Search Results - "Slayman, Carolyn W"

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor by Goldgof, Gregory M., Durrant, Jacob D., Ottilie, Sabine, Vigil, Edgar, Allen, Kenneth E., Gunawan, Felicia, Kostylev, Maxim, Henderson, Kiersten A., Yang, Jennifer, Schenken, Jake, LaMonte, Gregory M., Manary, Micah J., Murao, Ayako, Nachon, Marie, Murray, Rebecca, Prescott, Maximo, McNamara, Case W., Slayman, Carolyn W., Amaro, Rommie E., Suzuki, Yo, Winzeler, Elizabeth A.

“…The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase,…”
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Tandem Phosphorylation of Ser-911 and Thr-912 at the C Terminus of Yeast Plasma Membrane H+-ATPase Leads to Glucose-dependent Activation by Lecchi, Silvia, Nelson, Clark J., Allen, Kenneth E., Swaney, Danielle L., Thompson, Katie L., Coon, Joshua J., Sussman, Michael R., Slayman, Carolyn W.

“…In recent years there has been growing interest in the post-translational regulation of P-type ATPases by protein kinase-mediated phosphorylation. Pma1…”
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C-Terminal Truncations of the Saccharomyces cerevisiae PMA1 H+-ATPase Have Major Impacts on Protein Conformation, Trafficking, Quality Control, and Function by Mason, A Brett, Allen, Kenneth E, Slayman, Carolyn W

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies by Ottilie, Sabine, Goldgof, Gregory M., Cheung, Andrea L., Walker, Jennifer L., Vigil, Edgar, Allen, Kenneth E., Antonova-Koch, Yevgeniya, Slayman, Carolyn W., Suzuki, Yo, Durrant, Jacob D.

“…Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the…”
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Coordination of K+ Transporters in Neurospora: TRK1 Is Scarce and Constitutive, while HAK1 Is Abundant and Highly Regulated by Rivetta, Alberto, Allen, Kenneth E, Slayman, Carolyn W, Slayman, Clifford L

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effects of C-terminal Truncations on Trafficking of the Yeast Plasma Membrane H+-ATPase by Mason, A. Brett, Allen, Kenneth E., Slayman, Carolyn W.

“…Within the large family of P-type cation-transporting ATPases, members differ in the number of C-terminal transmembrane helices, ranging from two in…”
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Conformational Changes of Yeast Plasma Membrane H+-ATPase during Activation by Glucose:  Role of Threonine-912 in the Carboxy-Terminal Tail by Lecchi, Silvia, Allen, Kenneth E, Pardo, Juan Pablo, Mason, A. Brett, Slayman, Carolyn W

“…Yeast Pma1 H+-ATPase, which belongs to the P-type family of cation-transporting ATPases, is activated up to 10-fold by growth on glucose, and indirect evidence…”
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Role of transmembrane segment M8 in the biogenesis and function of yeast plasma-membrane H +-ATPase by Guerra, Guadalupe, Petrov, Valery V., Allen, Kenneth E., Miranda, Manuel, Pardo, Juan Pablo, Slayman, Carolyn W.

“…Of the four transmembrane helices (M4, M5, M6, and M8) that pack together to form the ion-binding sites of P 2-type ATPases, M8 has until now received the…”
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Quality control in the yeast secretory pathway: a misfolded PMA1 H+-ATPase reveals two checkpoints by Ferreira, Thierry, Mason, A Brett, Pypaert, Marc, Allen, Kenneth E, Slayman, Carolyn W

“…The yeast plasma-membrane H(+)-ATPase, encoded by PMA1, is delivered to the cell surface via the secretory pathway and has recently emerged as an excellent…”
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Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H +-ATPase by Morsomme, Pierre, Slayman, Carolyn W, Goffeau, André

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Isolation of an ion channel gene from Arabidopsis thaliana using the H5 signature sequence from voltage-dependent K + channels by Ketchum, Karen A., Slayman, Carolyn W.

