Search Results - "Slavikova, Barbora"

C‑3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10 by Hanzlova, Michaela, Slavikova, Barbora, Morozovova, Marina, Musilek, Kamil, Rotterova, Aneta, Zemanová, Lucie, Kudova, Eva

“…17β-HSD10 is a mitochondrial enzyme that catalyzes the steroidal oxidation of a hydroxy group to a keto group and, thus, is involved in maintaining steroid…”
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Correction to “C‑3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10” by Hanzlova, Michaela, Slavikova, Barbora, Morozovova, Marina, Musilek, Kamil, Rotterova, Aneta, Zemanová, Lucie, Kudova, Eva

“…[This corrects the article DOI: 10.1021/acsomega.3c10148.]…”
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Access of inhibitory neurosteroids to the NMDA receptor by Borovska, Jirina, Vyklicky, Vojtech, Stastna, Eva, Kapras, Vojtech, Slavikova, Barbora, Horak, Martin, Chodounska, Hana, Vyklicky Jr, Ladislav

“…BACKGROUND AND PURPOSE NMDA receptors are glutamatergic ionotropic receptors involved in excitatory neurotransmission, synaptic plasticity and excitotoxic cell…”
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Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N -Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif by Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Vyklicky, Vojtech, Ladislav, Marek, Hubalkova, Pavla, Krausova, Barbora, Smejkalova, Tereza, Nekardova, Michaela, Smidkova, Marketa, Monincova, Lenka, Soucek, Radko, Vyklicky, Ladislav, Kudova, Eva

“…Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of -methyl-D-aspartate receptors…”
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Chiral ligand induced geometrical type of isomerism in Schiff-base Copper(II) complexes with urease inhibitory activities by Valentová, Jindra, Lintnerová, Lucia, Sláviková, Barbora, Baran, Peter

“…[Display omitted] •Novel copper(II) complexes with Schiff-base ligands derived from 2-formylphenoxyacetic acid (fphaa) and DL-α-alanine, β-alanine, taurine,…”
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Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties by Kuda, Ondrej, Brezinova, Marie, Rombaldova, Martina, Slavikova, Barbora, Posta, Martin, Beier, Petr, Janovska, Petra, Veleba, Jiri, Kopecky, Jr, Jan, Kudova, Eva, Pelikanova, Terezie, Kopecky, Jan

“…White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with…”
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Synthesis of Fluorinated Brassinosteroids Based on Alkene Cross-Metathesis and Preliminary Biological Assessment by Eignerová, Barbara, Slavíková, Barbora, Buděšínský, Miloš, Dračínský, Martin, Klepetářová, Blanka, Št’astná, Eva, Kotora, Martin

“…Three types of brassinosteroid analogues with perfluoroalkylated side chains were synthesized by using alkene cross-metathesis of a brassinosteroid derivative…”
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Allopregnanolone and Pregnanolone Analogues Modified in the C Ring: Synthesis and Activity by Slavíková, Barbora, Bujons, Jordi, Matyáš, Libor, Vidal, Miguel, Babot, Zoila, Krištofíková, Zdena, Suñol, Cristina, Kasal, Alexander

“…(25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the…”
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Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating by Sivcev, Sonja, Slavikova, Barbora, Rupert, Marian, Ivetic, Milorad, Nekardova, Michaela, Kudova, Eva, Zemkova, Hana

“…P2X receptors (P2XRs) are ATP‐gated cationic channels that are allosterically modulated by numerous compounds, including steroids and neurosteroids. These…”
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Positive Modulators of the N‑Methyl‑d‑aspartate Receptor: Structure–Activity Relationship Study of Steroidal 3‑Hemiesters by Krausova, Barbora, Slavikova, Barbora, Nekardova, Michaela, Hubalkova, Pavla, Vyklicky, Vojtech, Chodounska, Hana, Vyklicky, Ladislav, Kudova, Eva

“…Here, we report the synthesis of pregn-5-ene and androst-5-ene dicarboxylic acid esters and explore the structure–activity relationship (SAR) for their…”
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Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating by Sivcev, Sonja, Slavikova, Barbora, Ivetic, Milorad, Knezu, Michal, Kudova, Eva, Zemkova, Hana

