Search Results - "Slavny, Peter"

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies by Laustsen, Andreas H., Karatt-Vellatt, Aneesh, Masters, Edward W., Arias, Ana Silvia, Pus, Urska, Knudsen, Cecilie, Oscoz, Saioa, Slavny, Peter, Griffiths, Daniel T., Luther, Alice M., Leah, Rachael A., Lindholm, Majken, Lomonte, Bruno, Gutiérrez, José María, McCafferty, John

“…The black mamba ( Dendroaspis polylepis ) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom…”
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Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects by Slavny, Peter, Hegde, Manjunath, Doerner, Achim, Parthiban, Kothai, McCafferty, John, Zielonka, Stefan, Hoet, Rene

“…The evolving development landscape of biotherapeutics and their growing complexity from simple antibodies into bi- and multi-specific molecules necessitates…”
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Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy? by Aungier, Susan R, Cartwright, Alison J, Schwenzer, Anja, Marshall, Jennifer L, Dyson, Michael R, Slavny, Peter, Parthiban, Kothai, Karatt-Vellatt, Aneesh, Sahbudin, Ilfita, Culbert, Eric, Hextall, Patrick, Clanchy, Felix Il, Williams, Richard, Marsden, Brian D, Raza, Karim, Filer, Andrew, Buckley, Christopher Dominic, McCafferty, John, Midwood, Kim S

“…Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. We investigated whether targeting proinflammatory signals…”
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Influence of PAS domain flanking regions on oligomerisation and redox signalling by NifL by Little, Richard, Slavny, Peter, Dixon, Ray

“…Per-ARNT-Sim (PAS) domains constitute a typically dimeric, conserved α/β tertiary fold of approximately 110 amino acids that perform signalling roles in…”
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In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom by Ledsgaard, Line, Laustsen, Andreas H., Pus, Urska, Wade, Jack, Villar, Pedro, Boddum, Kim, Slavny, Peter, Masters, Edward W., Arias, Ana S., Oscoz, Saioa, Griffiths, Daniel T., Luther, Alice M., Lindholm, Majken, Leah, Rachael A., Møller, Marie Sofie, Ali, Hanif, McCafferty, John, Lomonte, Bruno, Gutiérrez, José M., Karatt-Vellatt, Aneesh

“…The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain…”
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Publisher Correction: In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies by Laustsen, Andreas H., Karatt-Vellatt, Aneesh, Masters, Edward W., Arias, Ana Silvia, Pus, Urska, Knudsen, Cecilie, Oscoz, Saioa, Slavny, Peter, Griffiths, Daniel T., Luther, Alice M., Leah, Rachael A., Lindholm, Majken, Lomonte, Bruno, Gutiérrez, José María, McCafferty, John

“…In the original version of this Article, the sixth sentence of the first paragraph of the Introduction incorrectly read ‘Particularly, elapid antivenoms often…”
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Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain by DiCara, Danielle M., Chirgadze, Dimitri Y., Pope, Anthony R., Karatt-Vellatt, Aneesh, Winter, Anja, Slavny, Peter, van den Heuvel, Joop, Parthiban, Kothai, Holland, Jane, Packman, Len C., Mavria, Georgia, Hoffmann, Jens, Birchmeier, Walter, Gherardi, Ermanno, McCafferty, John

“…The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and…”
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Quaternary structure changes in a second Per-Arnt-Sim domain mediate intramolecular redox signal relay in the NifL regulatory protein by Slavny, Peter, Little, Richard, Salinas, Paloma, Clarke, Thomas A, Dixon, Ray

“…Per-Arnt-Sim (PAS) domains play a critical role in signal transduction in multidomain proteins by sensing diverse environmental signals and regulating the…”
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Cocktails of human monoclonal IgG antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba venom in vivo by Laustsen, Andreas H., Karatt-Vellatt, Aneesh, Masters, Edward W., Arias, Ana Silvia, Pus, Urska, Knudsen, Cecilie, Oscoz, Saioa, Slavny, Peter, Griffiths, Daniel T., Luther, Alice M., Leah, Rachael A., Lindholm, Majken, Lomonte, Bruno, Mar a Guti rrez, Jos, McCafferty, John

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Harnessing human monoclonal antibodies for neutralisation of dendrotoxins in a murine model by Knudsen, Cecilie, Arias, Ana Silvia, Lomonte, Bruno, Mar a Guti rrez, Jos, Puš, rška, Oscoz, Saioa, Masters, Edward W., Luther, Alice M., Griffiths, Daniel.T., Olesen, Majken L., Leah, Rachael A, Slavny, Peter, Karatt-Vellatt, Aneesh, McCafferty, John, Laustsen, Andreas H.

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Response to: 'Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis' by Cutolo et al by Aungier, Susan, Cartwright, Alison J, Schwenzer, Anja, Marshall, Jennifer, Dyson, Mike R, Slavny, Peter, Parthiban, Kothai, Karatt-Vellatt, Aneesh, Sahbudin, Ilfita, Culbert, Eric, Hextall, Patrick, Clanchy, Felix Il, Williams, Richard, Marsden, Brian D, Raza, Karim, Filer, Andrew, Buckley, Christopher D, McCafferty, John, Midwood, Kim S

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Harnessing phage display technology for generating fully human IgG antibodies that neutralise elapid neurotoxins by Karatt-Vellatt, Aneesh, Laustsen, Andreas H., Masters, Edward W., Oscoz, Saioa, Pus, Urska, Knudsen, Cecilie, Slavny, Peter, Luther, Alice M., Leah, Rachael A., Grifiths, Daniel T., Olesen, Majken L., Lomonte, Bruno, Gutiérrez, José María, McCafferty, John

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Substitutions in the redox‐sensing PAS domain of the NifL regulatory protein define an inter‐subunit pathway for redox signal transmission by Little, Richard, Salinas, Paloma, Slavny, Peter, Clarke, Thomas A., Dixon, Ray

“…Summary The Per‐ARNT‐Sim (PAS) domain is a conserved α/β fold present within a plethora of signalling proteins from all kingdoms of life. PAS domains are often…”
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The immunoglobulin domain of the sodium channel beta 3 subunit contains a surface-localized disulfide bond that is required for homophilic binding by Yereddi, Nikitha R, Cusdin, Fiona S, Namadurai, Sivakumar, Packman, Len C, Monie, Tom P, Slavny, Peter, Clare, Jeffrey J, Powell, Andrew J, Jackson, Antony P

“…The beta subunits of voltage-gated sodium (Nav) channels possess an extracellular immunoglobulin (Ig) domain that is related to the L1 family of cell-adhesion…”
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The immunoglobulin domain of the sodium channel β3 subunit contains a surface‐localized disulfide bond that is required for homophilic binding by Yereddi, Nikitha R., Cusdin, Fiona S., Namadurai, Sivakumar, Packman, Len C., Monie, Tom P., Slavny, Peter, Clare, Jeffrey J., Powell, Andrew J., Jackson, Antony P.

“…The β subunits of voltage‐gated sodium (Nav) channels possess an extracellular immunoglobulin (Ig) domain that is related to the L1 family of cell‐adhesion…”
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Role of the pas2 domain of the nifl regulatory protein in redox signal transduction by Slavny, Peter

“…Per-Arnt-Sim (PAS) domains play a critical role in signal transduction in multi-domain proteins by sensing diverse environmental signals and regulating the…”
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