Search Results - "Sleen, Yannick"

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40/Interleukin‐13 Receptor α2 Axis by Sleen, Yannick, Jiemy, William F., Pringle, Sarah, Geest, Kornelis S. M., Abdulahad, Wayel H., Sandovici, Maria, Brouwer, Elisabeth, Heeringa, Peter, Boots, Annemieke M. H.

“…Objective Macrophages mediate inflammation, angiogenesis, and tissue destruction in giant cell arteritis (GCA). Serum levels of the macrophage‐associated…”
Get full text

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis? by Geest, Kornelis S. M., Sandovici, Maria, Sleen, Yannick, Sanders, Jan‐Stephan, Bos, Nicolaas A., Abdulahad, Wayel H., Stegeman, Coen A., Heeringa, Peter, Rutgers, Abraham, Kallenberg, Cees G. M., Boots, Annemieke M. H., Brouwer, Elisabeth

“…Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium‐sized arteries. Ample evidence indicates that GCA is a heterogeneous disease…”
Get full text

Altered Plasma Levels and Tissue Expression of Fibroblast Activation Protein Alpha in Giant Cell Arteritis by Xu, Shuang, Jiemy, William F., Boots, Annemieke M. H., Arends, Suzanne, Sleen, Yannick, Nienhuis, Pieter H., Geest, Kornelis S. M., Heeringa, Peter, Brouwer, Elisabeth, Sandovici, Maria

“…Objective Giant cell arteritis (GCA) is characterized by granulomatous inflammation of the medium‐ and large‐sized arteries accompanied by remodeling of the…”
Get full text

Humoral SARS–CoV‐2 Vaccine Responses in Patients With Giant Cell Arteritis and Polymyalgia Rheumatica: Decay After Primary Vaccination and Effects of the Booster by Sleen, Yannick, Geest, Kornelis S. M., Buisman, Anne‐Marie, Sandovici, Maria, Baarle, Debbie, Brouwer, Elisabeth

“…Objective Vaccination remains essential in preventing morbidity of SARS–CoV‐2 infections. We previously showed that >10 mg/day of prednisolone and methotrexate…”
Get full text

Distinct macrophage phenotypes skewed by local granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis by Jiemy, William F, Sleen, Yannick, Geest, Kornelis SM, Berge, Hilde A, Abdulahad, Wayel H, Sandovici, Maria, Boots, Annemieke MH, Heeringa, Peter, Brouwer, Elisabeth

“…Objective To determine the presence and spatial distribution of different macrophage phenotypes, governed by granulocyte macrophage colony‐stimulating factor…”
Get full text

Biomarkers in the era of targeted therapy in giant cell arteritis and polymyalgia rheumatica: is it possible to replace acute-phase reactants? by Carvajal Alegria, Guillermo, Nicolas, Mathilde, van Sleen, Yannick

“…Research into giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) has become more important in the last few decades. Physicians are facing several…”
Get full text

Subclinical giant cell arteritis in new onset polymyalgia rheumatica A systematic review and meta-analysis of individual patient data by Hemmig, Andrea K., Gozzoli, Daniele, Werlen, Laura, Ewald, Hannah, Aschwanden, Markus, Blockmans, Daniel, Brouwer, Elisabeth, Buchanan, Russell R.C., Camellino, Dario, Campochiaro, Corrado, Cimmino, Marco A., Corominas, Hector, Gloy, Viktoria, Henckaerts, Liesbet, Kyburz, Diego, Moya-Alvarado, Patricia, Owen, Claire E., Stegert, Mihaela, Tomelleri, Alessandro, van Sleen, Yannick, Yamashita, Hiroyuki, Imfeld, Stephan, Berger, Christoph T., Hemkens, Lars G., Daikeler, Thomas

“…•More than a quarter of patients with PMR may have subclinical GCA at diagnosis.•Meta-analysis of a large patients’ data set could not identify a marker for…”
Get full text

Indication of Activated Senescence Pathways in the Temporal Arteries of Patients With Giant Cell Arteritis by Jiemy, William F, van Sleen, Yannick, Graver, Jacoba C, Pringle, Sarah, Brouwer, Elisabeth, van der Geest, K S M, Cornec, Divi, Boots, Annemieke M H, Sandovici, Maria

“…Giant cell arteritis (GCA) affects almost exclusively individuals above 50 years old, suggesting a role of aging-related changes such as cellular senescence in…”
Get full text

A randomized phase I/II safety and immunogenicity study of the Montanide-adjuvanted SARS-CoV-2 spike protein-RBD-Fc vaccine, AKS-452 by Feitsma, Eline A., Janssen, Yester F., Boersma, Hendrikus H., van Sleen, Yannick, van Baarle, Debbie, Alleva, David G., Lancaster, Thomas M., Sathiyaseelan, Thillainaygam, Murikipudi, Sylaja, Delpero, Andrea R., Scully, Melanie M., Ragupathy, Ramya, Kotha, Sravya, Haworth, Jeffrey R., Shah, Nishit J., Rao, Vidhya, Nagre, Shashikant, Ronca, Shannon E., Green, Freedom M., Aminetzah, Ari, Sollie, Frans, Kruijff, Schelto, Brom, Maarten, van Dam, Gooitzen M., Zion, Todd C.