“…A degenerate oligonucleotide corresponding to the K + channel signature sequence (TMTTVGYGD) was used to isolate the genomic and cDNA forms of a new channel…”
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Use of a Fluorescent Maleimide to Probe Structure-Function Relationships in Stalk Segments 4 and 5 of the Yeast Plasma-Membrane H+-ATPase by SLAYMAN, CAROLYN W., MIRANDA, MANUEL, PARDO, JUAN PABLO, ALLEN, KENNETH E.

“…: In the yeast plasma‐membrane H+‐ATPase and other P‐type ATPases, conformational changes are transmitted between cytoplasmic and membrane‐embedded domains via…”
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Stalk segment 5 of the yeast plasma membrane H(+)-ATPase. Labeling with a fluorescent maleimide reveals a conformational change during glucose activation by Miranda, Manuel, Pardo, Juan Pablo, Allen, Kenneth E, Slayman, Carolyn W

“…Glucose is well known to cause a rapid, reversible activation of the yeast plasma membrane H(+)-ATPase, very likely mediated by phosphorylation of two or more…”
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Stalk Segment 5 of the Yeast Plasma Membrane H+-ATPase by Miranda, Manuel, Pardo, Juan Pablo, Allen, Kenneth E., Slayman, Carolyn W.

“…Glucose is well known to cause a rapid, reversible activation of the yeast plasma membrane H + -ATPase, very likely mediated by phosphorylation of two or more…”
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Substitutions of aspartate 378 in the phosphorylation domain of the yeast PMA1 H+-ATPase disrupt protein folding and biogenesis by Nakamoto, R.K, Verjovski-Almeida, S, Allen, K.E, Ambesi, A, Rao, R, Slayman, C.W

“…There is strong evidence that Asp-378 of the yeast PMA1 ATPase plays an essential role in ATP hydrolysis by forming a covalent β-aspartyl phosphate reaction…”
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Quality Control in the Yeast Secretory Pathway by Ferreira, Thierry, Mason, A. Brett, Pypaert, Marc, Allen, Kenneth E., Slayman, Carolyn W.

“…The yeast plasma-membrane H+-ATPase, encoded by PMA1, is delivered to the cell surface via the secretory pathway and has recently emerged as an excellent…”
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Functional Role of Charged Residues in the Transmembrane Segments of the Yeast Plasma Membrane H+-ATPase by Petrov, Valery V., Padmanabha, Kristine P., Nakamoto, Robert K., Allen, Kenneth E., Slayman, Carolyn W.

“…As defined by hydropathy analysis, the membrane-spanning segments of the yeast plasma membrane H+-ATPase contain seven negatively charged amino acids (Asp and…”
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Alanine-scanning Mutagenesis along Membrane Segment 4 of the Yeast Plasma Membrane H+-ATPase EFFECTS ON STRUCTURE AND FUNCTION by Ambesi, A, Pan, R L, Slayman, C W

“…Membrane segment 4 of P-type cation pumps has been suggested to play a critical role in the coupling of ATP hydrolysis to ion translocation. In this study,…”
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Evidence for a salt bridge between transmembrane segments 5 and 6 of the yeast plasma-membrane H+ -ATPase by Gupta, S.S. (Yale University School of Medicine, New Haven, CT.), DeWitt, N.D, Allen, K.E, Slayman, C.W

“…The plasma-membrane H + -ATPase of Saccharomyces cerevisiae , which belongs to the P 2 subgroup of cation-transporting ATPases, is encoded by the PMA1 gene and…”
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Stalk Segment 4 of the Yeast Plasma Membrane H+-ATPase by Ambesi, Anthony, Miranda, Manuel, Allen, Kenneth E., Slayman, Carolyn W.

“…In the P2-type ATPases, there is growing evidence that four α-helical stalk segments connect the cytoplasmic part of the molecule, responsible for ATP binding…”
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