“…•We tested a hypothesis that bile acids modulate activity of the rat P2X receptors.•We designed and synthesized several derivatives of lithocholic…”
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5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia by Munawar Cheema, Marie, Macakova Kotrbova, Zuzana, Hrcka Krausova, Barbora, Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Kratochvil, Miroslav, Vondrasek, Jiri, Sedlak, David, Balastik, Martin, Kudova, Eva

“…Endogenous neurosteroids (NS) and their synthetic analogs, neuroactive steroids (NAS), are potentially useful drug-like compounds affecting the pathophysiology…”
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A New Class of Potent N‑Methyl‑d‑Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D‑Ring Modifications by Kudova, Eva, Chodounska, Hana, Slavikova, Barbora, Budesinsky, Milos, Nekardova, Michaela, Vyklicky, Vojtech, Krausova, Barbora, Svehla, Pavel, Vyklicky, Ladislav

“…N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play a crucial role in excitatory synaptic transmission. However, the…”
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Pregn-5-en-3β-ol and androst-5-en-3β-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability by Matousova, Marika, Soucek, Radko, Tloustova, Eva, Slavikova, Barbora, Chodounska, Hana, Mertlikova-Kaiserova, Helena, Kudova, Eva

“…[Display omitted] •In vitro safety evaluation of positive modulators of NMDA receptor.•NMDA receptor positive allosteric modulation as a potential therapeutic…”
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Screening of novel 3α5β-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity by Smidkova, Marketa, Hajek, Miroslav, Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Matousova, Marika, Mertlikova-Kaiserova, Helena, Kudova, Eva

“…[Display omitted] •3α5β-Neurosteroids suppress both glutamate- and NMDA-induced excitotoxicity.•Ca2+ entry and consequent ROS release and caspase-3 activation…”
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Neurosteroid-like Inhibitors of N‑Methyl‑d‑aspartate Receptor: Substituted 2‑Sulfates and 2‑Hemisuccinates of Perhydrophenanthrene by Slavikova, Barbora, Chodounska, Hana, Nekardova, Michaela, Vyklicky, Vojtech, Ladislav, Marek, Hubalkova, Pavla, Krausova, Barbora, Vyklicky, Ladislav, Kudova, Eva

“…N-Methyl-d-aspartate receptors (NMDARs) display a critical role in various diseases of the central nervous system. The activity of NMDARs can be modulated by…”
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Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors by Adla, Santosh Kumar, Slavikova, Barbora, Smidkova, Marketa, Tloustova, Eva, Svoboda, Martin, Vyklicky, Vojtech, Krausova, Barbora, Hubalkova, Pavla, Nekardova, Michaela, Holubova, Kristina, Vales, Karel, Budesinsky, Milos, Vyklicky, Ladislav, Chodounska, Hana, Kudova, Eva

“…[Display omitted] •Synthesis of new amide-based inhibitors of NMDA receptors.•Strong inhibitors of NMDA currents.•The Caco-2 assay was used to evaluate…”
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Allopregnanolone (3α-Hydroxy-5α-pregnan-20-one) Derivatives with a Polar Chain in Position 16α: Synthesis and Activity by Slavíková, Barbora, Krištofíková, Zdena, Chodounská, Hana, Buděšínský, Miloš, Durán, Fernando J, Veleiro, Adriana S, Burton, Gerardo, Kasal, Alexander

“…The lipophilic nature of allopregnanolone prevents its user-friendly application in human medicine. On inspiration by previously prepared allopregnanolone with…”
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Erratum. Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. Diabetes 2016;65:2580-2590 by Kuda, Ondrej, Brezinova, Marie, Rombaldova, Martina, Slavikova, Barbora, Posta, Martin, Beier, Petr, Janovska, Petra, Veleba, Jiri, Kopecky, Jr, Jan, Kudova, Eva, Pelikanova, Terezie, Kopecky, Jan

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Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues by Slavikova, Barbora, Kohout, Ladislav, Budesinsky, Milos, Swaczynova, Jana, Kasal, Alexander

“…Three types of 5α-androstane and ergostane analogues of brassinolide, containing a fluorine atom in either the 3α or the 5α positions or in 3α and 5α…”
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