“…Previous interim data from a phase I study of AKS-452, a subunit vaccine comprising an Fc fusion of the respiratory syndrome coronavirus 2 (SARS-CoV-2) spike…”
Get full text

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial by van der Heiden, Marieke, Shetty, Sudarshan, Bijvank, Elske, Beckers, Lisa, Cevirgel, Alper, van Sleen, Yannick, Tcherniaeva, Irina, Ollinger, Thierry, Burny, Wivine, van Binnendijk, Rob S., van Houten, Marianne A., Buisman, Anne-Marie, Rots, Nynke Y., van Beek, Josine, van Baarle, Debbie

“…Vaccine responsiveness is often reduced in older adults. Yet, our lack of understanding of low vaccine responsiveness hampers the development of effective…”
Get full text

Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis by Esen, Idil, Jiemy, William F, van Sleen, Yannick, Bijzet, Johan, de Jong, Daniel M, Nienhuis, Pieter H, Slart, Riemer H J A, Heeringa, Peter, Boots, Annemieke M H, Brouwer, Elisabeth

“…Abstract Objectives GCA is a large vessel vasculitis in which metabolically active immune cells play an important role. GCA diagnosis is based on CRP/ESR and…”
Get full text

Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica by van Sleen, Yannick, Graver, Jacoba C, Abdulahad, Wayel H, van der Geest, Kornelis S M, Boots, Annemieke M H, Sandovici, Maria, Brouwer, Elisabeth

“…Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory diseases requiring long-term glucocorticoid treatment. Limited data on dynamics in…”
Get full text

Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis by van Sleen, Yannick, Wang, Qi, van der Geest, Kornelis S. M., Westra, Johanna, Abdulahad, Wayel H., Heeringa, Peter, Boots, Annemieke M. H., Brouwer, Elisabeth

“…Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia…”
Get full text

Angiopoietin-2/-1 ratios and MMP-3 levels as an early warning sign for the presence of giant cell arteritis in patients with polymyalgia rheumatica by van Sleen, Yannick, Therkildsen, Philip, Nielsen, Berit Dalsgaard, van der Geest, Kornelis S M, Hansen, Ib, Heeringa, Peter, Posthumus, Marcel D, Sandovici, Maria, Toonen, Erik J M, Zijlstra, Jannik, Boots, Annemieke M H, Hauge, Ellen-Margrethe, Brouwer, Elisabeth

“…Diagnosing patients with giant cell arteritis (GCA) remains difficult. Due to its non-specific symptoms, it is challenging to identify GCA in patients…”
Get full text

Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica by Reitsema, Rosanne D., Hesselink, Bernd-Cornèl, Abdulahad, Wayel H., van der Geest, Kornelis S. M., Brouwer, Elisabeth, Heeringa, Peter, van Sleen, Yannick

“…BackgroundGiant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are overlapping inflammatory diseases. Antigen-presenting cells (APCs), including…”
Get full text

Evidence for increased interferon type I activity in CD8+ T cells in giant cell arteritis patients by van Nieuwland, Marieke, Esen, Idil, Reitsema, Rosanne D, Abdulahad, Wayel H, van Sleen, Yannick, Jiemy, William F, Sandovici, Maria, Brouwer, Elisabeth, van Bon, Lenny

“…Giant cell arteritis (GCA) is a vasculitis of the medium- and large-sized arteries. Interferon type I (IFN-I) is increasingly recognized as a key player in…”
Get full text

Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica by Reitsema, Rosanne D, Jiemy, William F, Wekema, Lieske, Boots, Annemieke M H, Heeringa, Peter, Huitema, Minke G, Abdulahad, Wayel H, van Sleen, Yannick, Sandovici, Maria, Roozendaal, Caroline, Diepstra, Arjan, Kwee, Thomas, Dasgupta, Bhaskar, Brouwer, Elisabeth, van der Geest, Kornelis S M

“…Although polymyalgia rheumatica (PMR) is a very common rheumatic inflammatory disease, current insight into the pathobiology of PMR is limited and largely…”
Get full text

Need and value of targeted immunosuppressive therapy in giant cell arteritis by Sandovici, Maria, van der Geest, Niels, van Sleen, Yannick, Brouwer, Elisabeth

“…Despite the heterogeneity of the giant cell arteritis (GCA) at the level of clinical manifestations and the cellular and molecular players involved in its…”
Get full text

mRNA-1273 vaccination induces polyfunctional memory CD4 and CD8 T cell responses in patients with solid cancers undergoing immunotherapy or/and chemotherapy by Gangaev, Anastasia, van Sleen, Yannick, Brandhorst, Nicole, Hoefakker, Kelly, Prajapati, Bimal, Singh, Amrita, Boerma, Annemarie, van der Heiden, Marieke, Oosting, Sjoukje F, van der Veldt, Astrid A M, Hiltermann, T Jeroen N, GeurtsvanKessel, Corine H, Dingemans, Anne-Marie C, Smit, Egbert F, de Vries, Elisabeth G E, Haanen, John B A G, Kvistborg, Pia, van Baarle, Debbie

“…Research has confirmed the safety and comparable seroconversion rates following SARS-CoV-2 vaccination in patients with solid cancers. However, the impact of…”
Get full text

Frailty is related to serum inflammageing markers: results from the VITAL study by van Sleen, Yannick, Shetty, Sudarshan A, van der Heiden, Marieke, Venema, Milou C. A, Gutiérrez-Melo, Nicolas, Toonen, Erik J. M, van Beek, Josine, Buisman, Anne-Marie, van Baarle, Debbie, Sauce, Delphine

“…Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty,…”
Get full text