurjo, Ricardo, Campens, Laurence, Rider, Oliver, Pastor, Francisco

“…Humans have a larger energy budget than great apes, allowing the combination of the metabolically expensive traits that define our life history. This budget is…”
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Distribution of density along magnetospheric field lines by Denton, R. E., Takahashi, K., Galkin, I. A., Nsumei, P. A., Huang, X., Reinisch, B. W., Anderson, R. R., Sleeper, M. K., Hughes, W. J.

“…This paper examines the field line distribution of magnetospheric electron density and mass density. The electron density distributions from IMAGE RPI active…”
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Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse by Selsby, Joshua T, Acosta, Pedro, Sleeper, Meg M, Barton, Elisabeth R, Sweeney, H Lee

“…Dystrophin-deficient muscles suffer from free radical injury, mitochondrial dysfunction, apoptosis, and inflammation, among other pathologies that contribute…”
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Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques by Gao, Guangping, Bish, Lawrence T, Sleeper, Meg M, Mu, Xin, Sun, Lan, Lou, You, Duan, Jiachuan, Hu, Chunyan, Wang, Li, Sweeney, H Lee

“…Heart disease is the leading cause of morbidity and mortality, and cardiac gene transfer has potential as a novel therapeutic approach. We previously…”
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Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice by Morine, Kevin J, Bish, Lawrence T, Pendrak, Klara, Sleeper, Meg M, Barton, Elisabeth R, Sweeney, H Lee

“…Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and…”
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Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage by Morine, Kevin J, Sleeper, Meg M, Barton, Elisabeth R, Sweeney, H Lee

“…Although the precise pathophysiological mechanism of muscle damage in dystrophin-deficient muscle remains disputed, calcium appears to be a critical mediator…”
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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines by Bish, Lawrence T, Sleeper, Meg M, Reynolds, Caryn, Gazzara, Jeffrey, Withnall, Elanor, Singletary, Gretchen E, Buchlis, George, Hui, Daniel, High, Katherine A, Gao, Guangping, Wilson, James M, Sweeney, H Lee

“…Derangements in calcium cycling have been described in failing hearts, and preclinical studies have suggested that therapies aimed at correcting this defect…”
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Long-term Restoration of Cardiac Dystrophin Expression in Golden Retriever Muscular Dystrophy Following rAAV6-mediated Exon Skipping by Bish, Lawrence T, Sleeper, Meg M, Forbes, Sean C, Wang, Bingjing, Reynolds, Caryn, Singletary, Gretchen E, Trafny, Dennis, Morine, Kevin J, Sanmiguel, Julio, Cecchini, Sylvain, Virag, Tamas, Vulin, Adeline, Beley, Cyriaque, Bogan, Janet, Wilson, James M, Vandenborne, Krista, Kornegay, Joe N, Walter, Glenn A, Kotin, Robert M, Garcia, Luis, Sweeney, H Lee

“…Although restoration of dystrophin expression via exon skipping in both cardiac and skeletal muscle has been successfully demonstrated in the mdx mouse,…”
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A review of the underlying genetics and emerging therapies for canine cardiomyopathies by Shen, L., Estrada, A.H., Meurs, K.M., Sleeper, M., Vulpe, C., Martyniuk, C.J., Pacak, C.A.

“…Cardiomyopathies such as dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy are common in large breed dogs and carry an overall poor…”
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Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin‐Deficient Hearts by Hammers, David W., Sleeper, Margaret M., Forbes, Sean C., Shima, Ai, Walter, Glenn A., Sweeney, H. Lee

“…Background Cardiomyopathy is a leading cause of mortality among Duchenne muscular dystrophy patients and lacks effective therapies. Phosphodiesterase type 5 is…”
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Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model by Bish, Lawrence T, Morine, Kevin J, Sleeper, Meg M, Sweeney, H Lee

“…Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to…”
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Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice by Bish, Lawrence T, Yarchoan, Mark, Sleeper, Meg M, Gazzara, Jeffrey A, Morine, Kevin J, Acosta, Pedro, Barton, Elisabeth R, Sweeney, H Lee

“…Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension…”
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Clinical Efficacy of Sildenafil in Treatment of Pulmonary Arterial Hypertension in Dogs by Brown, A.J, Davison, E, Sleeper, M.M

“…Background: Pulmonary arterial hypertension (PAH) in dogs carries a poor prognosis. Sildenafil increases exercise capacity and improves hemodynamics in people…”
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Long-term Amelioration of Feline Mucopolysaccharidosis VI After AAV-mediated Liver Gene Transfer by Cotugno, Gabriella, Annunziata, Patrizia, Tessitore, Alessandra, O'Malley, Thomas, Capalbo, Anita, Faella, Armida, Bartolomeo, Rosa, O'Donnell, Patricia, Wang, Ping, Russo, Fabio, Sleeper, Meg M, Knox, Van W, Fernandez, Steven, Levanduski, Leah, Hopwood, John, De Leonibus, Elvira, Haskins, Mark, Auricchio, Alberto

“…Mucopolysaccharidosis VI (MPS VI) is caused by deficient arylsulfatase B (ARSB) activity resulting in lysosomal storage of glycosaminoglycans (GAGs). MPS VI is…”
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Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of duchenne muscular dystrophy by Morine, Kevin J., Bish, Lawrence T., Selsby, Joshua T., Gazzara, Jeffery A., Pendrak, Klara, Sleeper, Meg M., Barton, Elisabeth R., Lee, Se-Jin, Sweeney, H. Lee

“…Modulation of transforming growth factor‐β (TGF‐β) signaling to promote muscle growth holds tremendous promise for the muscular dystrophies and other disorders…”
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Cardiac Magnetic Resonance in the Differentiation of Neoplastic and Nonneoplastic Pericardial Effusion by Boddy, K.N., Sleeper, M.M., Sammarco, C.D., Weisse, C., Ghods, S., Litt, H.I.

“…Background: Cardiac magnetic resonance (CMR) is the imaging modality of choice for cardiac tumors in people. Although neoplastic pericardial effusion (PE)…”
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Acupuncture and traditional Chinese veterinary medicine for treatment of a mare with rectal paralysis by Sleeper, M. M., Fishman, K., MacKay, R. J., Brown, M., Bauck, A. G., Xie, H.

“…Summary An 8‐year‐old Appaloosa mare with rectal paralysis due to a cosmetic ethanol ‘tail block’ was treated with traditional Chinese veterinary medicine…”
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Cardiac Troponin I in the Normal Dog and Cat by Sleeper, Margaret M., Clifford, Craig A., Laster, Larry L.

“…Cardiac troponin I (cTnl) has proven to be a highly specific and sensitive marker for myocardial cellular damage in many mammalian species. The structure of…”
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Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs by Bigg, Paul W., Baldo, Guilherme, Sleeper, Meg M., O'Donnell, Patricia A., Bai, Hanqing, Rokkam, Venkata R.P., Liu, Yuli, Wu, Susan, Giugliani, Roberto, Casal, Margret L., Haskins, Mark E., Ponder, Katherine P.

“…Mucopolysaccharidosis VII (MPS VII) is due to the deficient activity of β-glucuronidase (GUSB) and results in the accumulation of glycosaminoglycans (GAGs) in…”
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